Q9H2P9: Diphthine methyl ester synthase

General Information

Protein names	- Diphthine methyl ester synthase - 2.1.1.314 - Diphthamide biosynthesis methyltransferase
Gene names	DPH5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H2P9

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Diphthine synthase - Isoform 3 of Diphthine synthase - Isoform 4 of Diphthine synthase - Isoform 5 of Diphthine synthase - Isoform 6 of Diphthine synthase - Isoform 2 of Diphthine methyl ester synthase - Isoform 3 of Diphthine methyl ester synthase - Isoform 4 of Diphthine methyl ester synthase - Isoform 5 of Diphthine methyl ester synthase - Isoform 6 of Diphthine methyl ester synthase

Sequence View

        10         20         30         40         50         60
MLYLIGLGLG DAKDITVKGL EVVRRCSRVY LEAYTSVLTV GKEALEEFYG RKLVVADREE
        70         80         90        100        110        120
VEQEADNILK DADISDVAFL VVGDPFGATT HSDLVLRATK LGIPYRVIHN ASIMNAVGCC
       130        140        150        160        170        180
GLQLYKFGET VSIVFWTDTW RPESFFDKVK KNRQNGMHTL CLLDIKVKEQ SLENLIKGRK
       190        200        210        220        230        240
IYEPPRYMSV NQAAQQLLEI VQNQRIRGEE PAVTEETLCV GLARVGADDQ KIAAGTLRQM
       250        260        270        280
CTVDLGEPLH SLIITGGSIH PMEMEMLSLF SIPENSSESQ SINGL         10         20         30         40         50         60
MLYLIGLGLG DAKDITVKGL EVVRRCSRVY LEAYTSVLTV GKEALEEFYG RKLVVADREE
        70         80         90        100        110        120
VEQEADNILK DADISDVAFL VVGDPFGATT HSDLVLRATK LGIPYRVIHN ASIMNAVGCC
       130        140        150        160        170        180
GLQLYKFGET VSIVFWTDTW RPESFFDKVK KNRQNGMHTL CLLDIKVKEQ SLENLIKGRK
       190        200        210        220        230        240
IYEPPRYMSV NQAAQQLLEI VQNQRIRGEE PAVTEETLCV GLARVGADDQ KIAAGTLRQM
       250        260        270        280
CTVDLGEPLH SLIITGGSIH PMEMEMLSLF SIPENSSESQ SINGL         10         20         30         40         50         60
MLYLIGLGLG DAKDITVKGL EVVRRCSRVY LEAYTSVLTV GKEALEEFYG RKLVVADREE
        70         80         90        100        110        120
VEQEADNILK DADISDVAFL VVGDPFGATT HSDLVLRATK LGIPYRVIHN ASIMNAVGCC
       130        140        150        160        170        180
GLQLYKFGET VSIVFWTDTW RPESFFDKVK KNRQNGMHTL CLLDIKVKEQ SLENLIKGRK
       190        200        210        220        230        240
IYEPPRYMSV NQAAQQLLEI VQNQRIRGEE PAVTEETLCV GLARVGADDQ KIAAGTLRQM
       250        260        270        280
CTVDLGEPLH SLIITGGSIH PMEMEMLSLF SIPENSSESQ SINGL         10         20         30         40         50         60
MLYLIGLGLG DAKDITVKGL EVVRRCSRVY LEAYTSVLTV GKEALEEFYG RKLVVADREE
        70         80         90        100        110        120
VEQEADNILK DADISDVAFL VVGDPFGATT HSDLVLRATK LGIPYRVIHN ASIMNAVGCC
       130        140        150        160        170        180
GLQLYKFGET VSIVFWTDTW RPESFFDKVK KNRQNGMHTL CLLDIKVKEQ SLENLIKGRK
       190        200        210        220        230        240
IYEPPRYMSV NQAAQQLLEI VQNQRIRGEE PAVTEETLCV GLARVGADDQ KIAAGTLRQM
       250        260        270        280
CTVDLGEPLH SLIITGGSIH PMEMEMLSLF SIPENSSESQ SINGL         10         20         30         40         50         60
MLYLIGLGLG DAKDITVKGL EVVRRCSRVY LEAYTSVLTV GKEALEEFYG RKLVVADREE
        70         80         90        100        110        120
VEQEADNILK DADISDVAFL VVGDPFGATT HSDLVLRATK LGIPYRVIHN ASIMNAVGCC
       130        140        150        160        170        180
GLQLYKFGET VSIVFWTDTW RPESFFDKVK KNRQNGMHTL CLLDIKVKEQ SLENLIKGRK
       190        200        210        220        230        240
IYEPPRYMSV NQAAQQLLEI VQNQRIRGEE PAVTEETLCV GLARVGADDQ KIAAGTLRQM
       250        260        270        280
CTVDLGEPLH SLIITGGSIH PMEMEMLSLF SIPENSSESQ SINGL         10         20         30         40         50         60
MLYLIGLGLG DAKDITVKGL EVVRRCSRVY LEAYTSVLTV GKEALEEFYG RKLVVADREE
        70         80         90        100        110        120
VEQEADNILK DADISDVAFL VVGDPFGATT HSDLVLRATK LGIPYRVIHN ASIMNAVGCC
       130        140        150        160        170        180
GLQLYKFGET VSIVFWTDTW RPESFFDKVK KNRQNGMHTL CLLDIKVKEQ SLENLIKGRK
       190        200        210        220        230        240
IYEPPRYMSV NQAAQQLLEI VQNQRIRGEE PAVTEETLCV GLARVGADDQ KIAAGTLRQM
       250        260        270        280
