Q6P2E9: Enhancer of mRNA-decapping protein 4
Protein names | - Enhancer of mRNA-decapping protein 4 - Autoantigen Ge-1 - Autoantigen RCD-8 - Human enhancer of decapping large subunit - Hedls |
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Gene names | EDC4 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q6P2E9 |
29
N-termini
8
C-termini
8
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MASCASIDIE DATQHLRDIL KLDRPAGGPS AESPRPSSAY NGDLNGLLVP DPLCSGDSTS
70 80 90 100 110 120
ANKTGLRTMP PINLQEKQVI CLSGDDSSTC IGILAKEVEI VASSDSSISS KARGSNKVKI
130 140 150 160 170 180
QPVAKYDWEQ KYYYGNLIAV SNSFLAYAIR AANNGSAMVR VISVSTSERT LLKGFTGSVA
190 200 210 220 230 240
DLAFAHLNSP QLACLDEAGN LFVWRLALVN GKIQEEILVH IRQPEGTPLN HFRRIIWCPF
250 260 270 280 290 300
IPEESEDCCE ESSPTVALLH EDRAEVWDLD MLRSSHSTWP VDVSQIKQGF IVVKGHSTCL
310 320 330 340 350 360
SEGALSPDGT VLATASHDGY VKFWQIYIEG QDEPRCLHEW KPHDGRPLSC LLFCDNHKKQ
370 380 390 400 410 420
DPDVPFWRFL ITGADQNREL KMWCTVSWTC LQTIRFSPDI FSSVSVPPSL KVCLDLSAEY
430 440 450 460 470 480
LILSDVQRKV LYVMELLQNQ EEGHACFSSI SEFLLTHPVL SFGIQVVSRC RLRHTEVLPA
490 500 510 520 530 540
EEENDSLGAD GTHGAGAMES AAGVLIKLFC VHTKALQDVQ IRFQPQLNPD VVAPLPTHTA
550 560 570 580 590 600
HEDFTFGESR PELGSEGLGS AAHGSQPDLR RIVELPAPAD FLSLSSETKP KLMTPDAFMT
610 620 630 640 650 660
PSASLQQITA SPSSSSSGSS SSSSSSSSSL TAVSAMSSTS AVDPSLTRPP EELTLSPKLQ
670 680 690 700 710 720
LDGSLTMSSS GSLQASPRGL LPGLLPAPAD KLTPKGPGQV PTATSALSLE LQEVEPLGLP
730 740 750 760 770 780
QASPSRTRSP DVISSASTAL SQDIPEIASE ALSRGFGSSA PEGLEPDSMA SAASALHLLS
790 800 810 820 830 840
PRPRPGPELG PQLGLDGGPG DGDRHNTPSL LEAALTQEAS TPDSQVWPTA PDITRETCST
850 860 870 880 890 900
LAESPRNGLQ EKHKSLAFHR PPYHLLQQRD SQDASAEQSD HDDEVASLAS ASGGFGTKVP
910 920 930 940 950 960
APRLPAKDWK TKGSPRTSPK LKRKSKKDDG DAAMGSRLTE HQVAEPPEDW PALIWQQQRE
970 980 990 1000 1010 1020
LAELRHSQEE LLQRLCTQLE GLQSTVTGHV ERALETRHEQ EQRRLERALA EGQQRGGQLQ
1030 1040 1050 1060 1070 1080
EQLTQQLSQA LSSAVAGRLE RSIRDEIKKT VPPCVSRSLE PMAGQLSNSV ATKLTAVEGS
1090 1100 1110 1120 1130 1140
MKENISKLLK SKNLTDAIAR AAADTLQGPM QAAYREAFQS VVLPAFEKSC QAMFQQINDS
1150 1160 1170 1180 1190 1200
FRLGTQEYLQ QLESHMKSRK AREQEAREPV LAQLRGLVST LQSATEQMAA TVAGSVRAEV
1210 1220 1230 1240 1250 1260
QHQLHVAVGS LQESILAQVQ RIVKGEVSVA LKEQQAAVTS SIMQAMRSAA GTPVPSAHLD
1270 1280 1290 1300 1310 1320
CQAQQAHILQ LLQQGHLNQA FQQALTAADL NLVLYVCETV DPAQVFGQPP CPLSQPVLLS
1330 1340 1350 1360 1370 1380
LIQQLASDLG TRTDLKLSYL EEAVMHLDHS DPITRDHMGS VMAQVRQKLF QFLQAEPHNS
1390 1400
LGKAARRLSL MLHGLVTPSL P
Isoforms
- Isoform 2 of Enhancer of mRNA-decapping protein 4Sequence View
10 20 30 40 50 60
MASCASIDIE DATQHLRDIL KLDRPAGGPS AESPRPSSAY NGDLNGLLVP DPLCSGDSTS
70 80 90 100 110 120
ANKTGLRTMP PINLQEKQVI CLSGDDSSTC IGILAKEVEI VASSDSSISS KARGSNKVKI
130 140 150 160 170 180
QPVAKYDWEQ KYYYGNLIAV SNSFLAYAIR AANNGSAMVR VISVSTSERT LLKGFTGSVA
190 200 210 220 230 240
DLAFAHLNSP QLACLDEAGN LFVWRLALVN GKIQEEILVH IRQPEGTPLN HFRRIIWCPF
250 260 270 280 290 300
IPEESEDCCE ESSPTVALLH EDRAEVWDLD MLRSSHSTWP VDVSQIKQGF IVVKGHSTCL
310 320 330 340 350 360
SEGALSPDGT VLATASHDGY VKFWQIYIEG QDEPRCLHEW KPHDGRPLSC LLFCDNHKKQ
370 380 390 400 410 420
DPDVPFWRFL ITGADQNREL KMWCTVSWTC LQTIRFSPDI FSSVSVPPSL KVCLDLSAEY
430 440 450 460 470 480
LILSDVQRKV LYVMELLQNQ EEGHACFSSI SEFLLTHPVL SFGIQVVSRC RLRHTEVLPA
490 500 510 520 530 540
EEENDSLGAD GTHGAGAMES AAGVLIKLFC VHTKALQDVQ IRFQPQLNPD VVAPLPTHTA
550 560 570 580 590 600
HEDFTFGESR PELGSEGLGS AAHGSQPDLR RIVELPAPAD FLSLSSETKP KLMTPDAFMT
610 620 630 640 650 660
PSASLQQITA SPSSSSSGSS SSSSSSSSSL TAVSAMSSTS AVDPSLTRPP EELTLSPKLQ
