Q9Y2W2: WW domain-binding protein 11

General Information

Protein names	- WW domain-binding protein 11 - WBP-11 - Npw38-binding protein - NpwBP - SH3 domain-binding protein SNP70 - Splicing factor that interacts with PQBP-1 and PP1
Gene names	WBP11
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y2W2

20 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGRRSTSSTK SGKFMNPTDQ ARKEARKREL KKNKKQRMMV RAAVLKMKDP KQIIRDMEKL
        70         80         90        100        110        120
DEMEFNPVQQ PQLNEKVLKD KRKKLRETFE RILRLYEKEN PDIYKELRKL EVEYEQKRAQ
       130        140        150        160        170        180
LSQYFDAVKN AQHVEVESIP LPDMPHAPSN ILIQDIPLPG AQPPSILKKT SAYGPPTRAV
       190        200        210        220        230        240
SILPLLGHGV PRLPPGRKPP GPPPGPPPPQ VVQMYGRKVG FALDLPPRRR DEDMLYSPEL
       250        260        270        280        290        300
AQRGHDDDVS STSEDDGYPE DMDQDKHDDS TDDSDTDKSD GESDGDEFVH RDNGERDNNE
       310        320        330        340        350        360
EKKSGLSVRF ADMPGKSRKK KKNMKELTPL QAMMLRMAGQ EIPEEGREVE EFSEDDDEDD
       370        380        390        400        410        420
SDDSEAEKQS QKQHKEESHS DGTSTASSQQ QAPPQSVPPS QIQAPPMPGP PPLGPPPAPP
       430        440        450        460        470        480
LRPPGPPTGL PPGPPPGAPP FLRPPGMPGL RGPLPRLLPP GPPPGRPPGP PPGPPPGLPP
       490        500        510        520        530        540
GPPPRGPPPR LPPPAPPGIP PPRPGMMRPP LVPPLGPAPP GLFPPAPLPN PGVLSAPPNL
       550        560        570        580        590        600
IQRPKADDTS AATIEKKATA TISAKPQITN PKAEITRFVP TALRVRRENK GATAAPQRKS
       610        620        630        640
EDDSAVPLAK AAPKSGPSVP VSVQTKDDVY EAFMKEMEGL L

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

20 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y2W2-1-unknown	MGRRST...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y2W2-11-unknown	SGKFMN...	11	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10601
Q9Y2W2-31-unknown	KKNKKQ...	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15155
Q9Y2W2-42-unknown	AAVLKM...	42	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10602
Q9Y2W2-138-	SIPLPD...	138		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y2W2-138-	SIPLPD...	138		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9Y2W2-146-	HAPSNI...	146		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9Y2W2-146-	HAPSNI...	146		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9Y2W2-146-	HAPSNI...	146		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9Y2W2-146-unknown	HAPSNI...	146		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y2W2-169-	KTSAYG...	169		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y2W2-170-	TSAYGP...	170		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y2W2-179-	AVSILP...	179		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9Y2W2-179-	AVSILP...	179		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q9Y2W2-179-	AVSILP...	179		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y2W2-179-	AVSILP...	179		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9Y2W2-179-unknown	AVSILP...	179		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y2W2-179-unknown	AVSILP...	179		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y2W2-220-	GFALDL...	220		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9Y2W2-535-	SAPPNL...	535		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y2W2-558-	ATATIS...	558		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y2W2-559-	TATISA...	559		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y2W2-560-	ATISAK...	560		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y2W2-563-	SAKPQI...	563		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y2W2-564-unknown	AKPQIT...	564	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6939
Q9Y2W2-564-unknown	AKPQIT...	564	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8155
Q9Y2W2-578-unknown	FVPTAL...	578		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y2W2-599-	KSEDDS...	599		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TSSTKS	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10601
...RKRELK	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15155
...RMMVRA	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10602
...DPKQII	53	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440988
...TATISA	563	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6939
...TATISA	563	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8155
...MEGLL	641	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	10	STKS.\|.SGKF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	30	RELK.\|.KKNK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	41	MVRA.\|.AAVL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATL1_HUMAN	563	TISA.\|.AKPQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	563	TISA.\|.AKPQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)