P55884: Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001}
Protein names | - Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001} - eIF3b {ECO:0000255|HAMAP-Rule:MF_03001} - Eukaryotic translation initiation factor 3 subunit 9 {ECO:0000255|HAMAP-Rule:MF_03001} - Prt1 homolog - hPrt1 - eIF-3-eta {ECO:0000255|HAMAP-Rule:MF_03001} - eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03001} - eIF3 p116 |
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Gene names | EIF3B |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P55884 |
20
N-termini
4
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MQDAENVAVP EAAEERAEPG QQQPAAEPPP AEGLLRPAGP GAPEAAGTEA SSEEVGIAEA
70 80 90 100 110 120
GPESEVRTEP AAEAEAASGP SESPSPPAAE ELPGSHAEPP VPAQGEAPGE QARDERSDSR
130 140 150 160 170 180
AQAVSEDAGG NEGRAAEAEP RALENGDADE PSFSDPEDFV DDVSEEELLG DVLKDRPQEA
190 200 210 220 230 240
DGIDSVIVVD NVPQVGPDRL EKLKNVIHKI FSKFGKITND FYPEEDGKTK GYIFLEYASP
250 260 270 280 290 300
AHAVDAVKNA DGYKLDKQHT FRVNLFTDFD KYMTISDEWD IPEKQPFKDL GNLRYWLEEA
310 320 330 340 350 360
ECRDQYSVIF ESGDRTSIFW NDVKDPVSIE ERARWTETYV RWSPKGTYLA TFHQRGIALW
370 380 390 400 410 420
GGEKFKQIQR FSHQGVQLID FSPCERYLVT FSPLMDTQDD PQAIIIWDIL TGHKKRGFHC
430 440 450 460 470 480
ESSAHWPIFK WSHDGKFFAR MTLDTLSIYE TPSMGLLDKK SLKISGIKDF SWSPGGNIIA
490 500 510 520 530 540
FWVPEDKDIP ARVTLMQLPT RQEIRVRNLF NVVDCKLHWQ KNGDYLCVKV DRTPKGTQGV
550 560 570 580 590 600
VTNFEIFRMR EKQVPVDVVE MKETIIAFAW EPNGSKFAVL HGEAPRISVS FYHVKNNGKI
610 620 630 640 650 660
ELIKMFDKQQ ANTIFWSPQG QFVVLAGLRS MNGALAFVDT SDCTVMNIAE HYMASDVEWD
670 680 690 700 710 720
PTGRYVVTSV SWWSHKVDNA YWLWTFQGRL LQKNNKDRFC QLLWRPRPPT LLSQEQIKQI
730 740 750 760 770 780
KKDLKKYSKI FEQKDRLSQS KASKELVERR RTMMEDFRKY RKMAQELYME QKNERLELRG
790 800 810
GVDTDELDSN VDDWEEETIE FFVTEEIIPL GNQE
Isoforms
- Isoform 2 of Eukaryotic translation initiation factor 3 subunit BSequence View
10 20 30 40 50 60
MQDAENVAVP EAAEERAEPG QQQPAAEPPP AEGLLRPAGP GAPEAAGTEA SSEEVGIAEA
70 80 90 100 110 120
GPESEVRTEP AAEAEAASGP SESPSPPAAE ELPGSHAEPP VPAQGEAPGE QARDERSDSR
130 140 150 160 170 180
AQAVSEDAGG NEGRAAEAEP RALENGDADE PSFSDPEDFV DDVSEEELLG DVLKDRPQEA
190 200 210 220 230 240
DGIDSVIVVD NVPQVGPDRL EKLKNVIHKI FSKFGKITND FYPEEDGKTK GYIFLEYASP
250 260 270 280 290 300
AHAVDAVKNA DGYKLDKQHT FRVNLFTDFD KYMTISDEWD IPEKQPFKDL GNLRYWLEEA
310 320 330 340 350 360
ECRDQYSVIF ESGDRTSIFW NDVKDPVSIE ERARWTETYV RWSPKGTYLA TFHQRGIALW
370 380 390 400 410 420
GGEKFKQIQR FSHQGVQLID FSPCERYLVT FSPLMDTQDD PQAIIIWDIL TGHKKRGFHC
430 440 450 460 470 480
ESSAHWPIFK WSHDGKFFAR MTLDTLSIYE TPSMGLLDKK SLKISGIKDF SWSPGGNIIA
490 500 510 520 530 540
FWVPEDKDIP ARVTLMQLPT RQEIRVRNLF NVVDCKLHWQ KNGDYLCVKV DRTPKGTQGV
550 560 570 580 590 600
VTNFEIFRMR EKQVPVDVVE MKETIIAFAW EPNGSKFAVL HGEAPRISVS FYHVKNNGKI
610 620 630 640 650 660
ELIKMFDKQQ ANTIFWSPQG QFVVLAGLRS MNGALAFVDT SDCTVMNIAE HYMASDVEWD
670 680 690 700 710 720
PTGRYVVTSV SWWSHKVDNA YWLWTFQGRL LQKNNKDRFC QLLWRPRPPT LLSQEQIKQI
730 740 750 760 770 780
KKDLKKYSKI FEQKDRLSQS KASKELVERR RTMMEDFRKY RKMAQELYME QKNERLELRG
790 800 810
GVDTDELDSN VDDWEEETIE FFVTEEIIPL GNQE
Protein Neighborhood
Domains & Features
20 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P55884-1-unknown | MQDAEN... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73767 | |||
P55884-1- | MQDAEN... | 1 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
P55884-1- | MQDAEN... | 1 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
P55884-1- | MQDAEN... | 1 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P55884-1-Acetylation | MQDAEN... | 1 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P55884-1-Acetylation | MQDAEN... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
P55884-1-Acetylation | MQDAEN... | 1 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
P55884-1-Acetylation | MQDAEN... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
P55884-1-Acetylation | MQDAEN... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt105481 | ||
P55884-4-unknown | AENVAV... | 4 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169453 | |||
P55884-4- | AENVAV... | 4 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
