Q14566: DNA replication licensing factor MCM6

General Information

Protein names	- DNA replication licensing factor MCM6 - 3.6.4.12 - p105MCM
Gene names	MCM6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14566

18 N-termini

5 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDLAAAAEPG AGSQHLEVRD EVAEKCQKLF LDFLEEFQSS DGEIKYLQLA EELIRPERNT
        70         80         90        100        110        120
LVVSFVDLEQ FNQQLSTTIQ EEFYRVYPYL CRALKTFVKD RKEIPLAKDF YVAFQDLPTR
       130        140        150        160        170        180
HKIRELTSSR IGLLTRISGQ VVRTHPVHPE LVSGTFLCLD CQTVIRDVEQ QFKYTQPNIC
       190        200        210        220        230        240
RNPVCANRRR FLLDTNKSRF VDFQKVRIQE TQAELPRGSI PRSLEVILRA EAVESAQAGD
       250        260        270        280        290        300
KCDFTGTLIV VPDVSKLSTP GARAETNSRV SGVDGYETEG IRGLRALGVR DLSYRLVFLA
       310        320        330        340        350        360
CCVAPTNPRF GGKELRDEEQ TAESIKNQMT VKEWEKVFEM SQDKNLYHNL CTSLFPTIHG
       370        380        390        400        410        420
NDEVKRGVLL MLFGGVPKTT GEGTSLRGDI NVCIVGDPST AKSQFLKHVE EFSPRAVYTS
       430        440        450        460        470        480
GKASSAAGLT AAVVRDEESH EFVIEAGALM LADNGVCCID EFDKMDVRDQ VAIHEAMEQQ
       490        500        510        520        530        540
TISITKAGVK ATLNARTSIL AAANPISGHY DRSKSLKQNI NLSAPIMSRF DLFFILVDEC
       550        560        570        580        590        600
NEVTDYAIAR RIVDLHSRIE ESIDRVYSLD DIRRYLLFAR QFKPKISKES EDFIVEQYKH
       610        620        630        640        650        660
LRQRDGSGVT KSSWRITVRQ LESMIRLSEA MARMHCCDEV QPKHVKEAFR LLNKSIIRVE
       670        680        690        700        710        720
TPDVNLDQEE EIQMEVDEGA GGINGHADSP APVNGINGYN EDINQESAPK ASLRLGFSEY
       730        740        750        760        770        780
CRISNLIVLH LRKVEEEEDE SALKRSELVN WYLKEIESEI DSEEELINKK RIIEKVIHRL
       790        800        810        820
THYDHVLIEL TQAGLKGSTE GSESYEEDPY LVVNPNYLLE D

Isoforms

Sequence View

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Directness:

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

18 N-termini - 5 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14566-1-Acetylation	MDLAAA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14566-1-Acetylation	MDLAAA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q14566-1-Acetylation	MDLAAA...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q14566-1-Acetylation	MDLAAA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q14566-4-	AAAAEP...	4			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14566-4-	AAAAEP...	4			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14566-5-	AAAEPG...	5			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14566-5-	AAAEPG...	5			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14566-5-	AAAEPG...	5			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14566-5-	AAAEPG...	5			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14566-5-unknown	AAAEPG...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7833
Q14566-5-unknown	AAAEPG...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6397
Q14566-254-unknown	VSKLST...	254		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12242
Q14566-275-unknown	GYETEG...	275			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q14566-275-	GYETEG...	275			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q14566-275-	GYETEG...	275			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14566-275-	GYETEG...	275			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q14566-275-	GYETEG...	275			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14566-275-	GYETEG...	275			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14566-275-	GYETEG...	275			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14566-275-	GYETEG...	275			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q14566-275-	GYETEG...	275			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
Q14566-275-	GYETEG...	275			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14566-408-	HVEEFS...	408			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14566-416-	AVYTSG...	416			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14566-416-	AVYTSG...	416			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14566-454-unknown	NGVCCI...	454		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12243
Q14566-454-	NGVCCI...	454			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14566-454-	NGVCCI...	454			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q14566-454-	NGVCCI...	454			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14566-502-unknown	AANPIS...	502		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6398
Q14566-502-	AANPIS...	502			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14566-503-unknown	ANPISG...	503		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4052
Q14566-685-	GHADSP...	685			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14566-685-	GHADSP...	685			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14566-695-	GINGYN...	695			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14566-695-	GINGYN...	695			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14566-695-	GINGYN...	695			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14566-698-	GYNEDI...	698			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14566-698-	GYNEDI...	698			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_CD95	23264352
Q14566-698-	GYNEDI...	698			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q14566-698-	GYNEDI...	698			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q14566-698-	GYNEDI...	698			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14566-698-	GYNEDI...	698			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14566-698-	GYNEDI...	698			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14566-698-	GYNEDI...	698			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14566-698-	GYNEDI...	698			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14566-698-unknown	GYNEDI...	698			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q14566-698-unknown	GYNEDI...	698			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IVVPDV	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12242
...LMLADN	453	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12243
...TSILAA	501	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6398
...SILAAA	502	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4052
...YLLED	821	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	4	DLAA.\|.AAAE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	4	DLAA.\|.AAAE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	253	VPDV.\|.VSKL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	453	LADN.\|.NGVC	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	501	ILAA.\|.AANP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	502	LAAA.\|.ANPI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)