O60828: Polyglutamine-binding protein 1 {ECO:0000303|PubMed:10332029, ECO:0000303|PubMed:11163963}
Protein names | - Polyglutamine-binding protein 1 {ECO:0000303|PubMed:10332029, ECO:0000303|PubMed:11163963} - PQBP-1 {ECO:0000303|PubMed:10332029, ECO:0000303|PubMed:11163963} - 38 kDa nuclear protein containing a WW domain {ECO:0000303|PubMed:10198427} - Npw38 {ECO:0000303|PubMed:10198427} - Polyglutamine tract-binding protein 1 {ECO:0000303|PubMed:10332029} |
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Gene names | PQBP1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O60828 |
7
N-termini
4
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRLEGLPP SWYKVFDPSC
70 80 90 100 110 120
GLPYYWNADT DLVSWLSPHD PNSVVTKSAK KLRSSNADAE EKLDRSHDKS DRGHDKSDRS
130 140 150 160 170 180
HEKLDRGHDK SDRGHDKSDR DRERGYDKVD RERERDRERD RDRGYDKADR EEGKERRHHR
190 200 210 220 230 240
REELAPYPKS KKAVSRKDEE LDPMDPSSYS DAPRGTWSTG LPKRNEAKTG ADTTAAGPLF
250 260
QQRPYPSPGA VLRANAEASR TKQQD
Isoforms
- Isoform 2 of Polyglutamine-binding protein 1 - Isoform 3 of Polyglutamine-binding protein 1 - Isoform 4 of Polyglutamine-binding protein 1 - Isoform 5 of Polyglutamine-binding protein 1 - Isoform 6 of Polyglutamine-binding protein 1 - Isoform 7 of Polyglutamine-binding protein 1 - Isoform 8 of Polyglutamine-binding protein 1 - Isoform 9 of Polyglutamine-binding protein 1 - Isoform 10 of Polyglutamine-binding protein 1Sequence View
10 20 30 40 50 60
MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRLEGLPP SWYKVFDPSC
70 80 90 100 110 120
GLPYYWNADT DLVSWLSPHD PNSVVTKSAK KLRSSNADAE EKLDRSHDKS DRGHDKSDRS
130 140 150 160 170 180
HEKLDRGHDK SDRGHDKSDR DRERGYDKVD RERERDRERD RDRGYDKADR EEGKERRHHR
190 200 210 220 230 240
REELAPYPKS KKAVSRKDEE LDPMDPSSYS DAPRGTWSTG LPKRNEAKTG ADTTAAGPLF
250 260
QQRPYPSPGA VLRANAEASR TKQQD
10 20 30 40 50 60
MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRLEGLPP SWYKVFDPSC
70 80 90 100 110 120
GLPYYWNADT DLVSWLSPHD PNSVVTKSAK KLRSSNADAE EKLDRSHDKS DRGHDKSDRS
130 140 150 160 170 180
HEKLDRGHDK SDRGHDKSDR DRERGYDKVD RERERDRERD RDRGYDKADR EEGKERRHHR
190 200 210 220 230 240
REELAPYPKS KKAVSRKDEE LDPMDPSSYS DAPRGTWSTG LPKRNEAKTG ADTTAAGPLF
250 260
QQRPYPSPGA VLRANAEASR TKQQD
10 20 30 40 50 60
MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRLEGLPP SWYKVFDPSC
70 80 90 100 110 120
GLPYYWNADT DLVSWLSPHD PNSVVTKSAK KLRSSNADAE EKLDRSHDKS DRGHDKSDRS
130 140 150 160 170 180
HEKLDRGHDK SDRGHDKSDR DRERGYDKVD RERERDRERD RDRGYDKADR EEGKERRHHR
190 200 210 220 230 240
REELAPYPKS KKAVSRKDEE LDPMDPSSYS DAPRGTWSTG LPKRNEAKTG ADTTAAGPLF
250 260
QQRPYPSPGA VLRANAEASR TKQQD
10 20 30 40 50 60
MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRLEGLPP SWYKVFDPSC
70 80 90 100 110 120
GLPYYWNADT DLVSWLSPHD PNSVVTKSAK KLRSSNADAE EKLDRSHDKS DRGHDKSDRS
130 140 150 160 170 180
HEKLDRGHDK SDRGHDKSDR DRERGYDKVD RERERDRERD RDRGYDKADR EEGKERRHHR
190 200 210 220 230 240
REELAPYPKS KKAVSRKDEE LDPMDPSSYS DAPRGTWSTG LPKRNEAKTG ADTTAAGPLF
250 260
QQRPYPSPGA VLRANAEASR TKQQD
10 20 30 40 50 60
MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRLEGLPP SWYKVFDPSC
70 80 90 100 110 120
GLPYYWNADT DLVSWLSPHD PNSVVTKSAK KLRSSNADAE EKLDRSHDKS DRGHDKSDRS
130 140 150 160 170 180
HEKLDRGHDK SDRGHDKSDR DRERGYDKVD RERERDRERD RDRGYDKADR EEGKERRHHR
190 200 210 220 230 240
REELAPYPKS KKAVSRKDEE LDPMDPSSYS DAPRGTWSTG LPKRNEAKTG ADTTAAGPLF
250 260
QQRPYPSPGA VLRANAEASR TKQQD
10 20 30 40 50 60
MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRLEGLPP SWYKVFDPSC
70 80 90 100 110 120
GLPYYWNADT DLVSWLSPHD PNSVVTKSAK KLRSSNADAE EKLDRSHDKS DRGHDKSDRS
130 140 150 160 170 180
HEKLDRGHDK SDRGHDKSDR DRERGYDKVD RERERDRERD RDRGYDKADR EEGKERRHHR
190 200 210 220 230 240
REELAPYPKS KKAVSRKDEE LDPMDPSSYS DAPRGTWSTG LPKRNEAKTG ADTTAAGPLF
250 260
QQRPYPSPGA VLRANAEASR TKQQD
10 20 30 40 50 60
MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRLEGLPP SWYKVFDPSC
70 80 90 100 110 120
GLPYYWNADT DLVSWLSPHD PNSVVTKSAK KLRSSNADAE EKLDRSHDKS DRGHDKSDRS
130 140 150 160 170 180
HEKLDRGHDK SDRGHDKSDR DRERGYDKVD RERERDRERD RDRGYDKADR EEGKERRHHR
190 200 210 220 230 240
REELAPYPKS KKAVSRKDEE LDPMDPSSYS DAPRGTWSTG LPKRNEAKTG ADTTAAGPLF
