P42765: 3-ketoacyl-CoA thiolase, mitochondrial {ECO:0000305}

General Information

Protein names	- 3-ketoacyl-CoA thiolase, mitochondrial {ECO:0000305} - 2.3.1.16 {ECO:0000269\|PubMed:25478839} - Acetyl-CoA acetyltransferase {ECO:0000305} - 2.3.1.9 {ECO:0000269\|PubMed:25478839} - Acetyl-CoA acyltransferase - Acyl-CoA hydrolase, mitochondrial {ECO:0000305} - 3.1.2.- {ECO:0000269\|PubMed:25478839} - 3.1.2.1 {ECO:0000269\|PubMed:25478839} - 3.1.2.2 {ECO:0000250\|UniProtKB:P13437} - Beta-ketothiolase - Mitochondrial 3-oxoacyl-CoA thiolase - T1
Gene names	ACAA2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P42765

4 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALLRGVFVV AAKRTPFGAY GGLLKDFTAT DLSEFAAKAA LSAGKVSPET VDSVIMGNVL
        70         80         90        100        110        120
QSSSDAIYLA RHVGLRVGIP KETPALTINR LCGSGFQSIV NGCQEICVKE AEVVLCGGTE
       130        140        150        160        170        180
SMSQAPYCVR NVRFGTKLGS DIKLEDSLWV SLTDQHVQLP MAMTAENLAV KHKISREECD
       190        200        210        220        230        240
KYALQSQQRW KAANDAGYFN DEMAPIEVKT KKGKQTMQVD EHARPQTTLE QLQKLPPVFK
       250        260        270        280        290        300
KDGTVTAGNA SGVADGAGAV IIASEDAVKK HNFTPLARIV GYFVSGCDPS IMGIGPVPAI
       310        320        330        340        350        360
SGALKKAGLS LKDMDLVEVN EAFAPQYLAV ERSLDLDISK TNVNGGAIAL GHPLGGSGSR
       370        380        390
ITAHLVHELR RRGGKYAVGS ACIGGGQGIA VIIQSTA

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P42765-1-unknown	MALLRG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P42765-56-unknown	MGNVLQ...	56	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000466466
P42765-56-unknown	MGNVLQ...	56	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000465045
P42765-56-unknown	MGNVLQ...	56	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000465095
P42765-56-unknown	MGNVLQ...	56	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000468157
P42765-102-unknown	GCQEIC...	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5870
P42765-345-	GGAIAL...	345		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QSIVNG	101	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5870
...SQAPYC	127	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468157
...GTKLGS	139	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465095
...SREECD	179	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465045
...IQSTA	397	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	101	IVNG.\|.GCQE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)