P28066: Proteasome subunit alpha type-5

General Information

Protein names	- Proteasome subunit alpha type-5 - 3.4.25.1 {ECO:0000269\|PubMed:27176742} - Macropain zeta chain - Multicatalytic endopeptidase complex zeta chain - Proteasome zeta chain
Gene names	PSMA5
Organism	Homo sapiens
Protease Family
Protease ID	T01.975
Chromosome location
UniProt ID	P28066

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFLTRSEYDR GVNTFSPEGR LFQVEYAIEA IKLGSTAIGI QTSEGVCLAV EKRITSPLME
        70         80         90        100        110        120
PSSIEKIVEI DAHIGCAMSG LIADAKTLID KARVETQNHW FTYNETMTVE SVTQAVSNLA
       130        140        150        160        170        180
LQFGEEDADP GAMSRPFGVA LLFGGVDEKG PQLFHMDPSG TFVQCDARAI GSASEGAQSS
       190        200        210        220        230        240
LQEVYHKSMT LKEAIKSSLI ILKQVMEEKL NATNIELATV QPGQNFHMFT KEELEEVIKD

I

Isoforms

- Isoform 2 of Proteasome subunit alpha type-5

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P28066-1-Acetylation	MFLTRS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P28066-1-Acetylation	MFLTRS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P28066-11-	GVNTFS...	11			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P28066-42-	TSEGVC...	42			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P28066-56-unknown	SPLMEP...	56		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P28066-59-unknown	MEPSSI...	59		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86345
P28066-142-unknown	LFGGVD...	142		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3750
P28066-142-unknown	LFGGVD...	142		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141531
P28066-171-unknown	GSASEG...	171		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167648
P28066-171-	GSASEG...	171			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P28066-171-	GSASEG...	171			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P28066-171-	GSASEG...	171			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P28066-231-unknown	KEELEE...	231		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5754
P28066-231-unknown	KEELEE...	231		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145634

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FGVALL	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3750
...FGVALL	141	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124708
...FHMFTK	230	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5754
...FHMFTK	230	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128933
...VIKDI	241	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VIKDI	241	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81963

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	141	VALL.\|.LFGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	230	MFTK.\|.KEEL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)