250 260
QQRPYPSPGA VLRANAEASR TKQQD
10 20 30 40 50 60
MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRLEGLPP SWYKVFDPSC
70 80 90 100 110 120
GLPYYWNADT DLVSWLSPHD PNSVVTKSAK KLRSSNADAE EKLDRSHDKS DRGHDKSDRS
130 140 150 160 170 180
HEKLDRGHDK SDRGHDKSDR DRERGYDKVD RERERDRERD RDRGYDKADR EEGKERRHHR
190 200 210 220 230 240
REELAPYPKS KKAVSRKDEE LDPMDPSSYS DAPRGTWSTG LPKRNEAKTG ADTTAAGPLF
250 260
QQRPYPSPGA VLRANAEASR TKQQD
10 20 30 40 50 60
MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRLEGLPP SWYKVFDPSC
70 80 90 100 110 120
GLPYYWNADT DLVSWLSPHD PNSVVTKSAK KLRSSNADAE EKLDRSHDKS DRGHDKSDRS
130 140 150 160 170 180
HEKLDRGHDK SDRGHDKSDR DRERGYDKVD RERERDRERD RDRGYDKADR EEGKERRHHR
190 200 210 220 230 240
REELAPYPKS KKAVSRKDEE LDPMDPSSYS DAPRGTWSTG LPKRNEAKTG ADTTAAGPLF
250 260
QQRPYPSPGA VLRANAEASR TKQQD
Protein Neighborhood
Domains & Features
7 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O60828-1-unknown | MPLPVA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86043 | |||
O60828-1-unknown | MPLPVA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86044 | |||
O60828-1-unknown | MPLPVA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86045 | |||
O60828-1-unknown | MPLPVA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86046 | |||
O60828-1-unknown | MPLPVA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86047 | |||
O60828-1-unknown | MPLPVA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86048 | |||
O60828-1-unknown | MPLPVA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86049 | |||
O60828-1-unknown | MPLPVA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86050 | |||
O60828-2-unknown | PLPVAL... | 2 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O60828-2-unknown | PLPVAL... | 2 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | |||
O60828-2-unknown | PLPVAL... | 2 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | |||
O60828-2-unknown | PLPVAL... | 2 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110916 | |||
O60828-2-unknown | PLPVAL... | 2 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110917 | |||
O60828-2-unknown | PLPVAL... | 2 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110918 | |||
O60828-2-unknown | PLPVAL... | 2 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110919 | |||
O60828-2-unknown | PLPVAL... | 2 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110920 | |||
O60828-2-unknown | PLPVAL... | 2 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110921 | |||
O60828-2-unknown | PLPVAL... | 2 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110922 | |||
O60828-2-unknown | PLPVAL... | 2 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110923 | |||
O60828-32-unknown | DYDDDP... | 32 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10871 | |||
O60828-32-unknown | DYDDDP... | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137701 | |||
O60828-32-unknown | DYDDDP... | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137702 | |||
O60828-32-unknown | DYDDDP... | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137703 | |||
O60828-32-unknown | DYDDDP... | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137704 | |||
O60828-32-unknown | DYDDDP... | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137705 | |||
O60828-32-unknown | DYDDDP... | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137706 | |||
O60828-32-unknown | DYDDDP... | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137707 | |||
O60828-32-unknown | DYDDDP... | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137708 | |||
O60828-33-unknown | YDDDPV... | 33 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10881 | |||
O60828-33-unknown | YDDDPV... | 33 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137804 | |||
O60828-33-unknown | YDDDPV... | 33 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137805 | |||
O60828-33-unknown | YDDDPV... | 33 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137806 | |||
O60828-33-unknown | YDDDPV... | 33 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137807 | |||
O60828-33-unknown | YDDDPV... | 33 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137808 | |||
