P61201: COP9 signalosome complex subunit 2

General Information

Protein names	- COP9 signalosome complex subunit 2 - SGN2 - Signalosome subunit 2 - Alien homolog - JAB1-containing signalosome subunit 2 - Thyroid receptor-interacting protein 15 - TR-interacting protein 15 - TRIP-15
Gene names	COPS2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P61201

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA LSSFQKVLEL
        70         80         90        100        110        120
EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR SAVTRNYSEK SINSILDYIS
       130        140        150        160        170        180
TSKQMDLLQE FYETTLEALK DAKNDRLWFK TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ
       190        200        210        220        230        240
TDDGEDDLKK GTQLLEIYAL EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC
       250        260        270        280        290        300
GGKMHLREGE FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK
       310        320        330        340        350        360
PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL LRNIRTQVLI
       370        380        390        400        410        420
KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG RIDQVNQLLE LDHQKRGGAR
       430        440
YTALDKWTNQ LNSLNQAVVS KLA

Isoforms

- Isoform 2 of COP9 signalosome complex subunit 2

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P61201-1-unknown	MSDMED...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61201-1-unknown	MSDMED...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71907
P61201-41-unknown	ALKEDD...	41	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178257
P61201-41-	ALKEDD...	41		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P61201-114-unknown	SILDYI...	114	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6080
P61201-178-unknown	SCQTDD...	178	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6082
P61201-178-unknown	SCQTDD...	178	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146080
P61201-407-unknown	QLLELD...	407	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17763
P61201-407-unknown	QLLELD...	407	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152227

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKSINS	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6080
...EKSINS	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126416
...RQLHQS	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6082
...RQLHQS	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129380
...IDQVNQ	406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17763
...IDQVNQ	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135637
...VSKLA	443	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VSKLA	443	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67525

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	113	SINS.\|.SILD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	177	LHQS.\|.SCQT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	406	QVNQ.\|.QLLE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)