Q9H583: HEAT repeat-containing protein 1

General Information

Protein names	- HEAT repeat-containing protein 1 - Protein BAP28 - U3 small nucleolar RNA-associated protein 10 homolog - HEAT repeat-containing protein 1, N-terminally processed
Gene names	HEATR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H583

4 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTSLAQQLQR LALPQSDASL LSRDEVASLL FDPKEAATID RDTAFAIGCT GLEELLGIDP
        70         80         90        100        110        120
SFEQFEAPLF SQLAKTLERS VQTKAVNKQL DENISLFLIH LSPYFLLKPA QKCLEWLIHR
       130        140        150        160        170        180
FHIHLYNQDS LIACVLPYHE TRIFVRVIQL LKINNSKHRW FWLLPVKQSG VPLAKGTLIT
       190        200        210        220        230        240
HCYKDLGFMD FICSLVTKSV KVFAEYPGSS AQLRVLLAFY ASTIVSALVA AEDVSDNIIA
       250        260        270        280        290        300
KLFPYIQKGL KSSLPDYRAA TYMIICQISV KVTMENTFVN SLASQIIKTL TKIPSLIKDG
       310        320        330        340        350        360
LSCLIVLLQR QKPESLGKKP FPHLCNVPDL ITILHGISET YDVSPLLHYM LPHLVVSIIH
       370        380        390        400        410        420
HVTGEETEGM DGQIYKRHLE AILTKISLKN NLDHLLASLL FEEYISYSSQ EEMDSNKVSL
       430        440        450        460        470        480
LNEQFLPLIR LLESKYPRTL DVVLEEHLKE IADLKKQELF HQFVSLSTSG GKYQFLADSD
       490        500        510        520        530        540
TSLMLSLNHP LAPVRILAMN HLKKIMKTSK EGVDESFIKE AVLARLGDDN IDVVLSAISA
       550        560        570        580        590        600
FEIFKEHFSS EVTISNLLNL FQRAELSKNG EWYEVLKIAA DILIKEEILS ENDQLSNQVV
       610        620        630        640        650        660
VCLLPFMVIN NDDTESAEMK IAIYLSKSGI CSLHPLLRGW EEALENVIKS TKPGKLIGVA
       670        680        690        700        710        720
NQKMIELLAD NINLGDPSSM LKMVEDLISV GEEESFNLKQ KVTFHVILSV LVSCCSSLKE
       730        740        750        760        770        780
THFPFAIRVF SLLQKKIKKL ESVITAVEIP SEWHIELMLD RGIPVELWAH YVEELNSTQR
       790        800        810        820        830        840
VAVEDSVFLV FSLKKFIYAL KAPKSFPKGD IWWNPEQLKE DSRDYLHLLI GLFEMMLNGA
       850        860        870        880        890        900
DAVHFRVLMK LFIKVHLEDV FQLFKFCSVL WTYGSSLSNP LNCSVKTVLQ TQALYVGCAM
       910        920        930        940        950        960
LSSQKTQCKH QLASISSPVV TSLLINLGSP VKEVRRAAIQ CLQALSGVAS PFYLIIDHLI
       970        980        990       1000       1010       1020
SKAEEITSDA AYVIQDLATL FEELQREKKL KSHQKLSETL KNLLSCVYSC PSYIAKDLMK
      1030       1040       1050       1060       1070       1080
VLQGVNGEMV LSQLLPMAEQ LLEKIQKEPT AVLKDEAMVL HLTLGKYNEF SVSLLNEDPK
      1090       1100       1110       1120       1130       1140
SLDIFIKAVH TTKELYAGMP TIQITALEKI TKPFFAAISD EKVQQKLLRM LFDLLVNCKN
      1150       1160       1170       1180       1190       1200
SHCAQTVSSV FKGISVNAEQ VRIELEPPDK AKPLGTVQQK RRQKMQQKKS QDLESVQEVG
      1210       1220       1230       1240       1250       1260
GSYWQRVTLI LELLQHKKKL RSPQILVPTL FNLLSRCLEP LPQEQGNMEY TKQLILSCLL
      1270       1280       1290       1300       1310       1320
NICQKLSPDG GKIPKDILDE EKFNVELIVQ CIRLSEMPQT HHHALLLLGT VAGIFPDKVL
      1330       1340       1350       1360       1370       1380
HNIMSIFTFM GANVMRLDDT YSFQVINKTV KMVIPALIQS DSGDSIEVSR NVEEIVVKII
      1390       1400       1410       1420       1430       1440
SVFVDALPHV PEHRRLPILV QLVDTLGAEK FLWILLILLF EQYVTKTVLA AAYGEKDAIL
      1450       1460       1470       1480       1490       1500
EADTEFWFSV CCEFSVQHQI QSLMNILQYL LKLPEEKEET IPKAVSFNKS ESQEEMLQVF
      1510       1520       1530       1540       1550       1560
NVETHTSKQL RHFKFLSVSF MSQLLSSNNF LKKVVESGGP EILKGLEERL LETVLGYISA
      1570       1580       1590       1600       1610       1620
VAQSMERNAD KLTVKFWRAL LSKAYDLLDK VNALLPTETF IPVIRGLVGN PLPSVRRKAL
      1630       1640       1650       1660       1670       1680
DLLNNKLQQN ISWKKTIVTR FLKLVPDLLA IVQRKKKEGE EEQAINRQTA LYTLKLLCKN
      1690       1700       1710       1720       1730       1740
FGAENPDPFV PVLNTAVKLI APERKEEKNV LGSALLCIAE VTSTLEALAI PQLPSLMPSL
      1750       1760       1770       1780       1790       1800
LTTMKNTSEL VSSEVYLLSA LAALQKVVET LPHFISPYLE GILSQVIHLE KITSEMGSAS
      1810       1820       1830       1840       1850       1860
QANIRLTSLK KTLATTLAPR VLLPAIKKTY KQIEKNWKNH MGPFMSILQE HIGVMKKEEL
      1870       1880       1890       1900       1910       1920
TSHQSQLTAF FLEALDFRAQ HSENDLEEVG KTENCIIDCL VAMVVKLSEV TFRPLFFKLF
      1930       1940       1950       1960       1970       1980
DWAKTEDAPK DRLLTFYNLA DCIAEKLKGL FTLFAGHLVK PFADTLNQVN ISKTDEAFFD
      1990       2000       2010       2020       2030       2040
SENDPEKCCL LLQFILNCLY KIFLFDTQHF ISKERAEALM MPLVDQLENR LGGEEKFQER
      2050       2060       2070       2080       2090       2100
VTKHLIPCIA QFSVAMADDS LWKPLNYQIL LKTRDSSPKV RFAALITVLA LAEKLKENYI
      2110       2120       2130       2140
VLLPESIPFL AELMEDECEE VEHQCQKTIQ QLETVLGEPL QSYF

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H583-1-Acetylation	MTSLAQ...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H583-1-Acetylation	MTSLAQ...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9H583-2-Acetylation	TSLAQQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H583-2-Acetylation	TSLAQQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9H583-2-Acetylation	TSLAQQ...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9H583-2-Acetylation	TSLAQQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9H583-1362-unknown	SGDSIE...	1362		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13313
Q9H583-1681-unknown	FGAENP...	1681		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6778

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WLIHRF	120	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000355538
...LIQSDS	1361	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13313
...LLCKNF	1680	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6778
...LQSYF	2144	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	1361	QSDS.\|.SGDS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	1680	CKNF.\|.FGAE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)