CTVDLGEPLH SLIITGGSIH PMEMEMLSLF SIPENSSESQ SINGL         10         20         30         40         50         60
MLYLIGLGLG DAKDITVKGL EVVRRCSRVY LEAYTSVLTV GKEALEEFYG RKLVVADREE
        70         80         90        100        110        120
VEQEADNILK DADISDVAFL VVGDPFGATT HSDLVLRATK LGIPYRVIHN ASIMNAVGCC
       130        140        150        160        170        180
GLQLYKFGET VSIVFWTDTW RPESFFDKVK KNRQNGMHTL CLLDIKVKEQ SLENLIKGRK
       190        200        210        220        230        240
IYEPPRYMSV NQAAQQLLEI VQNQRIRGEE PAVTEETLCV GLARVGADDQ KIAAGTLRQM
       250        260        270        280
CTVDLGEPLH SLIITGGSIH PMEMEMLSLF SIPENSSESQ SINGL         10         20         30         40         50         60
MLYLIGLGLG DAKDITVKGL EVVRRCSRVY LEAYTSVLTV GKEALEEFYG RKLVVADREE
        70         80         90        100        110        120
VEQEADNILK DADISDVAFL VVGDPFGATT HSDLVLRATK LGIPYRVIHN ASIMNAVGCC
       130        140        150        160        170        180
GLQLYKFGET VSIVFWTDTW RPESFFDKVK KNRQNGMHTL CLLDIKVKEQ SLENLIKGRK
       190        200        210        220        230        240
IYEPPRYMSV NQAAQQLLEI VQNQRIRGEE PAVTEETLCV GLARVGADDQ KIAAGTLRQM
       250        260        270        280
CTVDLGEPLH SLIITGGSIH PMEMEMLSLF SIPENSSESQ SINGL         10         20         30         40         50         60
MLYLIGLGLG DAKDITVKGL EVVRRCSRVY LEAYTSVLTV GKEALEEFYG RKLVVADREE
        70         80         90        100        110        120
VEQEADNILK DADISDVAFL VVGDPFGATT HSDLVLRATK LGIPYRVIHN ASIMNAVGCC
       130        140        150        160        170        180
GLQLYKFGET VSIVFWTDTW RPESFFDKVK KNRQNGMHTL CLLDIKVKEQ SLENLIKGRK
       190        200        210        220        230        240
IYEPPRYMSV NQAAQQLLEI VQNQRIRGEE PAVTEETLCV GLARVGADDQ KIAAGTLRQM
       250        260        270        280
CTVDLGEPLH SLIITGGSIH PMEMEMLSLF SIPENSSESQ SINGL         10         20         30         40         50         60
MLYLIGLGLG DAKDITVKGL EVVRRCSRVY LEAYTSVLTV GKEALEEFYG RKLVVADREE
        70         80         90        100        110        120
VEQEADNILK DADISDVAFL VVGDPFGATT HSDLVLRATK LGIPYRVIHN ASIMNAVGCC
       130        140        150        160        170        180
GLQLYKFGET VSIVFWTDTW RPESFFDKVK KNRQNGMHTL CLLDIKVKEQ SLENLIKGRK
       190        200        210        220        230        240
IYEPPRYMSV NQAAQQLLEI VQNQRIRGEE PAVTEETLCV GLARVGADDQ KIAAGTLRQM
       250        260        270        280
CTVDLGEPLH SLIITGGSIH PMEMEMLSLF SIPENSSESQ SINGL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9H2P9-1-unknown	MLYLIG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H2P9-1-unknown	MLYLIG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73183
Q9H2P9-1-unknown	MLYLIG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73184
Q9H2P9-1-unknown	MLYLIG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73185
Q9H2P9-1-unknown	MLYLIG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73186
Q9H2P9-1-unknown	MLYLIG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73187
Q9H2P9-88-unknown	ATTHSD...	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6774
Q9H2P9-88-unknown	ATTHSD...	88	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141713
Q9H2P9-88-unknown	ATTHSD...	88	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141715
Q9H2P9-88-unknown	ATTHSD...	88	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141716
Q9H2P9-88-unknown	ATTHSD...	88	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H2P9-88-unknown	ATTHSD...	88	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GDPFGA	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6774
...GDPFGA	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124895
...GDPFGA	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124897
...GDPFGA	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124898
...GDPFGA	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154234
...SINGL	285	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SINGL	285	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68801
...SINGL	285	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68802
...SINGL	285	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68805
...SINGL	285	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68803
...SINGL	285	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68804

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	87	PFGA.\|.ATTH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)