O14579: Coatomer subunit epsilon

General Information

Protein names	- Coatomer subunit epsilon - Epsilon-coat protein - Epsilon-COP
Gene names	COPE
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14579

10 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Coatomer subunit epsilon - Isoform 3 of Coatomer subunit epsilon

Sequence View

        10         20         30         40         50         60
MAPPAPGPAS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPERDV ERDVFLYRAY
        70         80         90        100        110        120
LAQRKFGVVL DEIKPSSAPE LQAVRMFADY LAHESRRDSI VAELDREMSR SVDVTNTTFL
       130        140        150        160        170        180
LMAASIYLHD QNPDAALRAL HQGDSLECTA MTVQILLKLD RLDLARKELK RMQDLDEDAT
       190        200        210        220        230        240
LTQLATAWVS LATGGEKLQD AYYIFQEMAD KCSPTLLLLN GQAACHMAQG RWEAAEGLLQ
       250        260        270        280        290        300
EALDKDSGYP ETLVNLIVLS QHLGKPPEVT NRYLSQLKDA HRSHPFIKEY QAKENDFDRL

VLQYAPSA         10         20         30         40         50         60
MAPPAPGPAS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPERDV ERDVFLYRAY
        70         80         90        100        110        120
LAQRKFGVVL DEIKPSSAPE LQAVRMFADY LAHESRRDSI VAELDREMSR SVDVTNTTFL
       130        140        150        160        170        180
LMAASIYLHD QNPDAALRAL HQGDSLECTA MTVQILLKLD RLDLARKELK RMQDLDEDAT
       190        200        210        220        230        240
LTQLATAWVS LATGGEKLQD AYYIFQEMAD KCSPTLLLLN GQAACHMAQG RWEAAEGLLQ
       250        260        270        280        290        300
EALDKDSGYP ETLVNLIVLS QHLGKPPEVT NRYLSQLKDA HRSHPFIKEY QAKENDFDRL

VLQYAPSA

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14579-1-unknown	MAPPAP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71424
O14579-1-unknown	MAPPAP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71423
O14579-2-	APPAPG...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14579-2-	APPAPG...	2		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O14579-2-unknown	APPAPG...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14579-2-unknown	APPAPG...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111469
O14579-2-unknown	APPAPG...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111470
O14579-5-unknown	APGPAS...	5	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170924
O14579-5-unknown	APGPAS...	5	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170925
O14579-5-	APGPAS...	5		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14579-5-	APGPAS...	5		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O14579-7-	GPASGG...	7		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O14579-7-unknown	GPASGG...	7	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174921
O14579-7-unknown	GPASGG...	7	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174922
O14579-9-unknown	ASGGSG...	9	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170928
O14579-9-unknown	ASGGSG...	9	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170929
O14579-9-	ASGGSG...	9		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14579-9-	ASGGSG...	9		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O14579-129-unknown	HDQNPD...	129	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5107
O14579-129-unknown	HDQNPD...	129	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143876

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...ASIYLH	128	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5107
...ASIYLH	128	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127120
...YAPSA	308		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...YAPSA	308		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...YAPSA	308	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...YAPSA	308	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt67042
...YAPSA	308	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt67041
...YAPSA	308		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...YAPSA	308		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	128	IYLH.\|.HDQN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)