670 680 690 700 710 720
LDGSLTMSSS GSLQASPRGL LPGLLPAPAD KLTPKGPGQV PTATSALSLE LQEVEPLGLP
730 740 750 760 770 780
QASPSRTRSP DVISSASTAL SQDIPEIASE ALSRGFGSSA PEGLEPDSMA SAASALHLLS
790 800 810 820 830 840
PRPRPGPELG PQLGLDGGPG DGDRHNTPSL LEAALTQEAS TPDSQVWPTA PDITRETCST
850 860 870 880 890 900
LAESPRNGLQ EKHKSLAFHR PPYHLLQQRD SQDASAEQSD HDDEVASLAS ASGGFGTKVP
910 920 930 940 950 960
APRLPAKDWK TKGSPRTSPK LKRKSKKDDG DAAMGSRLTE HQVAEPPEDW PALIWQQQRE
970 980 990 1000 1010 1020
LAELRHSQEE LLQRLCTQLE GLQSTVTGHV ERALETRHEQ EQRRLERALA EGQQRGGQLQ
1030 1040 1050 1060 1070 1080
EQLTQQLSQA LSSAVAGRLE RSIRDEIKKT VPPCVSRSLE PMAGQLSNSV ATKLTAVEGS
1090 1100 1110 1120 1130 1140
MKENISKLLK SKNLTDAIAR AAADTLQGPM QAAYREAFQS VVLPAFEKSC QAMFQQINDS
1150 1160 1170 1180 1190 1200
FRLGTQEYLQ QLESHMKSRK AREQEAREPV LAQLRGLVST LQSATEQMAA TVAGSVRAEV
1210 1220 1230 1240 1250 1260
QHQLHVAVGS LQESILAQVQ RIVKGEVSVA LKEQQAAVTS SIMQAMRSAA GTPVPSAHLD
1270 1280 1290 1300 1310 1320
CQAQQAHILQ LLQQGHLNQA FQQALTAADL NLVLYVCETV DPAQVFGQPP CPLSQPVLLS
1330 1340 1350 1360 1370 1380
LIQQLASDLG TRTDLKLSYL EEAVMHLDHS DPITRDHMGS VMAQVRQKLF QFLQAEPHNS
1390 1400
LGKAARRLSL MLHGLVTPSL P
Protein Neighborhood
Domains & Features
29 N-termini - 8 C-termini - 8 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q6P2E9-2-unknown | MASCAS... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q6P2E9-2-Acetylation | ASCASI... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q6P2E9-2-Acetylation | ASCASI... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q6P2E9-54-unknown | CSGDST... | 54 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14611 | |||
Q6P2E9-58- | STSANK... | 58 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q6P2E9-58-unknown | STSANK... | 58 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12595 | |||
Q6P2E9-58-unknown | STSANK... | 58 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q6P2E9-382-unknown | MWCTVS... | 382 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73627 | |||
Q6P2E9-486-unknown | SLGADG... | 486 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q6P2E9-486-unknown | SLGADG... | 486 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161489 | |||
Q6P2E9-486- | SLGADG... | 486 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q6P2E9-486- | SLGADG... | 486 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q6P2E9-486- | SLGADG... | 486 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q6P2E9-486- | SLGADG... | 486 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q6P2E9-486- | SLGADG... | 486 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q6P2E9-486- | SLGADG... | 486 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q6P2E9-486- | SLGADG... | 486 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q6P2E9-486- | SLGADG... | 486 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q6P2E9-486- | SLGADG... | 486 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q6P2E9-560-unknown | SAAHGS... | 560 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6547 | |||
Q6P2E9-560-unknown | SAAHGS... | 560 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7914 | |||
Q6P2E9-560-unknown | SAAHGS... | 560 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145861 | |||
Q6P2E9-640-unknown | SAVDPS... | 640 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176788 | |||
Q6P2E9-640- | SAVDPS... | 640 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q6P2E9-641-unknown | AVDPSL... | 641 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt167094 | |||
