P52789: Hexokinase-2

General Information

Protein names	- Hexokinase-2 - 2.7.1.1 - Hexokinase type II - HK II - Muscle form hexokinase
Gene names	HK2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P52789

4 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MIASHLLAYF FTELNHDQVQ KVDQYLYHMR LSDETLLEIS KRFRKEMEKG LGATTHPTAA
        70         80         90        100        110        120
VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLWVKVTDN GLQKVEMENQ IYAIPEDIMR
       130        140        150        160        170        180
GSGTQLFDHI AECLANFMDK LQIKDKKLPL GFTFSFPCHQ TKLDESFLVS WTKGFKSSGV
       190        200        210        220        230        240
EGRDVVALIR KAIQRRGDFD IDIVAVVNDT VGTMMTCGYD DHNCEIGLIV GTGSNACYME
       250        260        270        280        290        300
EMRHIDMVEG DEGRMCINME WGAFGDDGSL NDIRTEFDQE IDMGSLNPGK QLFEKMISGM
       310        320        330        340        350        360
YMGELVRLIL VKMAKEELLF GGKLSPELLN TGRFETKDIS DIEGEKDGIR KAREVLMRLG
       370        380        390        400        410        420
LDPTQEDCVA THRICQIVST RSASLCAATL AAVLQRIKEN KGEERLRSTI GVDGSVYKKH
       430        440        450        460        470        480
PHFAKRLHKT VRRLVPGCDV RFLRSEDGSG KGAAMVTAVA YRLADQHRAR QKTLEHLQLS
       490        500        510        520        530        540
HDQLLEVKRR MKVEMERGLS KETHASAPVK MLPTYVCATP DGTEKGDFLA LDLGGTNFRV
       550        560        570        580        590        600
LLVRVRNGKW GGVEMHNKIY AIPQEVMHGT GDELFDHIVQ CIADFLEYMG MKGVSLPLGF
       610        620        630        640        650        660
TFSFPCQQNS LDESILLKWT KGFKASGCEG EDVVTLLKEA IHRREEFDLD VVAVVNDTVG
       670        680        690        700        710        720
TMMTCGFEDP HCEVGLIVGT GSNACYMEEM RNVELVEGEE GRMCVNMEWG AFGDNGCLDD
       730        740        750        760        770        780
FRTEFDVAVD ELSLNPGKQR FEKMISGMYL GEIVRNILID FTKRGLLFRG RISERLKTRG
       790        800        810        820        830        840
IFETKFLSQI ESDCLALLQV RAILQHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA
       850        860        870        880        890        900
VVDRIRENRG LDALKVTVGV DGTLYKLHPH FAKVMHETVK DLAPKCDVSF LQSEDGSGKG
       910
AALITAVACR IREAGQR

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P52789-1-unknown	MIASHL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52789-29-unknown	MRLSDE...	29	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000387140
P52789-53-unknown	ATTHPT...	53	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6004
P52789-53-unknown	ATTHPT...	53	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7550
P52789-692-	NVELVE...	692		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKGLGA	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6004
...EKGLGA	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7550
...EAGQR	917	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	52	GLGA.\|.ATTH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	52	GLGA.\|.ATTH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)