TopFIND 4.0

Q9C0C9: (E3-independent) E2 ubiquitin-conjugating enzyme

General Information

Protein names
- (E3-independent) E2 ubiquitin-conjugating enzyme
- 2.3.2.24 {ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}
- E2/E3 hybrid ubiquitin-protein ligase UBE2O
- Ubiquitin carrier protein O
- Ubiquitin-conjugating enzyme E2 O
- Ubiquitin-conjugating enzyme E2 of 230 kDa
- Ubiquitin-conjugating enzyme E2-230K
- Ubiquitin-protein ligase O
Gene names UBE2O
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9C0C9

15

N-termini

7

C-termini

5

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MADPAAPTPA APAPAQAPAP APEAVPAPAA APVPAPAPAS DSASGPSSDS GPEAGSQRLL 
        70         80         90        100        110        120 
FSHDLVSGRY RGSVHFGLVR LIHGEDSDSE GEEEGRGSSG CSEAGGAGHE EGRASPLRRG 
       130        140        150        160        170        180 
YVRVQWYPEG VKQHVKETKL KLEDRSVVPR DVVRHMRSTD SQCGTVIDVN IDCAVKLIGT 
       190        200        210        220        230        240 
NCIIYPVNSK DLQHIWPFMY GDYIAYDCWL GKVYDLKNQI ILKLSNGARC SMNTEDGAKL 
       250        260        270        280        290        300 
YDVCPHVSDS GLFFDDSYGF YPGQVLIGPA KIFSSVQWLS GVKPVLSTKS KFRVVVEEVQ 
       310        320        330        340        350        360 
VVELKVTWIT KSFCPGGTDS VSPPPSVITQ ENLGRVKRLG CFDHAQRQLG ERCLYVFPAK 
       370        380        390        400        410        420 
VEPAKIAWEC PEKNCAQGEG SMAKKVKRLL KKQVVRIMSC SPDTQCSRDH SMEDPDKKGE 
       430        440        450        460        470        480 
SKTKSEAESA SPEETPDGSA SPVEMQDEGA EEPHEAGEQL PPFLLKEGRD DRLHSAEQDA 
       490        500        510        520        530        540 
DDEAADDTDD TSSVTSSASS TTSSQSGSGT SRKKSIPLSI KNLKRKHKRK KNKITRDFKP 
       550        560        570        580        590        600 
GDRVAVEVVT TMTSADVMWQ DGSVECNIRS NDLFPVHHLD NNEFCPGDFV VDKRVQSCPD 
       610        620        630        640        650        660 
PAVYGVVQSG DHIGRTCMVK WFKLRPSGDD VELIGEEEDV SVYDIADHPD FRFRTTDIVI 
       670        680        690        700        710        720 
RIGNTEDGAP HKEDEPSVGQ VARVDVSSKV EVVWADNSKT IILPQHLYNI ESEIEESDYD 
       730        740        750        760        770        780 
SVEGSTSGAS SDEWEDDSDS WETDNGLVED EHPKIEEPPI PPLEQPVAPE DKGVVISEEA 
       790        800        810        820        830        840 
ATAAVQGAVA MAAPMAGLME KAGKDGPPKS FRELKEAIKI LESLKNMTVE QLLTGSPTSP 
       850        860        870        880        890        900 
TVEPEKPTRE KKFLDDIKKL QENLKKTLDN VAIVEEEKME AVPDVERKED KPEGQSPVKA 
       910        920        930        940        950        960 
EWPSETPVLC QQCGGKPGVT FTSAKGEVFS VLEFAPSNHS FKKIEFQPPE AKKFFSTVRK 
       970        980        990       1000       1010       1020 
EMALLATSLP EGIMVKTFED RMDLFSALIK GPTRTPYEDG LYLFDIQLPN IYPAVPPHFC 
      1030       1040       1050       1060       1070       1080 
YLSQCSGRLN PNLYDNGKVC VSLLGTWIGK GTERWTSKSS LLQVLISIQG LILVNEPYYN 
      1090       1100       1110       1120       1130       1140 
EAGFDSDRGL QEGYENSRCY NEMALIRVVQ SMTQLVRRPP EVFEQEIRQH FSTGGWRLVN 
      1150       1160       1170       1180       1190       1200 
RIESWLETHA LLEKAQALPN GVPKASSSPE PPAVAELSDS GQQEPEDGGP APGEASQGSD 
      1210       1220       1230       1240       1250       1260 
SEGGAQGLAS ASRDHTDQTS ETAPDASVPP SVKPKKRRKS YRSFLPEKSG YPDIGFPLFP 
      1270       1280       1290    
LSKGFIKSIR GVLTQFRAAL LEAGMPECTE DK

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

15 N-termini - 7 C-termini - 5 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)