Q9Y2W1: Thyroid hormone receptor-associated protein 3

General Information

Protein names	- Thyroid hormone receptor-associated protein 3 - BCLAF1 and THRAP3 family member 2 {ECO:0000312\|HGNC:HGNC:22964} - Thyroid hormone receptor-associated protein complex 150 kDa component - Trap150
Gene names	THRAP3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y2W1

17 N-termini

10 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSKTNKSKSG SRSSRSRSAS RSRSRSFSKS RSRSRSLSRS RKRRLSSRSR SRSYSPAHNR
        70         80         90        100        110        120
ERNHPRVYQN RDFRGHNRGY RRPYYFRGRN RGFYPWGQYN RGGYGNYRSN WQNYRQAYSP
       130        140        150        160        170        180
RRGRSRSRSP KRRSPSPRSR SHSRNSDKSS SDRSRRSSSS RSSSNHSRVE SSKRKSAKEK
       190        200        210        220        230        240
KSSSKDSRPS QAAGDNQGDE AKEQTFSGGT SQDTKASESS KPWPDATYGT GSASRASAVS
       250        260        270        280        290        300
ELSPRERSPA LKSPLQSVVV RRRSPRPSPV PKPSPPLSST SQMGSTLPSG AGYQSGTHQG
       310        320        330        340        350        360
QFDHGSGSLS PSKKSPVGKS PPSTGSTYGS SQKEESAASG GAAYTKRYLE EQKTENGKDK
       370        380        390        400        410        420
EQKQTNTDKE KIKEKGSFSD TGLGDGKMKS DSFAPKTDSE KPFRGSQSPK RYKLRDDFEK
       430        440        450        460        470        480
KMADFHKEEM DDQDKDKAKG RKESEFDDEP KFMSKVIGAN KNQEEEKSGK WEGLVYAPPG
       490        500        510        520        530        540
KEKQRKTEEL EEESFPERSK KEDRGKRSEG GHRGFVPEKN FRVTAYKAVQ EKSSSPPPRK
       550        560        570        580        590        600
TSESRDKLGA KGDFPTGKSS FSITREAQVN VRMDSFDEDL ARPSGLLAQE RKLCRDLVHS
       610        620        630        640        650        660
NKKEQEFRSI FQHIQSAQSQ RSPSELFAQH IVTIVHHVKE HHFGSSGMTL HERFTKYLKR
       670        680        690        700        710        720
GTEQEAAKNK KSPEIHRRID ISPSTFRKHG LAHDEMKSPR EPGYKAEGKY KDDPVDLRLD
       730        740        750        760        770        780
IERRKKHKER DLKRGKSRES VDSRDSSHSR ERSAEKTEKT HKGSKKQKKH RRARDRSRSS
       790        800        810        820        830        840
SSSSQSSHSY KAEEYTEETE EREESTTGFD KSRLGTKDFV GPSERGGGRA RGTFQFRARG
       850        860        870        880        890        900
RGWGRGNYSG NNNNNSNNDF QKRNREEEWD PEYTPKSKKY YLHDDREGEG SDKWVSRGRG
       910        920        930        940        950
RGAFPRGRGR FMFRKSSTSP KWAHDKFSGE EGEIEDDESG TENREEKDNI QPTTE

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Protein Neighborhood

Domains & Features

17 N-termini - 10 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y2W1-2-unknown	MSKTNK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y2W1-2-Acetylation	SKTNKS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y2W1-2-Acetylation	SKTNKS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9Y2W1-2-Acetylation	SKTNKS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9Y2W1-226-unknown	ATYGTG...	226		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13604
Q9Y2W1-236-unknown	ASAVSE...	236		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10599
Q9Y2W1-248-	SPALKS...	248			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y2W1-392-unknown	SFAPKT...	392		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13605
Q9Y2W1-392-unknown	SFAPKT...	392		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3232
Q9Y2W1-425-unknown	FHKEEM...	425		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13606
Q9Y2W1-452-	FMSKVI...	452			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y2W1-475-unknown	VYAPPG...	475		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15154
Q9Y2W1-486-	KTEELE...	486			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y2W1-523-	VTAYKA...	523			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y2W1-552-	GDFPTG...	552			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y2W1-573-unknown	MDSFDE...	573		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10600
Q9Y2W1-575-	SFDEDL...	575			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9Y2W1-575-	SFDEDL...	575			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y2W1-575-	SFDEDL...	575			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9Y2W1-575-unknown	SFDEDL...	575		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13607
Q9Y2W1-789-	SYKAEE...	789			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9Y2W1-850-unknown	GNNNNN...	850		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6938

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SLSRSR	40	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000433066
...KPWPDA	225	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13604
...GSASRA	235	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10599
...KMKSDS	391	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13605
...KMKSDS	391	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3232
...KKMADF	424	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13606
...KWEGLV	474	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15154
...QVNVRM	572	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10600
...NVRMDS	574	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13607
...RGNYSG	849	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6938
...QPTTE	955	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...QPTTE	955		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	225	WPDA.\|.ATYG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAA_HUMAN	235	ASRA.\|.ASAV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	391	KSDS.\|.SFAP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASPE_HUMAN	391	KSDS.\|.SFAP	inferred from experiment	unknown	MEROPS		Merops CASPE_HUMAN -> TR150_HUMAN @391
GRAB_HUMAN	424	MADF.\|.FHKE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	474	EGLV.\|.VYAP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	572	NVRM.\|.MDSF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	574	RMDS.\|.SFDE	inferred from experiment	unknown	MEROPS		Merops GRAB_HUMAN -> TR150_HUMAN @574
GRAB_HUMAN	574	RMDS.\|.SFDE	inferred from experiment	unknown	MEROPS	Gevaert K	Plasman K et al.:Probing the efficiency of prote... (S01.010)	21048194,
CATL1_HUMAN	849	NYSG.\|.GNNN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)