P08621: U1 small nuclear ribonucleoprotein 70 kDa

General Information

Protein names	- U1 small nuclear ribonucleoprotein 70 kDa - U1 snRNP 70 kDa {ECO:0000303\|PubMed:3028775} - U1-70K {ECO:0000303\|PubMed:2447561, ECO:0000303\|PubMed:25555158} - snRNP70
Gene names	SNRNP70
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P08621

15 N-termini

9 C-termini

9 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of U1 small nuclear ribonucleoprotein 70 kDa - Isoform 3 of U1 small nuclear ribonucleoprotein 70 kDa - Isoform 4 of U1 small nuclear ribonucleoprotein 70 kDa

Sequence View

        10         20         30         40         50         60
MTQFLPPNLL ALFAPRDPIP YLPPLEKLPH EKHHNQPYCG IAPYIREFED PRDAPPPTRA
        70         80         90        100        110        120
ETREERMERK RREKIERRQQ EVETELKMWD PHNDPNAQGD AFKTLFVARV NYDTTESKLR
       130        140        150        160        170        180
REFEVYGPIK RIHMVYSKRS GKPRGYAFIE YEHERDMHSA YKHADGKKID GRRVLVDVER
       190        200        210        220        230        240
GRTVKGWRPR RLGGGLGGTR RGGADVNIRH SGRDDTSRYD ERPGPSPLPH RDRDRDRERE
       250        260        270        280        290        300
RRERSRERDK ERERRRSRSR DRRRRSRSRD KEERRRSRER SKDKDRDRKR RSSRSRERAR
       310        320        330        340        350        360
RERERKEELR GGGGDMAEPS EAGDAPPDDG PPGELGPDGP DGPEEKGRDR DRERRRSHRS
       370        380        390        400        410        420
ERERRRDRDR DRDRDREHKR GERGSERGRD EARGGGGGQD NGLEGLGNDS RDMYMESEGG
       430
DGYLAPENGY LMEAAPE         10         20         30         40         50         60
MTQFLPPNLL ALFAPRDPIP YLPPLEKLPH EKHHNQPYCG IAPYIREFED PRDAPPPTRA
        70         80         90        100        110        120
ETREERMERK RREKIERRQQ EVETELKMWD PHNDPNAQGD AFKTLFVARV NYDTTESKLR
       130        140        150        160        170        180
REFEVYGPIK RIHMVYSKRS GKPRGYAFIE YEHERDMHSA YKHADGKKID GRRVLVDVER
       190        200        210        220        230        240
GRTVKGWRPR RLGGGLGGTR RGGADVNIRH SGRDDTSRYD ERPGPSPLPH RDRDRDRERE
       250        260        270        280        290        300
RRERSRERDK ERERRRSRSR DRRRRSRSRD KEERRRSRER SKDKDRDRKR RSSRSRERAR
       310        320        330        340        350        360
RERERKEELR GGGGDMAEPS EAGDAPPDDG PPGELGPDGP DGPEEKGRDR DRERRRSHRS
       370        380        390        400        410        420
ERERRRDRDR DRDRDREHKR GERGSERGRD EARGGGGGQD NGLEGLGNDS RDMYMESEGG
       430
DGYLAPENGY LMEAAPE         10         20         30         40         50         60
MTQFLPPNLL ALFAPRDPIP YLPPLEKLPH EKHHNQPYCG IAPYIREFED PRDAPPPTRA
        70         80         90        100        110        120
ETREERMERK RREKIERRQQ EVETELKMWD PHNDPNAQGD AFKTLFVARV NYDTTESKLR
       130        140        150        160        170        180
REFEVYGPIK RIHMVYSKRS GKPRGYAFIE YEHERDMHSA YKHADGKKID GRRVLVDVER
       190        200        210        220        230        240
GRTVKGWRPR RLGGGLGGTR RGGADVNIRH SGRDDTSRYD ERPGPSPLPH RDRDRDRERE
       250        260        270        280        290        300
RRERSRERDK ERERRRSRSR DRRRRSRSRD KEERRRSRER SKDKDRDRKR RSSRSRERAR
       310        320        330        340        350        360
RERERKEELR GGGGDMAEPS EAGDAPPDDG PPGELGPDGP DGPEEKGRDR DRERRRSHRS
       370        380        390        400        410        420
ERERRRDRDR DRDRDREHKR GERGSERGRD EARGGGGGQD NGLEGLGNDS RDMYMESEGG
       430
DGYLAPENGY LMEAAPE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

