Q92900: Regulator of nonsense transcripts 1
Protein names | - Regulator of nonsense transcripts 1 - 3.6.4.- - ATP-dependent helicase RENT1 - Nonsense mRNA reducing factor 1 - NORF1 - Up-frameshift suppressor 1 homolog - hUpf1 |
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Gene names | UPF1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q92900 |
5
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTPPGG PGGPGGGGAG
70 80 90 100 110 120
GPGGAGAGAA AGQLDAQVGP EGILQNGAVD DSVAKTSQLL AELNFEEDEE DTYYTKDLPI
130 140 150 160 170 180
HACSYCGIHD PACVVYCNTS KKWFCNGRGN TSGSHIVNHL VRAKCKEVTL HKDGPLGETV
190 200 210 220 230 240
LECYNCGCRN VFLLGFIPAK ADSVVVLLCR QPCASQSSLK DINWDSSQWQ PLIQDRCFLS
250 260 270 280 290 300
WLVKIPSEQE QLRARQITAQ QINKLEELWK ENPSATLEDL EKPGVDEEPQ HVLLRYEDAY
310 320 330 340 350 360
QYQNIFGPLV KLEADYDKKL KESQTQDNIT VRWDLGLNKK RIAYFTLPKT DSGNEDLVII
370 380 390 400 410 420
WLRDMRLMQG DEICLRYKGD LAPLWKGIGH VIKVPDNYGD EIAIELRSSV GAPVEVTHNF
430 440 450 460 470 480
QVDFVWKSTS FDRMQSALKT FAVDETSVSG YIYHKLLGHE VEDVIIKCQL PKRFTAQGLP
490 500 510 520 530 540
DLNHSQVYAV KTVLQRPLSL IQGPPGTGKT VTSATIVYHL ARQGNGPVLV CAPSNIAVDQ
550 560 570 580 590 600
LTEKIHQTGL KVVRLCAKSR EAIDSPVSFL ALHNQIRNMD SMPELQKLQQ LKDETGELSS
610 620 630 640 650 660
ADEKRYRALK RTAERELLMN ADVICCTCVG AGDPRLAKMQ FRSILIDEST QATEPECMVP
670 680 690 700 710 720
VVLGAKQLIL VGDHCQLGPV VMCKKAAKAG LSQSLFERLV VLGIRPIRLQ VQYRMHPALS
730 740 750 760 770 780
AFPSNIFYEG SLQNGVTAAD RVKKGFDFQW PQPDKPMFFY VTQGQEEIAS SGTSYLNRTE
790 800 810 820 830 840
AANVEKITTK LLKAGAKPDQ IGIITPYEGQ RSYLVQYMQF SGSLHTKLYQ EVEIASVDAF
850 860 870 880 890 900
QGREKDFIIL SCVRANEHQG IGFLNDPRRL NVALTRARYG VIIVGNPKAL SKQPLWNHLL
910 920 930 940 950 960
NYYKEQKVLV EGPLNNLRES LMQFSKPRKL VNTINPGARF MTTAMYDARE AIIPGSVYDR
970 980 990 1000 1010 1020
SSQGRPSSMY FQTHDQIGMI SAGPSHVAAM NIPIPFNLVM PPMPPPGYFG QANGPAAGRG
1030 1040 1050 1060 1070 1080
TPKGKTGRGG RQKNRFGLPG PSQTNLPNSQ ASQDVASQPF SQGALTQGYI SMSQPSQMSQ
1090 1100 1110 1120
PGLSQPELSQ DSYLGDEFKS QIDVALSQDS TYQGERAYQH GGVTGLSQY
Isoforms
- Isoform 2 of Regulator of nonsense transcripts 1Sequence View
10 20 30 40 50 60
MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTPPGG PGGPGGGGAG
70 80 90 100 110 120
GPGGAGAGAA AGQLDAQVGP EGILQNGAVD DSVAKTSQLL AELNFEEDEE DTYYTKDLPI
130 140 150 160 170 180
HACSYCGIHD PACVVYCNTS KKWFCNGRGN TSGSHIVNHL VRAKCKEVTL HKDGPLGETV
190 200 210 220 230 240
LECYNCGCRN VFLLGFIPAK ADSVVVLLCR QPCASQSSLK DINWDSSQWQ PLIQDRCFLS
250 260 270 280 290 300
WLVKIPSEQE QLRARQITAQ QINKLEELWK ENPSATLEDL EKPGVDEEPQ HVLLRYEDAY
310 320 330 340 350 360
QYQNIFGPLV KLEADYDKKL KESQTQDNIT VRWDLGLNKK RIAYFTLPKT DSGNEDLVII
370 380 390 400 410 420
WLRDMRLMQG DEICLRYKGD LAPLWKGIGH VIKVPDNYGD EIAIELRSSV GAPVEVTHNF
430 440 450 460 470 480
