P68104: Elongation factor 1-alpha 1

General Information

Protein names	- Elongation factor 1-alpha 1 - EF-1-alpha-1 - Elongation factor Tu - EF-Tu - Eukaryotic elongation factor 1 A-1 - eEF1A-1 - Leukocyte receptor cluster member 7
Gene names	EEF1A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P68104

41 N-termini

15 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG KGSFKYAWVL
        70         80         90        100        110        120
DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK NMITGTSQAD CAVLIVAAGV
       130        140        150        160        170        180
GEFEAGISKN GQTREHALLA YTLGVKQLIV GVNKMDSTEP PYSQKRYEEI VKEVSTYIKK
       190        200        210        220        230        240
IGYNPDTVAF VPISGWNGDN MLEPSANMPW FKGWKVTRKD GNASGTTLLE ALDCILPPTR
       250        260        270        280        290        300
PTDKPLRLPL QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS
       310        320        330        340        350        360
EALPGDNVGF NVKNVSVKDV RRGNVAGDSK NDPPMEAAGF TAQVIILNHP GQISAGYAPV
       370        380        390        400        410        420
LDCHTAHIAC KFAELKEKID RRSGKKLEDG PKFLKSGDAA IVDMVPGKPM CVESFSDYPP
       430        440        450        460
LGRFAVRDMR QTVAVGVIKA VDKKAAGAGK VTKSAQKAQK AK

Isoforms

- Isoform 2 of Elongation factor 1-alpha 1

Sequence View

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Protein Neighborhood

Domains & Features

41 N-termini - 15 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P68104-1-unknown	MGKEKT...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P68104-7-unknown	HINIVV...	7	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P68104-15-	HVDSGK...	15		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P68104-21-	STTTGH...	21		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P68104-21-	STTTGH...	21		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P68104-38-	TIEKFE...	38		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P68104-42-	FEKEAA...	42		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P68104-42-	FEKEAA...	42		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P68104-119-unknown	GVGEFE...	119	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P68104-119-	GVGEFE...	119		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P68104-131-	GQTREH...	131		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68104-198-	GDNMLE...	198		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P68104-198-	GDNMLE...	198		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68104-198-	GDNMLE...	198		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P68104-200-	NMLEPS...	200		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P68104-201-	MLEPSA...	201		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P68104-201-	MLEPSA...	201		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68104-201-	MLEPSA...	201		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P68104-201-	MLEPSA...	201		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P68104-201-	MLEPSA...	201		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P68104-201-	MLEPSA...	201		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P68104-226-unknown	TTLLEA...	226	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17809
P68104-230-unknown	EALDCI...	230	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17810
P68104-248-	LPLQDV...	248		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P68104-248-	LPLQDV...	248		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P68104-248-	LPLQDV...	248		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P68104-253-unknown	VYKIGG...	253	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11802
P68104-254-unknown	YKIGGI...	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15347
P68104-256-	IGGIGT...	256		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P68104-258-	GIGTVP...	258		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P68104-258-	GIGTVP...	258		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P68104-258-	GIGTVP...	258		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P68104-261-	TVPVGR...	261		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P68104-267-	VETGVL...	267		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P68104-267-	VETGVL...	267		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P68104-267-	VETGVL...	267		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P68104-267-	VETGVL...	267		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P68104-271-	VLKPGM...	271		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P68104-276-	MVVTFA...	276		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P68104-276-	MVVTFA...	276		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68104-276-	MVVTFA...	276		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P68104-276-	MVVTFA...	276		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P68104-279-	TFAPVN...	279		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P68104-279-	TFAPVN...	279		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P68104-280-	FAPVNV...	280		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68104-280-	FAPVNV...	280		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P68104-280-	FAPVNV...	280		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P68104-280-	FAPVNV...	280		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P68104-280-	FAPVNV...	280		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P68104-280-	FAPVNV...	280		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P68104-302-	ALPGDN...	302		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P68104-302-	ALPGDN...	302		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P68104-302-	ALPGDN...	302		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P68104-302-	ALPGDN...	302		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68104-302-	ALPGDN...	302		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P68104-302-	ALPGDN...	302		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P68104-302-	ALPGDN...	302		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P68104-302-	ALPGDN...	302		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P68104-337-unknown	AAGFTA...	337	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14294
P68104-355-unknown	AGYAPV...	355	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6157
P68104-363-unknown	CHTAHI...	363	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1259
P68104-371-unknown	KFAELK...	371	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14295
P68104-396-	SGDAAI...	396		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P68104-399-unknown	AAIVDM...	399	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11803
P68104-404-unknown	MVPGKP...	404	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1260
P68104-404-	MVPGKP...	404		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P68104-404-	MVPGKP...	404		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P68104-411-unknown	CVESFS...	411	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14296
P68104-414-unknown	SFSDYP...	414	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11804
P68104-414-	SFSDYP...	414		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68104-414-	SFSDYP...	414		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P68104-414-	SFSDYP...	414		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P68104-416-unknown	SDYPPL...	416		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P68104-416-	SDYPPL...	416		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P68104-445-unknown	AAGAGK...	445		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P68104-445-	AAGAGK...	445		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P68104-445-	AAGAGK...	445		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MITGTS	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392366
...YTLGVK	145	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000348651
...GNASGT	225	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17809
...GTTLLE	229	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17810
...LPLQDV	252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11802
...PLQDVY	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15347
...DPPMEA	336	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14294
...PGQISA	354	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6157
...APVLDC	362	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1259
...AHIACK	370	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14295
...LKSGDA	398	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11803
...AAIVDM	403	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1260
...PGKPMC	410	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14296
...PMCVES	413	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11804
...AQKAK	462	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	225	ASGT.\|.TTLL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	229	TLLE.\|.EALD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	252	LQDV.\|.VYKI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	253	QDVY.\|.YKIG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	336	PMEA.\|.AAGF	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	354	QISA.\|.AGYA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP1_HUMAN	362	VLDC.\|.CHTA	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
GRAM_HUMAN	370	IACK.\|.KFAE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	398	SGDA.\|.AAIV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP1_HUMAN	403	IVDM.\|.MVPG	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
GRAM_HUMAN	410	KPMC.\|.CVES	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	413	CVES.\|.SFSD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)