Q8WUM4: Programmed cell death 6-interacting protein

General Information

Protein names	- Programmed cell death 6-interacting protein - PDCD6-interacting protein - ALG-2-interacting protein 1 - ALG-2-interacting protein X - Hp95
Gene names	PDCD6IP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8WUM4

7 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Programmed cell death 6-interacting protein - Isoform 3 of Programmed cell death 6-interacting protein

Sequence View

        10         20         30         40         50         60
MATFISVQLK KTSEVDLAKP LVKFIQQTYP SGGEEQAQYC RAAEELSKLR RAAVGRPLDK
        70         80         90        100        110        120
HEGALETLLR YYDQICSIEP KFPFSENQIC LTFTWKDAFD KGSLFGGSVK LALASLGYEK
       130        140        150        160        170        180
SCVLFNCAAL ASQIAAEQNL DNDEGLKIAA KHYQFASGAF LHIKETVLSA LSREPTVDIS
       190        200        210        220        230        240
PDTVGTLSLI MLAQAQEVFF LKATRDKMKD AIIAKLANQA ADYFGDAFKQ CQYKDTLPKE
       250        260        270        280        290        300
VFPVLAAKHC IMQANAEYHQ SILAKQQKKF GEEIARLQHA AELIKTVASR YDEYVNVKDF
       310        320        330        340        350        360
SDKINRALAA AKKDNDFIYH DRVPDLKDLD PIGKATLVKS TPVNVPISQK FTDLFEKMVP
       370        380        390        400        410        420
VSVQQSLAAY NQRKADLVNR SIAQMREATT LANGVLASLN LPAAIEDVSG DTVPQSILTK
       430        440        450        460        470        480
SRSVIEQGGI QTVDQLIKEL PELLQRNREI LDESLRLLDE EEATDNDLRA KFKERWQRTP
       490        500        510        520        530        540
SNELYKPLRA EGTNFRTVLD KAVQADGQVK ECYQSHRDTI VLLCKPEPEL NAAIPSANPA
       550        560        570        580        590        600
KTMQGSEVVN VLKSLLSNLD EVKKEREGLE NDLKSVNFDM TSKFLTALAQ DGVINEEALS
       610        620        630        640        650        660
VTELDRVYGG LTTKVQESLK KQEGLLKNIQ VSHQEFSKMK QSNNEANLRE EVLKNLATAY
       670        680        690        700        710        720
DNFVELVANL KEGTKFYNEL TEILVRFQNK CSDIVFARKT ERDELLKDLQ QSIAREPSAP
       730        740        750        760        770        780
SIPTPAYQSS PAGGHAPTPP TPAPRTMPPT KPQPPARPPP PVLPANRAPS ATAPSPVGAG
       790        800        810        820        830        840
TAAPAPSQTP GSAPPPQAQG PPYPTYPGYP GYCQMPMPMG YNPYAYGQYN MPYPPVYHQS
       850        860
PGQAPYPGPQ QPSYPFPQPP QQSYYPQQ         10         20         30         40         50         60
MATFISVQLK KTSEVDLAKP LVKFIQQTYP SGGEEQAQYC RAAEELSKLR RAAVGRPLDK
        70         80         90        100        110        120
HEGALETLLR YYDQICSIEP KFPFSENQIC LTFTWKDAFD KGSLFGGSVK LALASLGYEK
       130        140        150        160        170        180
SCVLFNCAAL ASQIAAEQNL DNDEGLKIAA KHYQFASGAF LHIKETVLSA LSREPTVDIS
       190        200        210        220        230        240
PDTVGTLSLI MLAQAQEVFF LKATRDKMKD AIIAKLANQA ADYFGDAFKQ CQYKDTLPKE
       250        260        270        280        290        300
VFPVLAAKHC IMQANAEYHQ SILAKQQKKF GEEIARLQHA AELIKTVASR YDEYVNVKDF
       310        320        330        340        350        360
SDKINRALAA AKKDNDFIYH DRVPDLKDLD PIGKATLVKS TPVNVPISQK FTDLFEKMVP
       370        380        390        400        410        420
VSVQQSLAAY NQRKADLVNR SIAQMREATT LANGVLASLN LPAAIEDVSG DTVPQSILTK
       430        440        450        460        470        480
SRSVIEQGGI QTVDQLIKEL PELLQRNREI LDESLRLLDE EEATDNDLRA KFKERWQRTP
       490        500        510        520        530        540
SNELYKPLRA EGTNFRTVLD KAVQADGQVK ECYQSHRDTI VLLCKPEPEL NAAIPSANPA
       550        560        570        580        590        600
KTMQGSEVVN VLKSLLSNLD EVKKEREGLE NDLKSVNFDM TSKFLTALAQ DGVINEEALS
       610        620        630        640        650        660
VTELDRVYGG LTTKVQESLK KQEGLLKNIQ VSHQEFSKMK QSNNEANLRE EVLKNLATAY
       670        680        690        700        710        720
DNFVELVANL KEGTKFYNEL TEILVRFQNK CSDIVFARKT ERDELLKDLQ QSIAREPSAP
       730        740        750        760        770        780
SIPTPAYQSS PAGGHAPTPP TPAPRTMPPT KPQPPARPPP PVLPANRAPS ATAPSPVGAG
       790        800        810        820        830        840
TAAPAPSQTP GSAPPPQAQG PPYPTYPGYP GYCQMPMPMG YNPYAYGQYN MPYPPVYHQS
       850        860
PGQAPYPGPQ QPSYPFPQPP QQSYYPQQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8WUM4-2-unknown	MATFIS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WUM4-1-unknown	MATFIS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84634
Q8WUM4-2-Acetylation	ATFISV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WUM4-2-Acetylation	ATFISV...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q8WUM4-2-Acetylation	ATFISV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110383
Q8WUM4-457-acetylation	LLDEEE...	457	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q8WUM4-457-acetylation	LLDEEE...	457	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183172
Q8WUM4-628-unknown	NIQVSH...	628		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172495
Q8WUM4-628-	NIQVSH...	628			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WUM4-733-unknown	GGHAPT...	733		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6602
Q8WUM4-733-unknown	GGHAPT...	733		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156191

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QSSPAG	732	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6602
...QSSPAG	732	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139656
...YYPQQ	868	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YYPQQ	868	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80252

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	732	SPAG.\|.GGHA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)