QVDFVWKSTS FDRMQSALKT FAVDETSVSG YIYHKLLGHE VEDVIIKCQL PKRFTAQGLP
490 500 510 520 530 540
DLNHSQVYAV KTVLQRPLSL IQGPPGTGKT VTSATIVYHL ARQGNGPVLV CAPSNIAVDQ
550 560 570 580 590 600
LTEKIHQTGL KVVRLCAKSR EAIDSPVSFL ALHNQIRNMD SMPELQKLQQ LKDETGELSS
610 620 630 640 650 660
ADEKRYRALK RTAERELLMN ADVICCTCVG AGDPRLAKMQ FRSILIDEST QATEPECMVP
670 680 690 700 710 720
VVLGAKQLIL VGDHCQLGPV VMCKKAAKAG LSQSLFERLV VLGIRPIRLQ VQYRMHPALS
730 740 750 760 770 780
AFPSNIFYEG SLQNGVTAAD RVKKGFDFQW PQPDKPMFFY VTQGQEEIAS SGTSYLNRTE
790 800 810 820 830 840
AANVEKITTK LLKAGAKPDQ IGIITPYEGQ RSYLVQYMQF SGSLHTKLYQ EVEIASVDAF
850 860 870 880 890 900
QGREKDFIIL SCVRANEHQG IGFLNDPRRL NVALTRARYG VIIVGNPKAL SKQPLWNHLL
910 920 930 940 950 960
NYYKEQKVLV EGPLNNLRES LMQFSKPRKL VNTINPGARF MTTAMYDARE AIIPGSVYDR
970 980 990 1000 1010 1020
SSQGRPSSMY FQTHDQIGMI SAGPSHVAAM NIPIPFNLVM PPMPPPGYFG QANGPAAGRG
1030 1040 1050 1060 1070 1080
TPKGKTGRGG RQKNRFGLPG PSQTNLPNSQ ASQDVASQPF SQGALTQGYI SMSQPSQMSQ
1090 1100 1110 1120
PGLSQPELSQ DSYLGDEFKS QIDVALSQDS TYQGERAYQH GGVTGLSQY
Protein Neighborhood
Domains & Features
5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q92900-1-unknown | MSVEAY... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q92900-1-unknown | MSVEAY... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt87281 | |||
Q92900-76- | AQVGPE... | 76 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q92900-76- | AQVGPE... | 76 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q92900-76-unknown | AQVGPE... | 76 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165137 | |||
Q92900-459-unknown | HEVEDV... | 459 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6634 | |||
Q92900-459-unknown | HEVEDV... | 459 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152772 | |||
Q92900-1055-unknown | VASQPF... | 1055 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13020 | |||
Q92900-1055-unknown | VASQPF... | 1055 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157259 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...HKLLGH | 458 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6634 | |||
...HKLLGH | 458 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136193 | |||
...QASQDV | 1054 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13020 | |||
...QASQDV | 1054 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140758 | |||
...GLSQY | 1129 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...GLSQY | 1129 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt82899 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 458 | LLGH.|.HEVE | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
GRAB_HUMAN | 1054 | SQDV.|.VASQ | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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