P17844: Probable ATP-dependent RNA helicase DDX5

General Information

Protein names	- Probable ATP-dependent RNA helicase DDX5 - 3.6.4.13 - DEAD box protein 5 - RNA helicase p68
Gene names	DDX5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P17844

7 N-termini

16 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGYSSDRDR GRDRGFGAPR FGGSRAGPLS GKKFGNPGEK LVKKKWNLDE LPKFEKNFYQ
        70         80         90        100        110        120
EHPDLARRTA QEVETYRRSK EITVRGHNCP KPVLNFYEAN FPANVMDVIA RQNFTEPTAI
       130        140        150        160        170        180
QAQGWPVALS GLDMVGVAQT GSGKTLSYLL PAIVHINHQP FLERGDGPIC LVLAPTRELA
       190        200        210        220        230        240
QQVQQVAAEY CRACRLKSTC IYGGAPKGPQ IRDLERGVEI CIATPGRLID FLECGKTNLR
       250        260        270        280        290        300
RTTYLVLDEA DRMLDMGFEP QIRKIVDQIR PDRQTLMWSA TWPKEVRQLA EDFLKDYIHI
       310        320        330        340        350        360
NIGALELSAN HNILQIVDVC HDVEKDEKLI RLMEEIMSEK ENKTIVFVET KRRCDELTRK
       370        380        390        400        410        420
MRRDGWPAMG IHGDKSQQER DWVLNEFKHG KAPILIATDV ASRGLDVEDV KFVINYDYPN
       430        440        450        460        470        480
SSEDYIHRIG RTARSTKTGT AYTFFTPNNI KQVSDLISVL REANQAINPK LLQLVEDRGS
       490        500        510        520        530        540
GRSRGRGGMK DDRRDRYSAG KRGGFNTFRD RENYDRGYSS LLKRDFGAKT QNGVYSAANY
       550        560        570        580        590        600
TNGSFGSNFV SAGIQTSFRT GNPTGTYQNG YDSTQQYGSN VPNMHNGMNQ QAYAYPATAA
       610
APMIGYPMPT GYSQ

Isoforms

- Isoform 2 of Probable ATP-dependent RNA helicase DDX5

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 16 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P17844-1-unknown	MSGYSS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P17844-58-	FYQEHP...	58			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P17844-58-	FYQEHP...	58			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P17844-60-unknown	QEHPDL...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5628
P17844-106-unknown	MDVIAR...	106		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464256
P17844-106-unknown	MDVIAR...	106		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000462513
P17844-106-unknown	MDVIAR...	106		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464304
P17844-106-unknown	MDVIAR...	106		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464064
P17844-106-unknown	MDVIAR...	106		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463541
P17844-106-unknown	MDVIAR...	106		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463101
P17844-106-unknown	MDVIAR...	106		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464587
P17844-163-unknown	ERGDGP...	163		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000462222
P17844-242-acetylation	TTYLVL...	242	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P17844-323-unknown	VEKDEK...	323		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11266

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KLVKKK	44	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463168
...EKNFYQ	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5628
...RRTAQE	71	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462587
...SKEITV	83	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462093
...NCPKPV	92	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462596
...EPTAIQ	120	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462206
...LDMVGV	136	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462513
...LDMVGV	136	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464587
...QTGSGK	143	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464256
...QTGSGK	143	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463101
...SYLLPA	151	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463541
...IVHINH	157	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464064
...DGPICL	170	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464304
...GPQIRD	212	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464337
...IVDQIR	269	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463923
...DVCHDV	322	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11266
...EKDEKL	328	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462222
...TGYSQ	614	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	59	NFYQ.\|.QEHP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	322	CHDV.\|.VEKD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)