Q9HAV4: Exportin-5

General Information

Protein names	- Exportin-5 - Exp5 - Ran-binding protein 21
Gene names	XPO5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9HAV4

6 N-termini

6 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAMDQVNALC EQLVKAVTVM MDPNSTQRYR LEALKFCEEF KEKCPICVPC GLRLAEKTQV
        70         80         90        100        110        120
AIVRHFGLQI LEHVVKFRWN GMSRLEKVYL KNSVMELIAN GTLNILEEEN HIKDALSRIV
       130        140        150        160        170        180
VEMIKREWPQ HWPDMLIELD TLSKQGETQT ELVMFILLRL AEDVVTFQTL PPQRRRDIQQ
       190        200        210        220        230        240
TLTQNMERIF SFLLNTLQEN VNKYQQVKTD TSQESKAQAN CRVGVAALNT LAGYIDWVSM
       250        260        270        280        290        300
SHITAENCKL LEILCLLLNE QELQLGAAEC LLIAVSRKGK LEDRKPLMVL FGDVAMHYIL
       310        320        330        340        350        360
SAAQTADGGG LVEKHYVFLK RLCQVLCALG NQLCALLGAD SDVETPSNFG KYLESFLAFT
       370        380        390        400        410        420
THPSQFLRSS TQMTWGALFR HEILSRDPLL LAIIPKYLRA SMTNLVKMGF PSKTDSPSCE
       430        440        450        460        470        480
YSRFDFDSDE DFNAFFNSSR AQQGEVMRLA CRLDPKTSFQ MAGEWLKYQL STFLDAGSVN
       490        500        510        520        530        540
SCSAVGTGEG SLCSVFSPSF VQWEAMTLFL ESVITQMFRT LNREEIPVND GIELLQMVLN
       550        560        570        580        590        600
FDTKDPLILS CVLTNVSALF PFVTYRPEFL PQVFSKLFSS VTFETVEESK APRTRAVRNV
       610        620        630        640        650        660
RRHACSSIIK MCRDYPQLVL PNFDMLYNHV KQLLSNELLL TQMEKCALME ALVLISNQFK
       670        680        690        700        710        720
NYERQKVFLE ELMAPVASIW LSQDMHRVLS DVDAFIAYVG TDQKSCDPGL EDPCGLNRAR
       730        740        750        760        770        780
MSFCVYSILG VVKRTCWPTD LEEAKAGGFV VGYTSSGNPI FRNPCTEQIL KLLDNLLALI
       790        800        810        820        830        840
RTHNTLYAPE MLAKMAEPFT KALDMLDAEK SAILGLPQPL LELNDSPVFK TVLERMQRFF
       850        860        870        880        890        900
STLYENCFHI LGKAGPSMQQ DFYTVEDLAT QLLSSAFVNL NNIPDYRLRP MLRVFVKPLV
       910        920        930        940        950        960
LFCPPEHYEA LVSPILGPLF TYLHMRLSQK WQVINQRSLL CGEDEAADEN PESQEMLEEQ
       970        980        990       1000       1010       1020
LVRMLTREVM DLITVCCVSK KGADHSSAPP ADGDDEEMMA TEVTPSAMAE LTDLGKCLMK
      1030       1040       1050       1060       1070       1080
HEDVCTALLI TAFNSLAWKD TLSCQRTTSQ LCWPLLKQVL SGTLLADAVT WLFTSVLKGL
      1090       1100       1110       1120       1130       1140
QMHGQHDGCM ASLVHLAFQI YEALRPRYLE IRAVMEQIPE IQKDSLDQFD CKLLNPSLQK
      1150       1160       1170       1180       1190       1200
VADKRRKDQF KRLIAGCIGK PLGEQFRKEV HIKNLPSLFK KTKPMLETEV LDNDGGGLAT

IFEP

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 6 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9HAV4-2-unknown	MAMDQV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9HAV4-2-Acetylation	AMDQVN...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9HAV4-2-Acetylation	AMDQVN...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9HAV4-2-Acetylation	AMDQVN...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9HAV4-2-Acetylation	AMDQVN...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9HAV4-211-unknown	TSQESK...	211		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13353
Q9HAV4-302-unknown	AAQTAD...	302		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6786
Q9HAV4-945-unknown	EAADEN...	945		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13354
Q9HAV4-1125-unknown	SLDQFD...	1125		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13355

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QVKTDT	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13353
...HYILSA	301	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6786
...LCGEDE	944	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13354
...EIQKDS	1124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13355
...LNPSLQ	1138	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000387384
...TIFEP	1204	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	210	KTDT.\|.TSQE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	301	ILSA.\|.AAQT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	944	GEDE.\|.EAAD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	1124	QKDS.\|.SLDQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)