Q9P2T1: GMP reductase 2 {ECO:0000255|HAMAP-Rule:MF_03195}
Protein names | - GMP reductase 2 {ECO:0000255|HAMAP-Rule:MF_03195} - GMPR 2 {ECO:0000255|HAMAP-Rule:MF_03195} - 1.7.1.7 {ECO:0000255|HAMAP-Rule:MF_03195} - Guanosine 5'-monophosphate oxidoreductase 2 {ECO:0000255|HAMAP-Rule:MF_03195} - Guanosine monophosphate reductase 2 {ECO:0000255|HAMAP-Rule:MF_03195} |
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Gene names | GMPR2 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9P2T1 |
5
N-termini
7
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT
70 80 90 100 110 120
FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI
130 140 150 160 170 180
PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI
190 200 210 220 230 240
GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM
250 260 270 280 290 300
LGGMLAGHSE SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD
310 320 330 340
VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSEAC
Isoforms
- Isoform 2 of GMP reductase 2 - Isoform 3 of GMP reductase 2Sequence View
10 20 30 40 50 60
MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT
70 80 90 100 110 120
FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI
130 140 150 160 170 180
PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI
190 200 210 220 230 240
GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM
250 260 270 280 290 300
LGGMLAGHSE SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD
310 320 330 340
VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSEAC
10 20 30 40 50 60
MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT
70 80 90 100 110 120
FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI
130 140 150 160 170 180
PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI
190 200 210 220 230 240
GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM
250 260 270 280 290 300
LGGMLAGHSE SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD
310 320 330 340
VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSEAC
Protein Neighborhood
Domains & Features
5 N-termini - 7 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9P2T1-1-unknown | MPHIDN... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9P2T1-1-unknown | MPHIDN... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt76136 | |||
Q9P2T1-1-unknown | MPHIDN... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt95907 | |||
Q9P2T1-55-unknown | MDTVGT... | 55 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000453079 | |||
Q9P2T1-55-unknown | MDTVGT... | 55 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt196226 | |||
Q9P2T1-141-unknown | FVKDVR... | 141 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000453139 | |||
Q9P2T1-141-unknown | FVKDVR... | 141 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt197549 | |||
Q9P2T1-141-unknown | FVKDVR... | 141 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt197550 | |||
Q9P2T1-155-unknown | MAGNVV... | 155 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000454138 | |||
Q9P2T1-155-unknown | MAGNVV... | 155 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt197665 | |||
Q9P2T1-155-unknown | MAGNVV... | 155 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt197666 | |||
Q9P2T1-247-unknown | GHSESG... | 247 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6830 | |||
Q9P2T1-247-unknown | GHSESG... | 247 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147323 | |||
Q9P2T1-247-unknown | GHSESG... | 247 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148999 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...SSDFEQ | 111 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000453079 | |||
...SSDFEQ | 111 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt154492 | |||
...QHTIMA | 155 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000453761 | |||
...QHTIMA | 155 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155033 | |||
...QHTIMA | 155 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155034 | |||
...TGVGYP | 196 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000454009 | |||
...TGVGYP | 196 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155571 | |||
...TGVGYP | 196 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155572 | |||
...GGMLAG | 246 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6830 | |||
...GGMLAG | 246 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130666 | |||
...GGMLAG | 246 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132381 | |||
...MKKYAG | 279 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000454138 | |||
...FSEAC | 348 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...FSEAC | 348 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt71754 | |||
...FSEAC | 348 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt71753 | |||
...FSEAC | 348 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...FSEAC | 348 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, | |||
...FSEAC | 348 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...FSEAC | 348 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 246 | MLAG.|.GHSE | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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