O60551: Glycylpeptide N-tetradecanoyltransferase 2

General Information

Protein names	- Glycylpeptide N-tetradecanoyltransferase 2 - 2.3.1.97 {ECO:0000269\|PubMed:25255805, ECO:0000269\|PubMed:9506952} - Myristoyl-CoA:protein N-myristoyltransferase 2 - NMT 2 - Peptide N-myristoyltransferase 2 - Type II N-myristoyltransferase
Gene names	NMT2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60551

5 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GYLGAKKKKK KQKRKKEKPN
        70         80         90        100        110        120
SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL LSACQGPARN IDEAAKHRYQ
       130        140        150        160        170        180
FWDTQPVPKL DEVITSHGAI EPDKDNVRQE PYSLPQGFMW DTLDLSDAEV LKELYTLLNE
       190        200        210        220        230        240
NYVEDDDNMF RFDYSPEFLL WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS
       250        260        270        280        290        300
VKKMVEINFL CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH
       310        320        330        340        350        360
RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS VRELINTYLK
       370        380        390        400        410        420
QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL SFYTLPSTVM HHPAHKSLKA
       430        440        450        460        470        480
AYSFYNIHTE TPLLDLMSDA LILAKSKGFD VFNALDLMEN KTFLEKLKFG IGDGNLQYYL
       490
YNWRCPGTDS EKVGLVLQ

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60551-1-unknown	MAEDSE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60551-68-	SASDSQ...	68		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O60551-121-unknown	FWDTQP...	121	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3287
O60551-136-unknown	SHGAIE...	136	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5201
O60551-136-unknown	SHGAIE...	136	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7043
O60551-189-unknown	MFRFDY...	189	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000438945

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KHRYQF	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3287
...DEVITS	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5201
...DEVITS	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7043
...GLVLQ	498	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	120	RYQF.\|.FWDT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	135	VITS.\|.SHGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	135	VITS.\|.SHGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)