Q6P2E9-641- | AVDPSL... | 641 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q6P2E9-662-unknown | DGSLTM... | 662 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14612 | |||
Q6P2E9-662-unknown | DGSLTM... | 662 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149359 | |||
Q6P2E9-663- | GSLTMS... | 663 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q6P2E9-663- | GSLTMS... | 663 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q6P2E9-663-unknown | GSLTMS... | 663 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q6P2E9-663-unknown | GSLTMS... | 663 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161487 | |||
Q6P2E9-666-unknown | TMSSSG... | 666 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172159 | |||
Q6P2E9-666- | TMSSSG... | 666 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q6P2E9-739- | ALSQDI... | 739 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q6P2E9-739-unknown | ALSQDI... | 739 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173476 | |||
Q6P2E9-768-unknown | SMASAA... | 768 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12596 | |||
Q6P2E9-768-unknown | SMASAA... | 768 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt151772 | |||
Q6P2E9-796-unknown | DGGPGD... | 796 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14614 | |||
Q6P2E9-796-unknown | DGGPGD... | 796 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152240 | |||
Q6P2E9-797- | GGPGDG... | 797 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q6P2E9-797- | GGPGDG... | 797 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q6P2E9-797-unknown | GGPGDG... | 797 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt167092 | |||
Q6P2E9-814-unknown | ALTQEA... | 814 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173478 | |||
Q6P2E9-814- | ALTQEA... | 814 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q6P2E9-874-unknown | ASAEQS... | 874 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175195 | |||
Q6P2E9-874- | ASAEQS... | 874 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q6P2E9-984-unknown | STVTGH... | 984 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7916 | |||
Q6P2E9-984-unknown | STVTGH... | 984 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154628 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...VPDPLC | 53 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14611 | |||
...LCSGDS | 57 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12595 | |||
...SEGLGS | 559 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6547 | |||
...SEGLGS | 559 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7914 | |||
...SEGLGS | 559 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129159 | |||
...PKLQLD | 661 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14612 | |||
...PKLQLD | 661 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132743 | |||
...GLEPDS | 767 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12596 | |||
...GLEPDS | 767 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135176 | |||
...PQLGLD | 795 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14614 | |||
...PQLGLD | 795 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135650 | |||
...LEGLQS | 983 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7916 | |||
...LEGLQS | 983 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138053 | |||
...TPSLP | 1401 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...TPSLP | 1401 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69245 |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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