Q96C36: Pyrroline-5-carboxylate reductase 2

General Information

Protein names	- Pyrroline-5-carboxylate reductase 2 - P5C reductase 2 - P5CR 2 - 1.5.1.2
Gene names	PYCR2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96C36

4 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSVGFIGAGQ LAYALARGFT AAGILSAHKI IASSPEMNLP TVSALRKMGV NLTRSNKETV
        70         80         90        100        110        120
KHSDVLFLAV KPHIIPFILD EIGADVQARH IVVSCAAGVT ISSVEKKLMA FQPAPKVIRC
       130        140        150        160        170        180
MTNTPVVVQE GATVYATGTH ALVEDGQLLE QLMSSVGFCT EVEEDLIDAV TGLSGSGPAY
       190        200        210        220        230        240
AFMALDALAD GGVKMGLPRR LAIQLGAQAL LGAAKMLLDS EQHPCQLKDN VCSPGGATIH
       250        260        270        280        290        300
ALHFLESGGF RSLLINAVEA SCIRTRELQS MADQEKISPA ALKKTLLDRV KLESPTVSTL
       310        320
TPSSPGKLLT RSLALGGKKD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96C36-2-unknown	MSVGFI...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96C36-2-Acetylation	SVGFIG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96C36-2-Acetylation	SVGFIG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q96C36-2-Acetylation	SVGFIG...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q96C36-219-unknown	DSEQHP...	219		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8008
Q96C36-220-unknown	SEQHPC...	220		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6660
Q96C36-220-unknown	SEQHPC...	220		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8009

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...AKMLLD	218	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8008
...KMLLDS	219	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6660
...KMLLDS	219	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8009
...GGKKD	320	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GGKKD	320		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...GGKKD	320		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...GGKKD	320		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...GGKKD	320		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	218	MLLD.\|.DSEQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	219	LLDS.\|.SEQH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	219	LLDS.\|.SEQH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)