O00203: AP-3 complex subunit beta-1

General Information

Protein names	- AP-3 complex subunit beta-1 - Adaptor protein complex AP-3 subunit beta-1 - Adaptor-related protein complex 3 subunit beta-1 - Beta-3A-adaptin - Clathrin assembly protein complex 3 beta-1 large chain
Gene names	AP3B1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00203

5 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSNSFPYNE QSGGGEATEL GQEATSTISP SGAFGLFSSD LKKNEDLKQM LESNKDSAKL
        70         80         90        100        110        120
DAMKRIVGMI AKGKNASELF PAVVKNVASK NIEIKKLVYV YLVRYAEEQQ DLALLSISTF
       130        140        150        160        170        180
QRALKDPNQL IRASALRVLS SIRVPIIVPI MMLAIKEASA DLSPYVRKNA AHAIQKLYSL
       190        200        210        220        230        240
DPEQKEMLIE VIEKLLKDKS TLVAGSVVMA FEEVCPDRID LIHKNYRKLC NLLVDVEEWG
       250        260        270        280        290        300
QVVIIHMLTR YARTQFVSPW KEGDELEDNG KNFYESDDDQ KEKTDKKKKP YTMDPDHRLL
       310        320        330        340        350        360
IRNTKPLLQS RNAAVVMAVA QLYWHISPKS EAGIISKSLV RLLRSNREVQ YIVLQNIATM
       370        380        390        400        410        420
SIQRKGMFEP YLKSFYVRST DPTMIKTLKL EILTNLANEA NISTLLREFQ TYVKSQDKQF
       430        440        450        460        470        480
AAATIQTIGR CATNILEVTD TCLNGLVCLL SNRDEIVVAE SVVVIKKLLQ MQPAQHGEII
       490        500        510        520        530        540
KHMAKLLDSI TVPVARASIL WLIGENCERV PKIAPDVLRK MAKSFTSEDD LVKLQILNLG
       550        560        570        580        590        600
AKLYLTNSKQ TKLLTQYILN LGKYDQNYDI RDRTRFIRQL IVPNVKSGAL SKYAKKIFLA
       610        620        630        640        650        660
QKPAPLLESP FKDRDHFQLG TLSHTLNIKA TGYLELSNWP EVAPDPSVRN VEVIELAKEW
       670        680        690        700        710        720
TPAGKAKQEN SAKKFYSESE EEEDSSDSSS DSESESGSES GEQGESGEEG DSNEDSSEDS
       730        740        750        760        770        780
SSEQDSESGR ESGLENKRTA KRNSKAKGKS DSEDGEKENE KSKTSDSSND ESSSIEDSSS
       790        800        810        820        830        840
DSESESEPES ESESRRVTKE KEKKTKQDRT PLTKDVSLLD LDDFNPVSTP VALPTPALSP
       850        860        870        880        890        900
SLMADLEGLH LSTSSSVISV STPAFVPTKT HVLLHRMSGK GLAAHYFFPR QPCIFGDKMV
       910        920        930        940        950        960
SIQITLNNTT DRKIENIHIG EKKLPIGMKM HVFNPIDSLE PEGSITVSMG IDFCDSTQTA
       970        980        990       1000       1010       1020
SFQLCTKDDC FNVNIQPPVG ELLLPVAMSE KDFKKEQGVL TGMNETSAVI IAAPQNFTPS
      1030       1040       1050       1060       1070       1080
VIFQKVVNVA NVGAVPSGQD NIHRFAAKTV HSGSLMLVTV ELKEGSTAQL IINTEKTVIG
      1090
SVLLRELKPV LSQG

Isoforms

- Isoform 2 of AP-3 complex subunit beta-1

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O00203-1-unknown	MSSNSF...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00203-50-unknown	MLESNK...	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67155
O00203-50-unknown	MLESNK...	50	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430597
O00203-471-unknown	MQPAQH...	471	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5082
O00203-471-unknown	MQPAQH...	471	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152375
O00203-1031-unknown	NVGAVP...	1031	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3243
O00203-1031-unknown	NVGAVP...	1031	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157114
O00203-1034-unknown	AVPSGQ...	1034	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6982
O00203-1034-unknown	AVPSGQ...	1034	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5084
O00203-1034-unknown	AVPSGQ...	1034	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157120

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KKLLQM	470	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5082
...KKLLQM	470	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt135786
...VVNVAN	1030	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3243
...VVNVAN	1030	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140614
...VANVGA	1033	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6982
...VANVGA	1033	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5084
...VANVGA	1033	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140620
...VLSQG	1094	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...VLSQG	1094	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt62773
...VLSQG	1094		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VLSQG	1094		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...VLSQG	1094		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VLSQG	1094		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	470	LLQM.\|.MQPA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	1030	NVAN.\|.NVGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	1033	NVGA.\|.AVPS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	1033	NVGA.\|.AVPS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)