Q05519: Serine/arginine-rich splicing factor 11

General Information

Protein names	- Serine/arginine-rich splicing factor 11 - Arginine-rich 54 kDa nuclear protein - p54 - Splicing factor, arginine/serine-rich 11
Gene names	SRSF11
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q05519

13 N-termini

9 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSNTTVVPST AGPGPSGGPG GGGGGGGGGG GTEVIQVTNV SPSASSEQMR TLFGFLGKID
        70         80         90        100        110        120
ELRLFPPDDS PLPVSSRVCF VKFHDPDSAV VAQHLTNTVF VDRALIVVPY AEGVIPDEAK
       130        140        150        160        170        180
ALSLLAPANA VAGLLPGGGL LPTPNPLTQI GAVPLAALGA PTLDPALAAL GLPGANLNSQ
       190        200        210        220        230        240
SLAADQLLKL MSTVDPKLNH VAAGLVSPSL KSDTSSKEIE EAMKRVREAQ SLISAAIEPD
       250        260        270        280        290        300
KKEEKRRHSR SRSRSRRRRT PSSSRHRRSR SRSRRRSHSK SRSRRRSKSP RRRRSHSRER
       310        320        330        340        350        360
GRRSRSTSKT RDKKKEDKEK KRSKTPPKSY STARRSRSAS RERRRRRSRS GTRSPKKPRS
       370        380        390        400        410        420
PKRKLSRSPS PRRHKKEKKK DKDKERSRDE RERSTSKKKK SKDKEKDRER KSESDKDVKQ
       430        440        450        460        470        480
VTRDYDEEEQ GYDSEKEKKE EKKPIETGSP KTKECSVEKG TGDSLRESKV NGDDHHEEDM

DMSD

Isoforms

- Isoform 2 of Serine/arginine-rich splicing factor 11

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

13 N-termini - 9 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q05519-1-unknown	MSNTTV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90728
Q05519-2-unknown	MSNTTV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q05519-2-Acetylation	SNTTVV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q05519-2-Acetylation	SNTTVV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111737
Q05519-157-unknown	ALGAPT...	157		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167778
Q05519-157-	ALGAPT...	157			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q05519-157-	ALGAPT...	157			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q05519-157-	ALGAPT...	157			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q05519-203-unknown	AGLVSP...	203		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6234
Q05519-203-unknown	AGLVSP...	203		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146645
Q05519-205-unknown	LVSPSL...	205		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3964
Q05519-205-unknown	LVSPSL...	205		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146717
Q05519-206-unknown	VSPSLK...	206		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14370
Q05519-206-unknown	VSPSLK...	206		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146739
Q05519-207-unknown	SPSLKS...	207		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6236
Q05519-207-unknown	SPSLKS...	207		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146793
Q05519-210-unknown	LKSDTS...	210		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14372
Q05519-210-unknown	LKSDTS...	210		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146945
Q05519-233-unknown	ISAAIE...	233		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14374
Q05519-233-unknown	ISAAIE...	233		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147832
Q05519-241-unknown	KKEEKR...	241		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11920
Q05519-241-unknown	KKEEKR...	241		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148147
Q05519-474-unknown	DHHEED...	474		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11922
Q05519-474-unknown	DHHEED...	474		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153110

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LNHVAA	202	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6234
...LNHVAA	202	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129954
...HVAAGL	204	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3964
...HVAAGL	204	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130029
...VAAGLV	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14370
...VAAGLV	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130051
...AAGLVS	206	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6236
...AAGLVS	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130115
...LVSPSL	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14372
...LVSPSL	209	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130276
...EAQSLI	232	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14374
...EAQSLI	232	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131186
...AIEPDK	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11920
...AIEPDK	240	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131514
...KVNGDD	473	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11922
...KVNGDD	473	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136535
...MDMSD	484	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MDMSD	484	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86346

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	202	HVAA.\|.AGLV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	204	AAGL.\|.LVSP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	205	AGLV.\|.VSPS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	206	GLVS.\|.SPSL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	209	SPSL.\|.LKSD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	232	QSLI.\|.ISAA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	240	EPDK.\|.KKEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	473	NGDD.\|.DHHE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)