Q8IYS1: Peptidase M20 domain-containing protein 2

General Information

Protein names	- Peptidase M20 domain-containing protein 2 - Aminoacylase-1-like protein 2
Gene names	PM20D2
Organism	Homo sapiens
Protease Family
Protease ID	M20.971
Chromosome location
UniProt ID	Q8IYS1

4 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRPGGERPVE GGACNGRSEL ELLKLRSAEC IDEAAERLGA LSRAIWSQPE LAYEEHHAHR
        70         80         90        100        110        120
VLTHFFEREP PAASWAVQPH YQLPTAFRAE WEPPEARAPS ATPRPLHLGF LCEYDALPGI
       130        140        150        160        170        180
GHACGHNLIA EVGAAAALGV RGALEGLPRP PPPVKVVVLG TPAEEDGGGK IDLIEAGAFT
       190        200        210        220        230        240
NLDVVFMAHP SQENAAYLPD MAEHDVTVKY YGKASHSASY PWEGLNALDA AVLAYNNLSV
       250        260        270        280        290        300
FRQQMKPTWR VHGIIKNGGV KPNIIPSYSE LIYYFRAPSM KELQVLTKKA EDCFRAAALA
       310        320        330        340        350        360
SGCTVEIKGG AHDYYNVLPN KSLWKAYMEN GRKLGIEFIS EDTMLNGPSG STDFGNVSFV
       370        380        390        400        410        420
VPGIHPYFHI GSNALNHTEQ YTEAAGSQEA QFYTLRTAKA LAMTALDVIF KPELLEGIRE
       430
DFKLKLQEEQ FVNAVE

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IYS1-1-	MRPGGE...	1		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q8IYS1-1-	MRPGGE...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8IYS1-1-unknown	MRPGGE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IYS1-1-unknown	MRPGGE...	1		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8IYS1-4-	GGERPV...	4		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q8IYS1-4-	GGERPV...	4		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q8IYS1-4-	GGERPV...	4		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8IYS1-4-	GGERPV...	4		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8IYS1-146-unknown	GLPRPP...	146	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7946
Q8IYS1-146-unknown	GLPRPP...	146	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6581

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RGALEG	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7946
...RGALEG	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6581
...VNAVE	436	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	145	ALEG.\|.GLPR	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	145	ALEG.\|.GLPR	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)