Q15185: Prostaglandin E synthase 3

General Information

Protein names	- Prostaglandin E synthase 3 - 5.3.99.3 {ECO:0000269\|PubMed:10922363} - Cytosolic prostaglandin E2 synthase - cPGES - Hsp90 co-chaperone - Progesterone receptor complex p23 - Telomerase-binding protein p23
Gene names	PTGES3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15185

11 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Prostaglandin E synthase 3 - Isoform 3 of Prostaglandin E synthase 3 - Isoform 4 of Prostaglandin E synthase 3

Sequence View

        10         20         30         40         50         60
MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID
        70         80         90        100        110        120
PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF
       130        140        150        160
DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE         10         20         30         40         50         60
MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID
        70         80         90        100        110        120
PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF
       130        140        150        160
DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE         10         20         30         40         50         60
MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID
        70         80         90        100        110        120
PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF
       130        140        150        160
DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15185-1-acetylation	MQPASA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q15185-1-acetylation	MQPASA...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q15185-1-	MQPASA...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15185-1-	MQPASA...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15185-1-	MQPASA...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15185-1-	MQPASA...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q15185-1-	MQPASA...	1			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15185-1-unknown	MQPASA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15185-1-unknown	MQPASA...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15185-40-unknown	CLGGSD...	40		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4069
Q15185-41-unknown	LGGSDN...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4070
Q15185-94-	AKLNWL...	94			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q15185-94-	AKLNWL...	94			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q15185-100-unknown	SVDFNN...	100		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6448
Q15185-103-unknown	FNNWKD...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12352
Q15185-105-	NWKDWE...	105			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q15185-134-unknown	EDVDLP...	134		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12353
Q15185-143-unknown	GADDDS...	143		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12354

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KLTFSC	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4069
...LTFSCL	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4070
...KLNWLS	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6448
...WLSVDF	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12352
...NMGGDE	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12353
...LPEVDG	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12354
...MPDLE	160	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	39	TFSC.\|.CLGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	40	FSCL.\|.LGGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	99	NWLS.\|.SVDF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	102	SVDF.\|.FNNW	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	133	GGDE.\|.EDVD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	142	EVDG.\|.GADD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)