P55884-4- | AENVAV... | 4 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P55884-4- | AENVAV... | 4 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P55884-7- | VAVPEA... | 7 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P55884-7- | VAVPEA... | 7 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P55884-7- | VAVPEA... | 7 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_CD95 | 23264352 | |||
P55884-7- | VAVPEA... | 7 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P55884-7- | VAVPEA... | 7 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P55884-7- | VAVPEA... | 7 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P55884-7- | VAVPEA... | 7 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P55884-7-unknown | VAVPEA... | 7 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P55884-7-unknown | VAVPEA... | 7 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P55884-7-unknown | VAVPEA... | 7 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159619 | |||
P55884-8- | AVPEAA... | 8 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_CD95 | 23264352 | |||
P55884-8- | AVPEAA... | 8 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P55884-8- | AVPEAA... | 8 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
P55884-8- | AVPEAA... | 8 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
P55884-8- | AVPEAA... | 8 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P55884-8- | AVPEAA... | 8 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P55884-8- | AVPEAA... | 8 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P55884-8- | AVPEAA... | 8 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P55884-8-unknown | AVPEAA... | 8 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P55884-8-unknown | AVPEAA... | 8 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161502 | |||
P55884-36-unknown | RPAGPG... | 36 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6052 | |||
P55884-36-unknown | RPAGPG... | 36 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt138060 | |||
P55884-76- | AASGPS... | 76 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P55884-76-unknown | AASGPS... | 76 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175214 | |||
P55884-121-unknown | AQAVSE... | 121 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10107 | |||
P55884-121-unknown | AQAVSE... | 121 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143521 | |||
P55884-123- | AVSEDA... | 123 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P55884-123-unknown | AVSEDA... | 123 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173336 | |||
P55884-185-unknown | SVIVVD... | 185 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170577 | |||
P55884-185- | SVIVVD... | 185 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P55884-185- | SVIVVD... | 185 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P55884-185- | SVIVVD... | 185 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P55884-451-unknown | TPSMGL... | 451 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17750 | |||
P55884-451-unknown | TPSMGL... | 451 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6054 | |||
P55884-451-unknown | TPSMGL... | 451 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152799 | |||
P55884-530-unknown | VDRTPK... | 530 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169586 | |||
P55884-530- | VDRTPK... | 530 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...AEGLLR | 35 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6052 | |||
...AEGLLR | 35 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121076 | |||
...RSDSRA | 120 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10107 | |||
...RSDSRA | 120 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126761 | |||
...LSIYET | 450 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17750 | |||
...LSIYET | 450 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6054 | |||
...LSIYET | 450 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136224 | |||
...LGNQE | 814 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 35 | GLLR.|.RPAG | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
GRAA_HUMAN | 120 | DSRA.|.AQAV | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:The substrate specificity profi... (S01.135) | 20536382, |
MEP1A_HUMAN | 450 | IYET.|.TPSM | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
CATL1_HUMAN | 450 | IYET.|.TPSM | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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