Q03426: Mevalonate kinase {ECO:0000305}

General Information

Protein names	- Mevalonate kinase {ECO:0000305} - MK - 2.7.1.36 {ECO:0000269\|PubMed:18302342, ECO:0000269\|PubMed:9325256}
Gene names	MVK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q03426

5 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLSEVLLVSA PGKVILHGEH AVVHGKVALA VSLNLRTFLR LQPHSNGKVD LSLPNIGIKR
        70         80         90        100        110        120
AWDVARLQSL DTSFLEQGDV TTPTSEQVEK LKEVAGLPDD CAVTERLAVL AFLYLYLSIC
       130        140        150        160        170        180
RKQRALPSLD IVVWSELPPG AGLGSSAAYS VCLAAALLTV CEEIPNPLKD GDCVNRWTKE
       190        200        210        220        230        240
DLELINKWAF QGERMIHGNP SGVDNAVSTW GGALRYHQGK ISSLKRSPAL QILLTNTKVP
       250        260        270        280        290        300
RNTRALVAGV RNRLLKFPEI VAPLLTSIDA ISLECERVLG EMGEAPAPEQ YLVLEELIDM
       310        320        330        340        350        360
NQHHLNALGV GHASLDQLCQ VTRARGLHSK LTGAGGGGCG ITLLKPGLEQ PEVEATKQAL
       370        380        390
TSCGFDCLET SIGAPGVSIH SATSLDSRVQ QALDGL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q03426-1-unknown	MLSEVL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q03426-1-	MLSEVL...	1		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q03426-195-unknown	MIHGNP...	195	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000443182
Q03426-282-unknown	MGEAPA...	282	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439134
Q03426-345-unknown	KPGLEQ...	345	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6222

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NPLKDG	170	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440379
...IHGNPS	200	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438153
...GITLLK	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6222
...ALDGL	396	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	344	TLLK.\|.KPGL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)