Q16658: Fascin

General Information

Protein names	- Fascin - 55 kDa actin-bundling protein - Singed-like protein - p55
Gene names	FSCN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16658

7 N-termini

6 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTANGTAEAV QIQFGLINCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ PPDEAGSAAV
        70         80         90        100        110        120
CLRSHLGRYL AADKDGNVTC EREVPGPDCR FLIVAHDDGR WSLQSEAHRR YFGGTEDRLS
       130        140        150        160        170        180
CFAQTVSPAE KWSVHIAMHP QVNIYSVTRK RYAHLSARPA DEIAVDRDVP WGVDSLITLA
       190        200        210        220        230        240
FQDQRYSVQT ADHRFLRHDG RLVARPEPAT GYTLEFRSGK VAFRDCEGRY LAPSGPSGTL
       250        260        270        280        290        300
KAGKATKVGK DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR
       310        320        330        340        350        360
DTKKCAFRTH TGKYWTLTAT GGVQSTASSK NASCYFDIEW RDRRITLRAS NGKFVTSKKN
       370        380        390        400        410        420
GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV TGTLDANRSS YDVFQLEFND
       430        440        450        460        470        480
GAYNIKDSTG KYWTVGSDSA VTSSGDTPVD FFFEFCDYNK VAIKVGGRYL KGDHAGVLKA
       490
SAETVDPASL WEY

Isoforms

Sequence View

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Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q16658-2-unknown	MTANGT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16658-2-Acetylation	TANGTA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16658-2-Acetylation	TANGTA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q16658-21-unknown	NKYLTA...	21		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q16658-72-unknown	ADKDGN...	72		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6499
Q16658-72-unknown	ADKDGN...	72		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7885
Q16658-235-	GPSGTL...	235			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q16658-279-unknown	MDLSAN...	279		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000404506
Q16658-279-unknown	MDLSAN...	279		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000409967
Q16658-279-unknown	MDLSAN...	279		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000383982
Q16658-472-unknown	GDHAGV...	472		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6500

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GRYLAA	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6499
...GRYLAA	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7885
...FIGCRK	398	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409967
...ANRSSY	410	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404506
...YDVFQL	415	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000383982
...GRYLKG	471	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6500
...SLWEY	493	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	71	YLAA.\|.ADKD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	71	YLAA.\|.ADKD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	471	YLKG.\|.GDHA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)