P62826: GTP-binding nuclear protein Ran

General Information

Protein names	- GTP-binding nuclear protein Ran - Androgen receptor-associated protein 24 {ECO:0000303\|PubMed:10400640} - GTPase Ran - Ras-like protein TC4 {ECO:0000303\|PubMed:2108320, ECO:0000303\|PubMed:8276887, ECO:0000303\|PubMed:8421051} - Ras-related nuclear protein
Gene names	RAN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62826

9 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL VFHTNRGPIK
        70         80         90        100        110        120
FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN VPNWHRDLVR VCENIPIVLC
       130        140        150        160        170        180
GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS AKSNYNFEKP FLWLARKLIG DPNLEFVAMP
       190        200        210
ALAPPEVVMD PALAAQYEHD LEVAQTTALP DEDDDL

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P62826-2-unknown	MAAQGE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62826-2-Acetylation	AAQGEP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62826-2-Acetylation	AAQGEP...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P62826-2-Acetylation	AAQGEP...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62826-5-unknown	GEPQVQ...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7646
P62826-42-unknown	TLGVEV...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3888
P62826-43-unknown	LGVEVH...	43		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3889
P62826-47-unknown	VHPLVF...	47		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7647
P62826-47-unknown	VHPLVF...	47		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6126
P62826-89-unknown	MFDVTS...	89		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000441210
P62826-89-unknown	MFDVTS...	89		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000254675
P62826-183-	APPEVV...	183			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62826-187-acetylation	VVMDPA...	187	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KKYVAT	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3888
...KYVATL	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3889
...TLGVEV	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7647
...TLGVEV	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6126
...EHDLEV	202	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444042
...EDDDL	216	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	4	AAQG.\|.GEPQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	41	YVAT.\|.TLGV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	42	VATL.\|.LGVE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	46	GVEV.\|.VHPL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	46	GVEV.\|.VHPL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)