Q04724: Transducin-like enhancer protein 1

General Information

Protein names	- Transducin-like enhancer protein 1 - E(Sp1) homolog - Enhancer of split groucho-like protein 1 - ESG1
Gene names	TLE1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q04724

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH
        70         80         90        100        110        120
YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN
       130        140        150        160        170        180
AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SAGLLALSSA LSGQSHLAIK
       190        200        210        220        230        240
DDKKHHDAEH HRDREPGTSN SLLVPDSLRG TDKRRNGPEF SNDIKKRKVD DKDSSHYDSD
       250        260        270        280        290        300
GDKSDDNLVV DVSNEDPSSP RASPAHSPRE NGIDKNRLLK KDASSSPAST ASSASSTSLK
       310        320        330        340        350        360
SKEMSLHEKA STPVLKSSTP TPRSDMPTPG TSATPGLRPG LGKPPAIDPL VNQAAAGLRT
       370        380        390        400        410        420
PLAVPGPYPA PFGMVPHAGM NGELTSPGAA YASLHNMSPQ MSAAAAAAAV VAYGRSPMVG
       430        440        450        460        470        480
FDPPPHMRVP TIPPNLAGIP GGKPAYSFHV TADGQMQPVP FPPDALIGPG IPRHARQINT
       490        500        510        520        530        540
LNHGEVVCAV TISNPTRHVY TGGKGCVKVW DISHPGNKSP VSQLDCLNRD NYIRSCKLLP
       550        560        570        580        590        600
DGCTLIVGGE ASTLSIWDLA APTPRIKAEL TSSAPACYAL AISPDSKVCF SCCSDGNIAV
       610        620        630        640        650        660
WDLHNQTLVR QFQGHTDGAS CIDISNDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI
       670        680        690        700        710        720
FSLGYCPTGE WLAVGMESSN VEVLHVNKPD KYQLHLHESC VLSLKFAYCG KWFVSTGKDN
       730        740        750        760        770
LLNAWRTPYG ASIFQSKESS SVLSCDISVD DKYIVTGSGD KKATVYEVIY

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
Q04724-1-unknown	MFPQSR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q04724-57-unknown	MQRHYV...	57	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000365646
Q04724-173-unknown	GQSHLA...	173	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7728
Q04724-173-unknown	GQSHLA...	173	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6233
Q04724-326-unknown	MPTPGT...	326	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000365667
Q04724-326-unknown	MPTPGT...	326	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000365655
Q04724-401-	MSAAAA...	401		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SSALSG	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7728
...SSALSG	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6233
...KVDDKD	232	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391347
...YEVIY	770	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	172	ALSG.\|.GQSH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	172	ALSG.\|.GQSH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)