Q96FW1: Ubiquitin thioesterase OTUB1

General Information

Protein names	- Ubiquitin thioesterase OTUB1 - 3.4.19.12 {ECO:0000269\|PubMed:23827681} - Deubiquitinating enzyme OTUB1 - OTU domain-containing ubiquitin aldehyde-binding protein 1 - Otubain-1 - hOTU1 - Ubiquitin-specific-processing protease OTUB1
Gene names	OTUB1
Organism	Homo sapiens
Protease Family
Protease ID	C65.001
Chromosome location
UniProt ID	Q96FW1

8 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE
        70         80         90        100        110        120
YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK
       130        140        150        160        170        180
SKEDLVSQGF TEFTIEDFHN TFMDLIEQVE KQTSVADLLA SFNDQSTSDY LVVYLRLLTS
       190        200        210        220        230        240
GYLQRESKFF EHFIEGGRTV KEFCQQEVEP MCKESDHIHI IALAQALSVS IQVEYMDRGE
       250        260        270
GGTTNPHIFP EGSEPKVYLL YRPGHYDILY K

Isoforms

- Isoform 2 of Ubiquitin thioesterase OTUB1

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96FW1-2-unknown	MAAEEP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96FW1-2-Acetylation	AAEEPQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96FW1-2-Acetylation	AAEEPQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q96FW1-2-Acetylation	AAEEPQ...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q96FW1-3-	AEEPQQ...	3			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q96FW1-3-acetylation	AEEPQQ...	3	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q96FW1-18-unknown	SEGVNC...	18		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13061
Q96FW1-25-	AYDEAI...	25			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q96FW1-28-unknown	EAIMAQ...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13062
Q96FW1-43-unknown	VQNPLV...	43		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6675

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PLGSDS	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13061
...CLAYDE	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13062
...QQEIAV	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6675
...DILYK	271	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DILYK	271	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79535

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	17	GSDS.\|.SEGV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	27	AYDE.\|.EAIM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	42	EIAV.\|.VQNP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)