Q8ND56: Protein LSM14 homolog A

General Information

Protein names	- Protein LSM14 homolog A - Protein FAM61A - Protein SCD6 homolog - Putative alpha-synuclein-binding protein - AlphaSNBP - RNA-associated protein 55A - hRAP55 - hRAP55A
Gene names	LSM14A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8ND56

17 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein LSM14 homolog A - Isoform 3 of Protein LSM14 homolog A

Sequence View

        10         20         30         40         50         60
MSGGTPYIGS KISLISKAEI RYEGILYTID TENSTVALAK VRSFGTEDRP TDRPIPPRDE
        70         80         90        100        110        120
VFEYIIFRGS DIKDLTVCEP PKPQCSLPQD PAIVQSSLGS STSSFQSMGS YGPFGRMPTY
       130        140        150        160        170        180
SQFSPSSLVG QQFGAVGVAG SSLTSFGTET SNSGTLPQSS AVGSAFTQDT RSLKTQLSQG
       190        200        210        220        230        240
RSSPQLDPLR KSPTMEQAVQ TASAHLPAPA AVGRRSPVST RPLPSASQKA GENQEHRRAE
       250        260        270        280        290        300
VHKVSRPENE QLRNDNKRQV APGAPSAPRR GRGGHRGGRG RFGIRRDGPM KFEKDFDFES
       310        320        330        340        350        360
ANAQFNKEEI DREFHNKLKL KEDKLEKQEK PVNGEDKGDS GVDTQNSEGN ADEEDPLGPN
       370        380        390        400        410        420
CYYDKTKSFF DNISCDDNRE RRPTWAEERR LNAETFGIPL RPNRGRGGYR GRGGLGFRGG
       430        440        450        460
RGRGGGRGGT FTAPRGFRGG FRGGRGGREF ADFEYRKTTA FGP         10         20         30         40         50         60
MSGGTPYIGS KISLISKAEI RYEGILYTID TENSTVALAK VRSFGTEDRP TDRPIPPRDE
        70         80         90        100        110        120
VFEYIIFRGS DIKDLTVCEP PKPQCSLPQD PAIVQSSLGS STSSFQSMGS YGPFGRMPTY
       130        140        150        160        170        180
SQFSPSSLVG QQFGAVGVAG SSLTSFGTET SNSGTLPQSS AVGSAFTQDT RSLKTQLSQG
       190        200        210        220        230        240
RSSPQLDPLR KSPTMEQAVQ TASAHLPAPA AVGRRSPVST RPLPSASQKA GENQEHRRAE
       250        260        270        280        290        300
VHKVSRPENE QLRNDNKRQV APGAPSAPRR GRGGHRGGRG RFGIRRDGPM KFEKDFDFES
       310        320        330        340        350        360
ANAQFNKEEI DREFHNKLKL KEDKLEKQEK PVNGEDKGDS GVDTQNSEGN ADEEDPLGPN
       370        380        390        400        410        420
CYYDKTKSFF DNISCDDNRE RRPTWAEERR LNAETFGIPL RPNRGRGGYR GRGGLGFRGG
       430        440        450        460
RGRGGGRGGT FTAPRGFRGG FRGGRGGREF ADFEYRKTTA FGP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

17 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8ND56-1-unknown	MSGGTP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79996
Q8ND56-2-unknown	MSGGTP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8ND56-2-Acetylation	SGGTPY...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8ND56-2-Acetylation	SGGTPY...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8ND56-2-Acetylation	SGGTPY...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q8ND56-2-Acetylation	SGGTPY...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110368
Q8ND56-33-unknown	NSTVAL...	33		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12898
Q8ND56-33-unknown	NSTVAL...	33		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137788
Q8ND56-103-	SSFQSM...	103			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8ND56-103-unknown	SSFQSM...	103		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166463
Q8ND56-104-	SFQSMG...	104			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8ND56-104-	SFQSMG...	104			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8ND56-104-	SFQSMG...	104			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8ND56-104-	SFQSMG...	104			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q8ND56-104-	SFQSMG...	104			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8ND56-104-	SFQSMG...	104			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8ND56-104-unknown	SFQSMG...	104			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8ND56-104-unknown	SFQSMG...	104		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159882
Q8ND56-161-	AVGSAF...	161			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8ND56-161-unknown	AVGSAF...	161		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166468
Q8ND56-172-unknown	SLKTQL...	172		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10440
Q8ND56-172-unknown	SLKTQL...	172		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145607
Q8ND56-172-	SLKTQL...	172			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q8ND56-172-	SLKTQL...	172			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q8ND56-198-	AVQTAS...	198			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8ND56-198-unknown	AVQTAS...	198		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172304
Q8ND56-203-	SAHLPA...	203			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8ND56-203-	SAHLPA...	203			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8ND56-203-	SAHLPA...	203			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8ND56-203-	SAHLPA...	203			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8ND56-203-unknown	SAHLPA...	203		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166466
Q8ND56-220-unknown	TRPLPS...	220		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7957
Q8ND56-220-unknown	TRPLPS...	220		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6585
Q8ND56-220-unknown	TRPLPS...	220		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147343

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TIDTEN	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12898
...TIDTEN	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120789
...TQDTRS	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10440
...TQDTRS	171	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128905
...RSPVST	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7957
...RSPVST	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6585
...RSPVST	219	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130686
...TAFGP	463	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	32	DTEN.\|.NSTV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAA_HUMAN	171	DTRS.\|.SLKT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATS_HUMAN	219	PVST.\|.TRPL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	219	PVST.\|.TRPL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)