O15067: Phosphoribosylformylglycinamidine synthase

General Information

Protein names	- Phosphoribosylformylglycinamidine synthase - FGAM synthase - FGAMS - 6.3.5.3 - Formylglycinamide ribonucleotide amidotransferase - FGAR amidotransferase - FGAR-AT - Formylglycinamide ribotide amidotransferase
Gene names	PFAS
Organism	Homo sapiens
Protease Family
Protease ID	C56.972
Chromosome location
UniProt ID	O15067

14 N-termini

14 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSPVLHFYVR PSGHEGAAPG HTRRKLQGKL PELQGVETEL CYNVNWTAEA LPSAEETKKL
        70         80         90        100        110        120
MWLFGCPLLL DDVARESWLL PGSNDLLLEV GPRLNFSTPT STNIVSVCRA TGLGPVDRVE
       130        140        150        160        170        180
TTRRYRLSFA HPPSAEVEAI ALATLHDRMT EQHFPHPIQS FSPESMPEPL NGPINILGEG
       190        200        210        220        230        240
RLALEKANQE LGLALDSWDL DFYTKRFQEL QRNPSTVEAF DLAQSNSEHS RHWFFKGQLH
       250        260        270        280        290        300
VDGQKLVHSL FESIMSTQES SNPNNVLKFC DNSSAIQGKE VRFLRPEDPT RPSRFQQQQG
       310        320        330        340        350        360
LRHVVFTAET HNFPTGVCPF SGATTGTGGR IRDVQCTGRG AHVVAGTAGY CFGNLHIPGY
       370        380        390        400        410        420
NLPWEDPSFQ YPGNFARPLE VAIEASNGAS DYGNKFGEPV LAGFARSLGL QLPDGQRREW
       430        440        450        460        470        480
IKPIMFSGGI GSMEADHISK EAPEPGMEVV KVGGPVYRIG VGGGAASSVQ VQGDNTSDLD
       490        500        510        520        530        540
FGAVQRGDPE MEQKMNRVIR ACVEAPKGNP ICSLHDQGAG GNGNVLKELS DPAGAIIYTS
       550        560        570        580        590        600
RFQLGDPTLN ALEIWGAEYQ ESNALLLRSP NRDFLTHVSA RERCPACFVG TITGDRRIVL
       610        620        630        640        650        660
VDDRECPVRR NGQGDAPPTP LPTPVDLELE WVLGKMPRKE FFLQRKPPML QPLALPPGLS
       670        680        690        700        710        720
VHQALERVLR LPAVASKRYL TNKVDRSVGG LVAQQQCVGP LQTPLADVAV VALSHEELIG
       730        740        750        760        770        780
AATALGEQPV KSLLDPKVAA RLAVAEALTN LVFALVTDLR DVKCSGNWMW AAKLPGEGAA
       790        800        810        820        830        840
LADACEAMVA VMAALGVAVD GGKDSLSMAA RVGTETVRAP GSLVISAYAV CPDITATVTP
       850        860        870        880        890        900
DLKHPEGRGH LLYVALSPGQ HRLGGTALAQ CFSQLGEHPP DLDLPENLVR AFSITQGLLK
       910        920        930        940        950        960
DRLLCSGHDV SDGGLVTCLL EMAFAGNCGL QVDVPVPRVD VLSVLFAEEP GLVLEVQEPD
       970        980        990       1000       1010       1020
LAQVLKRYRD AGLHCLELGH TGEAGPHAMV RVSVNGAVVL EEPVGELRAL WEETSFQLDR
      1030       1040       1050       1060       1070       1080
LQAEPRCVAE EERGLRERMG PSYCLPPTFP KASVPREPGG PSPRVAILRE EGSNGDREMA
      1090       1100       1110       1120       1130       1140
DAFHLAGFEV WDVTMQDLCS GAIGLDTFRG VAFVGGFSYA DVLGSAKGWA AAVTFHPRAG
      1150       1160       1170       1180       1190       1200
AELRRFRKRP DTFSLGVCNG CQLLALLGWV GGDPNEDAAE MGPDSQPARP GLLLRHNLSG
      1210       1220       1230       1240       1250       1260
RYESRWASVR VGPGPALMLR GMEGAVLPVW SAHGEGYVAF SSPELQAQIE ARGLAPLHWA
      1270       1280       1290       1300       1310       1320
DDDGNPTEQY PLNPNGSPGG VAGICSCDGR HLAVMPHPER AVRPWQWAWR PPPFDTLTTS
      1330
PWLQLFINAR NWTLEGSC

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

14 N-termini - 14 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15067-1-unknown	MSPVLH...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15067-256-unknown	STQESS...	256	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5138
O15067-425-unknown	MFSGGI...	425	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000441706
O15067-429-unknown	GIGSME...	429	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3263
O15067-475-unknown	NTSDLD...	475	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10702
O15067-513-unknown	SLHDQG...	513	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7011
O15067-514-unknown	LHDQGA...	514	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7012
O15067-721-unknown	AATALG...	721	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3264
O15067-877-unknown	EHPPDL...	877	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5139
O15067-978-unknown	LGHTGE...	978	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3265
O15067-980-unknown	HTGEAG...	980	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5140
O15067-996-	GAVVLE...	996		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15067-996-	GAVVLE...	996		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O15067-996-	GAVVLE...	996		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O15067-996-	GAVVLE...	996		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O15067-998-	VVLEEP...	998		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15067-1052-unknown	ASVPRE...	1052	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5141

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SNDLLL	87	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463362
...PTSTNI	103	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463045
...HPPSAE	135	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464689
...FESIMS	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5138
...IMFSGG	428	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3263
...QVQGDN	474	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10702
...GNPICS	512	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7011
...NPICSL	513	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7012
...EELIGA	720	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3264
...FSQLGE	876	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5139
...LHCLEL	977	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3265
...CLELGH	979	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5140
...PTFPKA	1051	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5141
...LEGSC	1338	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	255	SIMS.\|.STQE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	428	FSGG.\|.GIGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	474	QGDN.\|.NTSD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	512	PICS.\|.SLHD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	513	ICSL.\|.LHDQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	720	LIGA.\|.AATA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	876	QLGE.\|.EHPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	977	CLEL.\|.LGHT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	979	ELGH.\|.HTGE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	1051	FPKA.\|.ASVP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)