Q9BUQ8: Probable ATP-dependent RNA helicase DDX23

General Information

Protein names	- Probable ATP-dependent RNA helicase DDX23 - 3.6.4.13 - 100 kDa U5 snRNP-specific protein - DEAD box protein 23 - PRP28 homolog - U5-100kD
Gene names	DDX23
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BUQ8

10 N-termini

7 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGELADKKD RDASPSKEER KRSRTPDRER DRDRDRKSSP SKDRKRHRSR DRRRGGSRSR
        70         80         90        100        110        120
SRSRSKSAER ERRHKERERD KERDRNKKDR DRDKDGHRRD KDRKRSSLSP GRGKDFKSRK
       130        140        150        160        170        180
DRDSKKDEED EHGDKKPKAQ PLSLEELLAK KKAEEEAEAK PKFLSKAERE AEALKRRQQE
       190        200        210        220        230        240
VEERQRMLEE ERKKRKQFQD LGRKMLEDPQ ERERRERRER MERETNGNED EEGRQKIREE
       250        260        270        280        290        300
KDKSKELHAI KERYLGGIKK RRRTRHLNDR KFVFEWDASE DTSIDYNPLY KERHQVQLLG
       310        320        330        340        350        360
RGFIAGIDLK QQKREQSRFY GDLMEKRRTL EEKEQEEARL RKLRKKEAKQ RWDDRHWSQK
       370        380        390        400        410        420
KLDEMTDRDW RIFREDYSIT TKGGKIPNPI RSWKDSSLPP HILEVIDKCG YKEPTPIQRQ
       430        440        450        460        470        480
AIPIGLQNRD IIGVAETGSG KTAAFLIPLL VWITTLPKID RIEESDQGPY AIILAPTREL
       490        500        510        520        530        540
AQQIEEETIK FGKPLGIRTV AVIGGISRED QGFRLRMGCE IVIATPGRLI DVLENRYLVL
       550        560        570        580        590        600
SRCTYVVLDE ADRMIDMGFE PDVQKILEHM PVSNQKPDTD EAEDPEKMLA NFESGKHKYR
       610        620        630        640        650        660
QTVMFTATMP PAVERLARSY LRRPAVVYIG SAGKPHERVE QKVFLMSESE KRKKLLAILE
       670        680        690        700        710        720
QGFDPPIIIF VNQKKGCDVL AKSLEKMGYN ACTLHGGKGQ EQREFALSNL KAGAKDILVA
       730        740        750        760        770        780
TDVAGRGIDI QDVSMVVNYD MAKNIEDYIH RIGRTGRAGK SGVAITFLTK EDSAVFYELK
       790        800        810        820
QAILESPVSS CPPELANHPD AQHKPGTILT KKRREETIFA

Isoforms

- Isoform 2 of Probable ATP-dependent RNA helicase DDX23

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

10 N-termini - 7 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BUQ8-1-unknown	MAGELA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BUQ8-2-unknown	AGELAD...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9BUQ8-2-unknown	AGELAD...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9BUQ8-2-	AGELAD...	2		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9BUQ8-143-unknown	SLEELL...	143	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14959
Q9BUQ8-149-unknown	AKKKAE...	149	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14960
Q9BUQ8-157-unknown	AEAKPK...	157	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449657
Q9BUQ8-282-unknown	TSIDYN...	282	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13216
Q9BUQ8-574-unknown	NQKPDT...	574	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6741
Q9BUQ8-732-	DVSMVV...	732		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9BUQ8-732-unknown	DVSMVV...	732		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DKKPKA	138	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446948
...KAQPLS	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14959
...LEELLA	148	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14960
...QQEVEE	182	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449639
...DASEDT	281	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13216
...HMPVSN	573	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6741
...ETIFA	820	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	142	QPLS.\|.SLEE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	148	ELLA.\|.AKKK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	281	SEDT.\|.TSID	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	573	PVSN.\|.NQKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)