O60828-33-unknown | YDDDPV... | 33 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137811 | |||
O60828-33-unknown | YDDDPV... | 33 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137813 | |||
O60828-33-unknown | YDDDPV... | 33 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137814 | |||
O60828-77-unknown | SPHDPN... | 77 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5209 | |||
O60828-77-unknown | SPHDPN... | 77 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7050 | |||
O60828-77-unknown | SPHDPN... | 77 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141112 | |||
O60828-77-unknown | SPHDPN... | 77 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141113 | |||
O60828-77-unknown | SPHDPN... | 77 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141114 | |||
O60828-77-unknown | SPHDPN... | 77 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141115 | |||
O60828-77-unknown | SPHDPN... | 77 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141118 | |||
O60828-197-unknown | KDEELD... | 197 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169924 | |||
O60828-197-unknown | KDEELD... | 197 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169925 | |||
O60828-197-unknown | KDEELD... | 197 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169926 | |||
O60828-197- | KDEELD... | 197 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...EIIAED | 31 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10871 | |||
...EIIAED | 31 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120700 | |||
...EIIAED | 31 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120701 | |||
...EIIAED | 31 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120702 | |||
...EIIAED | 31 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120703 | |||
...EIIAED | 31 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120704 | |||
...EIIAED | 31 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120705 | |||
...EIIAED | 31 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120706 | |||
...EIIAED | 31 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120707 | |||
...IIAEDY | 32 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10881 | |||
...IIAEDY | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120805 | |||
...IIAEDY | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120806 | |||
...IIAEDY | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120807 | |||
...IIAEDY | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120808 | |||
...IIAEDY | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120809 | |||
...IIAEDY | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120812 | |||
...IIAEDY | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120814 | |||
...IIAEDY | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120815 | |||
...LVSWLS | 76 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5209 | |||
...LVSWLS | 76 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7050 | |||
...LVSWLS | 76 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124266 | |||
...LVSWLS | 76 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124267 | |||
...LVSWLS | 76 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124268 | |||
...LVSWLS | 76 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124269 | |||
...LVSWLS | 76 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124272 | |||
...TKQQD | 265 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...TKQQD | 265 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt81664 | |||
...TKQQD | 265 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt81663 | |||
...TKQQD | 265 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt81661 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 31 | IAED.|.DYDD | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAB_HUMAN | 32 | AEDY.|.YDDD | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
CATL1_HUMAN | 76 | SWLS.|.SPHD | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
CATS_HUMAN | 76 | SWLS.|.SPHD | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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