P27797: Calreticulin {ECO:0000303|PubMed:9427624}

General Information

Protein names	- Calreticulin {ECO:0000303\|PubMed:9427624} - CRP55 - Calregulin - Endoplasmic reticulum resident protein 60 - ERp60 - HACBP - grp60
Gene names	CALR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P27797

23 N-termini

8 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLLSVPLLLG LLGLAVAEPA VYFKEQFLDG DGWTSRWIES KHKSDFGKFV LSSGKFYGDE
        70         80         90        100        110        120
EKDKGLQTSQ DARFYALSAS FEPFSNKGQT LVVQFTVKHE QNIDCGGGYV KLFPNSLDQT
       130        140        150        160        170        180
DMHGDSEYNI MFGPDICGPG TKKVHVIFNY KGKNVLINKD IRCKDDEFTH LYTLIVRPDN
       190        200        210        220        230        240
TYEVKIDNSQ VESGSLEDDW DFLPPKKIKD PDASKPEDWD ERAKIDDPTD SKPEDWDKPE
       250        260        270        280        290        300
HIPDPDAKKP EDWDEEMDGE WEPPVIQNPE YKGEWKPRQI DNPDYKGTWI HPEIDNPEYS
       310        320        330        340        350        360
PDPSIYAYDN FGVLGLDLWQ VKSGTIFDNF LITNDEAYAE EFGNETWGVT KAAEKQMKDK
       370        380        390        400        410
QDEEQRLKEE EEDKKRKEEE EAEDKEDDED KDEDEEDEED KEEDEEEDVP GQAKDEL

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

23 N-termini - 8 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P27797-18-unknown	EPAVYF...	18	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P27797-18-	EPAVYF...	18		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P27797-20-	AVYFKE...	20		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P27797-20-	AVYFKE...	20		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P27797-20-	AVYFKE...	20		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P27797-20-	AVYFKE...	20		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P27797-22-	YFKEQF...	22		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P27797-42-unknown	HKSDFG...	42		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P27797-42-	HKSDFG...	42		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P27797-49-	FVLSSG...	49		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P27797-52-unknown	SSGKFY...	52	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14068
P27797-53-	SGKFYG...	53		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P27797-56-	FYGDEE...	56		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P27797-78-	SASFEP...	78		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P27797-116-	SLDQTD...	116		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P27797-133-unknown	GPDICG...	133	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17537
P27797-152-unknown	GKNVLI...	152	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5743
P27797-177-unknown	RPDNTY...	177	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5744
P27797-189-	SQVESG...	189		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P27797-189-	SQVESG...	189		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P27797-208-	IKDPDA...	208		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P27797-208-	IKDPDA...	208		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P27797-213-unknown	ASKPED...	213	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17538
P27797-213-	ASKPED...	213		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P27797-214-unknown	SKPEDW...	214	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17539
P27797-259-	GEWEPP...	259		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P27797-259-	GEWEPP...	259		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P27797-259-	GEWEPP...	259		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P27797-329-	NFLITN...	329		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P27797-330-	FLITND...	330		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GKFVLS	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14068
...YNIMFG	132	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17537
...IFNYKG	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5743
...YTLIVR	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5744
...IKDPDA	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17538
...KDPDAS	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17539
...FGVLGL	315	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465105
...AKDEL	417	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	51	FVLS.\|.SSGK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1A_HUMAN	132	IMFG.\|.GPDI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	151	NYKG.\|.GKNV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	176	LIVR.\|.RPDN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	212	DPDA.\|.ASKP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	213	PDAS.\|.SKPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)