15 N-termini - 9 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P08621-1-unknown	MTQFLP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88369
P08621-1-unknown	MTQFLP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88370
P08621-2-unknown	MTQFLP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08621-2-Acetylation	TQFLPP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08621-2-Acetylation	TQFLPP...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P08621-2-Acetylation	TQFLPP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110958
P08621-2-Acetylation	TQFLPP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110959
P08621-40-	GIAPYI...	40			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08621-40-unknown	GIAPYI...	40		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174348
P08621-40-unknown	GIAPYI...	40		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174349
P08621-88-	MWDPHN...	88			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P08621-88-unknown	MWDPHN...	88		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178051
P08621-88-unknown	MWDPHN...	88		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178052
P08621-148-unknown	FIEYEH...	148		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5509
P08621-148-unknown	FIEYEH...	148		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3541
P08621-148-unknown	FIEYEH...	148		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144646
P08621-221-unknown	ERPGPS...	221		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17227
P08621-221-unknown	ERPGPS...	221		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143698
P08621-317-unknown	AEPSEA...	317		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11119
P08621-317-unknown	AEPSEA...	317		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147385
P08621-317-unknown	AEPSEA...	317		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150077
P08621-342-unknown	GPEEKG...	342		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1610
P08621-342-unknown	GPEEKG...	342		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148287
P08621-342-unknown	GPEEKG...	342		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150582
P08621-394-unknown	GGGGGQ...	394		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9951
P08621-394-unknown	GGGGGQ...	394		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149823
P08621-394-unknown	GGGGGQ...	394		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151749
P08621-407-unknown	GNDSRD...	407		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13943
P08621-407-unknown	GNDSRD...	407		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150139
P08621-407-unknown	GNDSRD...	407		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151973
P08621-410-unknown	SRDMYM...	410		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11122
P08621-410-unknown	SRDMYM...	410		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150206
P08621-410-unknown	SRDMYM...	410		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152015
P08621-428-unknown	NGYLME...	428		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11125
P08621-428-unknown	NGYLME...	428		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150567
P08621-428-unknown	NGYLME...	428		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152319

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PRGYAF	147	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5509
...PRGYAF	147	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3541
...PRGYAF	147	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127911
...PRGYAF	147	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127913
...TSRYDE	220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17227
...TSRYDE	220	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126941
...TSRYDE	220	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154663
...GGGDMA	316	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11119
...GGGDMA	316	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130732
...GGGDMA	316	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133469
...PDGPDG	341	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1610
...PDGPDG	341	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131657
...PDGPDG	341	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133979
...RDEARG	393	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9951
...RDEARG	393	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133214
...RDEARG	393	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135154
...GLEGLG	406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13943
...GLEGLG	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133531
...GLEGLG	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135381
...GLGNDS	409	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11122
...GLGNDS	409	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133600
...GLGNDS	409	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135424
...YLAPEN	427	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11125
...YLAPEN	427	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133964
...YLAPEN	427	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135730
...EAAPE	437	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EAAPE	437	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83989
...EAAPE	437	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83987

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	147	GYAF.\|.FIEY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	147	GYAF.\|.FIEY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	220	RYDE.\|.ERPG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	316	GDMA.\|.AEPS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP3_HUMAN	341	GPDG.\|.GPEE	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> RU17_HUMAN @341
GRAA_HUMAN	393	EARG.\|.GGGG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	406	EGLG.\|.GNDS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	409	GNDS.\|.SRDM	inferred from experiment	unknown	MEROPS	Rosen A	Casciola-Rosen L et al.:Cleavage by granzyme B is stron... (S01.010)	10499920,
GRAB_HUMAN	427	APEN.\|.NGYL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)