O75475: PC4 and SFRS1-interacting protein

General Information

Protein names	- PC4 and SFRS1-interacting protein - CLL-associated antigen KW-7 - Dense fine speckles 70 kDa protein - DFS 70 - Lens epithelium-derived growth factor - Transcriptional coactivator p75/p52
Gene names	PSIP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75475

11 N-termini

8 C-termini

9 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of PC4 and SFRS1-interacting protein - Isoform 3 of PC4 and SFRS1-interacting protein

Sequence View

        10         20         30         40         50         60
MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET AFLGPKDIFP
        70         80         90        100        110        120
YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQAATK QSNASSDVEV EEKETSVSKE
       130        140        150        160        170        180
DTDHEEKASN EDVTKAVDIT TPKAARRGRK RKAEKQVETE EAGVVTTATA SVNLKVSPKR
       190        200        210        220        230        240
GRPAATEVKI PKPRGRPKMV KQPCPSESDI ITEEDKSKKK GQEEKQPKKQ PKKDEEGQKE
       250        260        270        280        290        300
EDKPRKEPDK KEGKKEVESK RKNLAKTGVT STSDSEEEGD DQEGEKKRKG GRNFQTAHRR
       310        320        330        340        350        360
NMLKGQHEKE AADRKRKQEE QMETEQQNKD EGKKPEVKKV EKKRETSMDS RLQRIHAEIK
       370        380        390        400        410        420
NSLKIDNLDV NRCIEALDEL ASLQVTMQQA QKHTEMITTL KKIRRFKVSQ VIMEKSTMLY
       430        440        450        460        470        480
NKFKNMFLVG EGDSVITQVL NKSLAEQRQH EEANKTKDQG KKGPNKKLEK EQTGSKTLNG
       490        500        510        520        530
GSDAQDGNQP QHNGESNEDS KDNHEASTKK KPSSEERETE ISLKDSTLDN         10         20         30         40         50         60
MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET AFLGPKDIFP
        70         80         90        100        110        120
YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQAATK QSNASSDVEV EEKETSVSKE
       130        140        150        160        170        180
DTDHEEKASN EDVTKAVDIT TPKAARRGRK RKAEKQVETE EAGVVTTATA SVNLKVSPKR
       190        200        210        220        230        240
GRPAATEVKI PKPRGRPKMV KQPCPSESDI ITEEDKSKKK GQEEKQPKKQ PKKDEEGQKE
       250        260        270        280        290        300
EDKPRKEPDK KEGKKEVESK RKNLAKTGVT STSDSEEEGD DQEGEKKRKG GRNFQTAHRR
       310        320        330        340        350        360
NMLKGQHEKE AADRKRKQEE QMETEQQNKD EGKKPEVKKV EKKRETSMDS RLQRIHAEIK
       370        380        390        400        410        420
NSLKIDNLDV NRCIEALDEL ASLQVTMQQA QKHTEMITTL KKIRRFKVSQ VIMEKSTMLY
       430        440        450        460        470        480
NKFKNMFLVG EGDSVITQVL NKSLAEQRQH EEANKTKDQG KKGPNKKLEK EQTGSKTLNG
       490        500        510        520        530
GSDAQDGNQP QHNGESNEDS KDNHEASTKK KPSSEERETE ISLKDSTLDN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 8 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75475-1-unknown	MTRDFK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75475-1-unknown	MTRDFK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86389
O75475-1-unknown	MTRDFK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86390
O75475-25-unknown	VDEVPD...	25	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169965
O75475-25-unknown	VDEVPD...	25	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169966
O75475-25-	VDEVPD...	25		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O75475-31-unknown	GAVKPP...	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1487
O75475-31-unknown	GAVKPP...	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2777
O75475-31-unknown	GAVKPP...	31	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137650
O75475-31-unknown	GAVKPP...	31	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137652
O75475-31-	GAVKPP...	31		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75475-31-	GAVKPP...	31		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75475-47-unknown	THETAF...	47	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5252
O75475-47-unknown	THETAF...	47	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138902
O75475-47-unknown	THETAF...	47	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138903
O75475-81-unknown	LWEIDN...	81	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16966
O75475-81-unknown	LWEIDN...	81	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141348
O75475-81-unknown	LWEIDN...	81	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141349
O75475-86-unknown	NNPKVK...	86	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1490
O75475-86-unknown	NNPKVK...	86	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2780
O75475-86-unknown	NNPKVK...	86	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141650
O75475-86-unknown	NNPKVK...	86	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141652
O75475-304-unknown	KGQHEK...	304	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13834
O75475-304-unknown	KGQHEK...	304	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149967
O75475-304-unknown	KGQHEK...	304	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149968
O75475-434-	SVITQV...	434		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O75475-434-	SVITQV...	434		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75475-434-	SVITQV...	434		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75475-487-unknown	GNQPQH...	487	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1493
O75475-487-unknown	GNQPQH...	487	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2783

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...DEVPDG	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1487
...DEVPDG	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2777
...DEVPDG	30	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120646
...DEVPDG	30	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120648
...IFFFGT	46	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5252
...IFFFGT	46	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt121967
...IFFFGT	46	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt121968
...GFNEGL	80	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16966
...GFNEGL	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124516
...GFNEGL	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124517
...LWEIDN	85	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1490
...LWEIDN	85	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2780
...LWEIDN	85	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124830
...LWEIDN	85	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124832
...RRNMLK	303	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13834
...RRNMLK	303	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133359
...RRNMLK	303	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133360
...SDAQDG	486	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1493
...SDAQDG	486	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2783
...STLDN	530		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...STLDN	530	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...STLDN	530		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	30	VPDG.\|.GAVK	inferred from experiment	unknown	MEROPS	Casiano CA	Wu X et al.:Caspase cleavage of the nuclear... (C14.003)	12181742,
CASP7_HUMAN	30	VPDG.\|.GAVK	inferred from experiment	unknown	MEROPS	Casiano CA	Wu X et al.:Caspase cleavage of the nuclear... (C14.003)	12181742,
CATL1_HUMAN	46	FFGT.\|.THET	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	80	NEGL.\|.LWEI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP3_HUMAN	85	EIDN.\|.NNPK	inferred from experiment	unknown	MEROPS	Casiano CA	Wu X et al.:Caspase cleavage of the nuclear... (C14.003)	12181742,
CASP7_HUMAN	85	EIDN.\|.NNPK	inferred from experiment	unknown	MEROPS	Casiano CA	Wu X et al.:Caspase cleavage of the nuclear... (C14.003)	12181742,
GRAM_HUMAN	303	NMLK.\|.KGQH	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP3_HUMAN	486	AQDG.\|.GNQP	inferred from experiment	unknown	MEROPS	Casiano CA	Wu X et al.:Caspase cleavage of the nuclear... (C14.003)	12181742,
CASP7_HUMAN	486	AQDG.\|.GNQP	inferred from experiment	unknown	MEROPS	Casiano CA	Wu X et al.:Caspase cleavage of the nuclear... (C14.003)	12181742,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)