Q16181: Septin-7

General Information

Protein names	- Septin-7 - CDC10 protein homolog
Gene names	SEPT7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16181

10 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSVSARSAAA EERSVNSSTM VAQQKNLEGY VGFANLPNQV YRKSVKRGFE FTLMVVGESG
        70         80         90        100        110        120
LGKSTLINSL FLTDLYSPEY PGPSHRIKKT VQVEQSKVLI KEGGVQLLLT IVDTPGFGDA
       130        140        150        160        170        180
VDNSNCWQPV IDYIDSKFED YLNAESRVNR RQMPDNRVQC CLYFIAPSGH GLKPLDIEFM
       190        200        210        220        230        240
KRLHEKVNII PLIAKADTLT PEECQQFKKQ IMKEIQEHKI KIYEFPETDD EEENKLVKKI
       250        260        270        280        290        300
KDRLPLAVVG SNTIIEVNGK RVRGRQYPWG VAEVENGEHC DFTILRNMLI RTHMQDLKDV
       310        320        330        340        350        360
TNNVHYENYR SRKLAAVTYN GVDNNKNKGQ LTKSPLAQME EERREHVAKM KKMEMEMEQV
       370        380        390        400        410        420
FEMKVKEKVQ KLKDSEAELQ RRHEQMKKNL EAQHKELEEK RRQFEDEKAN WEAQQRILEQ
       430
QNSSRTLEKN KKKGKIF

Isoforms

- Isoform 2 of Septin-7

Sequence View

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Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q16181-2-unknown	MSVSAR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16181-2-Acetylation	SVSARS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16181-21-	VAQQKN...	21			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q16181-21-	VAQQKN...	21			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q16181-21-	VAQQKN...	21			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q16181-21-	VAQQKN...	21			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q16181-21-	VAQQKN...	21			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q16181-21-	VAQQKN...	21			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q16181-54-unknown	MVVGES...	54		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000413507
Q16181-54-unknown	MVVGES...	54		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132314
Q16181-77-unknown	SPEYPG...	77		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6484
Q16181-77-unknown	SPEYPG...	77		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7870
Q16181-77-unknown	SPEYPG...	77		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141034
Q16181-321-unknown	GVDNNK...	321			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q16181-321-unknown	GVDNNK...	321		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162087
Q16181-321-	GVDNNK...	321			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q16181-334-	SPLAQM...	334			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q16181-334-unknown	SPLAQM...	334		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176152
Q16181-350-unknown	MKKMEM...	350		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444240
Q16181-350-unknown	MKKMEM...	350		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132316

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LTDLYS	76	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6484
...LTDLYS	76	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7870
...LTDLYS	76	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124184
...KKGKIF	436	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8248
...KKGKIF	436	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt135984
...KGKIF	437	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KGKIF	437	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt84915
...KGKIF	437		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KGKIF	437		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KGKIF	437		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KGKIF	437		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	76	DLYS.\|.SPEY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	76	DLYS.\|.SPEY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CBPA4_HUMAN	436	GKIF.\|.F	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)