Q7L014: Probable ATP-dependent RNA helicase DDX46
Protein names | - Probable ATP-dependent RNA helicase DDX46 - 3.6.4.13 - DEAD box protein 46 - PRP5 homolog |
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Gene names | DDX46 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q7L014 |
18
N-termini
5
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MGRESRHYRK RSASRGRSGS RSRSRSPSDK RSKRGDDRRS RSRDRDRRRE RSRSRDKRRS
70 80 90 100 110 120
RSRDRKRLRR SRSRERDRSR ERRRSRSRDR RRSRSRSRGR RSRSSSPGNK SKKTENRSRS
130 140 150 160 170 180
KEKTDGGESS KEKKKDKDDK EDEKEKDAGN FDQNKLEEEM RKRKERVEKW REEQRKKAME
190 200 210 220 230 240
NIGELKKEIE EMKQGKKWSL EDDDDDEDDP AEAEKEGNEM EGEELDPLDA YMEEVKEEVK
250 260 270 280 290 300
KFNMRSVKGG GGNEKKSGPT VTKVVTVVTT KKAVVDSDKK KGELMENDQD AMEYSSEEEE
310 320 330 340 350 360
VDLQTALTGY QTKQRKLLEP VDHGKIEYEP FRKNFYVEVP ELAKMSQEEV NVFRLEMEGI
370 380 390 400 410 420
TVKGKGCPKP IKSWVQCGIS MKILNSLKKH GYEKPTPIQT QAIPAIMSGR DLIGIAKTGS
430 440 450 460 470 480
GKTIAFLLPM FRHIMDQRSL EEGEGPIAVI MTPTRELALQ ITKECKKFSK TLGLRVVCVY
490 500 510 520 530 540
GGTGISEQIA ELKRGAEIIV CTPGRMIDML AANSGRVTNL RRVTYVVLDE ADRMFDMGFE
550 560 570 580 590 600
PQVMRIVDNV RPDRQTVMFS ATFPRAMEAL ARRILSKPIE VQVGGRSVVC SDVEQQVIVI
610 620 630 640 650 660
EEEKKFLKLL ELLGHYQESG SVIIFVDKQE HADGLLKDLM RASYPCMSLH GGIDQYDRDS
670 680 690 700 710 720
IINDFKNGTC KLLVATSVAA RGLDVKHLIL VVNYSCPNHY EDYVHRAGRT GRAGNKGYAY
730 740 750 760 770 780
TFITEDQARY AGDIIKALEL SGTAVPPDLE KLWSDFKDQQ KAEGKIIKKS SGFSGKGFKF
790 800 810 820 830 840
DETEQALANE RKKLQKAALG LQDSDDEDAA VDIDEQIESM FNSKKRVKDM AAPGTSSVPA
850 860 870 880 890 900
PTAGNAEKLE IAKRLALRIN AQKNLGIESQ DVMQQATNAI LRGGTILAPT VSAKTIAEQL
910 920 930 940 950 960
AEKINAKLNY VPLEKQEEER QDGGQNESFK RYEEELEIND FPQTARWKVT SKEALQRISE
970 980 990 1000 1010 1020
YSEAAITIRG TYFPPGKEPK EGERKIYLAI ESANELAVQK AKAEITRLIK EELIRLQNSY
1030
QPTNKGRYKV L
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
18 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q7L014-1-unknown | MGRESR... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q7L014-229-unknown | DAYMEE... | 229 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14657 | |||
Q7L014-264-unknown | VVTVVT... | 264 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q7L014-303- | LQTALT... | 303 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q7L014-303- | LQTALT... | 303 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q7L014-334- | NFYVEV... | 334 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q7L014-334- | NFYVEV... | 334 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q7L014-335- | FYVEVP... | 335 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q7L014-403- | IPAIMS... | 403 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q7L014-797- | AALGLQ... | 797 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q7L014-804-unknown | SDDEDA... | 804 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12666 | |||
Q7L014-815-unknown | EQIESM... | 815 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12667 | |||
Q7L014-835-unknown | TSSVPA... | 835 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q7L014-837- | SVPAPT... | 837 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q7L014-837- | SVPAPT... | 837 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q7L014-872- | VMQQAT... | 872 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q7L014-872- | VMQQAT... | 872 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q7L014-872- | VMQQAT... | 872 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q7L014-872- | VMQQAT... | 872 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q7L014-872- | VMQQAT... | 872 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q7L014-872- | VMQQAT... | 872 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q7L014-872- | VMQQAT... | 872 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q7L014-872- | VMQQAT... | 872 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q7L014-872-unknown | VMQQAT... | 872 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q7L014-904- | INAKLN... | 904 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q7L014-923-unknown | GGQNES... | 923 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q7L014-923- | GGQNES... | 923 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q7L014-923- | GGQNES... | 923 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q7L014-992-unknown | SANELA... | 992 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6562 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...ELDPLD | 228 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14657 | |||
...LGLQDS | 803 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12666 | |||
...AVDIDE | 814 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12667 | |||
...YLAIES | 991 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6562 | |||
...RYKVL | 1031 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAM_HUMAN | 228 | DPLD.|.DAYM | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
GRAB_HUMAN | 803 | LQDS.|.SDDE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
GRAB_HUMAN | 814 | DIDE.|.EQIE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
CATL1_HUMAN | 991 | AIES.|.SANE | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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