P25788: Proteasome subunit alpha type-3

General Information

Protein names	- Proteasome subunit alpha type-3 - 3.4.25.1 {ECO:0000269\|PubMed:27176742} - Macropain subunit C8 - Multicatalytic endopeptidase complex subunit C8 - Proteasome component C8
Gene names	PSMA3
Organism	Homo sapiens
Protease Family
Protease ID	T01.977
Chromosome location
UniProt ID	P25788

9 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSIGTGYDL SASTFSPDGR VFQVEYAMKA VENSSTAIGI RCKDGVVFGV EKLVLSKLYE
        70         80         90        100        110        120
EGSNKRLFNV DRHVGMAVAG LLADARSLAD IAREEASNFR SNFGYNIPLK HLADRVAMYV
       130        140        150        160        170        180
HAYTLYSAVR PFGCSFMLGS YSVNDGAQLY MIDPSGVSYG YWGCAIGKAR QAAKTEIEKL
       190        200        210        220        230        240
QMKEMTCRDI VKEVAKIIYI VHDEVKDKAF ELELSWVGEL TNGRHEIVPK DIREEAEKYA
       250
KESLKEEDES DDDNM

Isoforms

- Isoform 2 of Proteasome subunit alpha type-3

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P25788-1-unknown	MSSIGT...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86343
P25788-2-unknown	MSSIGT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P25788-2-unknown	MSSIGT...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182567
P25788-2-	SSIGTG...	2			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P25788-2-Acetylation	SSIGTG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P25788-2-Acetylation	SSIGTG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P25788-2-Acetylation	SSIGTG...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P25788-2-Acetylation	SSIGTG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P25788-2-Acetylation	SSIGTG...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P25788-2-Acetylation	SSIGTG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111039
P25788-3-	SIGTGY...	3			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P25788-3-unknown	SIGTGY...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182569
P25788-6-	TGYDLS...	6			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P25788-6-unknown	TGYDLS...	6		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182571
P25788-33-unknown	NSSTAI...	33		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5724
P25788-33-unknown	NSSTAI...	33		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137785

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...MKAVEN	32	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5724
...MKAVEN	32	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120786
...DDDNM	255	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...DDDNM	255	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt81961
...DDDNM	255		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DDDNM	255		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...DDDNM	255		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DDDNM	255		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	32	AVEN.\|.NSST	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)