Q6NVY1: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

General Information

Protein names	- 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial - 3.1.2.4 - 3-hydroxyisobutyryl-coenzyme A hydrolase - HIB-CoA hydrolase - HIBYL-CoA-H
Gene names	HIBCH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6NVY1

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGQREMWRLM SRFNAFKRTN TILHHLRMSK HTDAAEEVLL EKKGCTGVIT LNRPKFLNAL
        70         80         90        100        110        120
TLNMIRQIYP QLKKWEQDPE TFLIIIKGAG GKAFCAGGDI RVISEAEKAK QKIAPVFFRE
       130        140        150        160        170        180
EYMLNNAVGS CQKPYVALIH GITMGGGVGL SVHGQFRVAT EKCLFAMPET AIGLFPDVGG
       190        200        210        220        230        240
GYFLPRLQGK LGYFLALTGF RLKGRDVYRA GIATHFVDSE KLAMLEEDLL ALKSPSKENI
       250        260        270        280        290        300
ASVLENYHTE SKIDRDKSFI LEEHMDKINS CFSANTVEEI IENLQQDGSS FALEQLKVIN
       310        320        330        340        350        360
KMSPTSLKIT LRQLMEGSSK TLQEVLTMEY RLSQACMRGH DFHEGVRAVL IDKDQSPKWK
       370        380
PADLKEVTEE DLNNHFKSLG SSDLKF

Isoforms

- Isoform 2 of 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6NVY1-1-unknown	MGQREM...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76983
Q6NVY1-30-	KHTDAA...	30		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q6NVY1-30-	KHTDAA...	30		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q6NVY1-30-	KHTDAA...	30		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q6NVY1-30-	KHTDAA...	30		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q6NVY1-30-	KHTDAA...	30		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6NVY1-30-	KHTDAA...	30		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q6NVY1-30-	KHTDAA...	30		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q6NVY1-30-	KHTDAA...	30		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q6NVY1-30-	KHTDAA...	30		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q6NVY1-30-unknown	KHTDAA...	30		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q6NVY1-30-unknown	KHTDAA...	30		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q6NVY1-30-unknown	KHTDAA...	30	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159714
Q6NVY1-33-unknown	DAAEEV...	33	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6NVY1-33-unknown	DAAEEV...	33	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115091
Q6NVY1-33-unknown	DAAEEV...	33	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q6NVY1-214-unknown	THFVDS...	214	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6545
Q6NVY1-214-unknown	THFVDS...	214	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147144

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RAGIAT	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6545
...RAGIAT	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130479
...SDLKF	386	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	213	GIAT.\|.THFV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)