P09936: Ubiquitin carboxyl-terminal hydrolase isozyme L1

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase isozyme L1 - UCH-L1 - 3.4.19.12 {ECO:0000269\|PubMed:12408865, ECO:0000269\|PubMed:12705903, ECO:0000269\|PubMed:16475834, ECO:0000269\|PubMed:20439756, ECO:0000269\|PubMed:23359680, ECO:0000269\|PubMed:8639624, ECO:0000269\|PubMed:9774100} - Neuron cytoplasmic protein 9.5 - PGP 9.5 - PGP9.5 - Ubiquitin thioesterase L1
Gene names	UCHL1
Organism	Homo sapiens
Protease Family
Protease ID	C12.001
Chromosome location
UniProt ID	P09936

7 N-termini

7 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE
        70         80         90        100        110        120
NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE
       130        140        150        160        170        180
TEKMSPEDRA KCFEKNEAIQ AAHDAVAQEG QCRVDDKVNF HFILFNNVDG HLYELDGRMP
       190        200        210        220
FPVNHGASSE DTLLKDAAKV CREFTEREQG EVRFSAVALC KAA

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P09936-1-	MQLKPM...	1		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P09936-1-	MQLKPM...	1		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P09936-1-	MQLKPM...	1		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P09936-1-unknown	MQLKPM...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P09936-57-unknown	AQHENF...	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5521
P09936-92-unknown	TIGLIH...	92	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3551
P09936-141-unknown	AAHDAV...	141	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7267
P09936-141-unknown	AAHDAV...	141	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5522
P09936-180-unknown	PFPVNH...	180	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3552
P09936-185-unknown	HGASSE...	185	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7268
P09936-185-unknown	HGASSE...	185	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5523
P09936-185-unknown	HGASSE...	185	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3553

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LFPLTA	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5521
...PLTAQH	58	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426634
...GNSCGT	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3551
...NEAIQA	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7267
...NEAIQA	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5522
...LDGRMP	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3552
...PFPVNH	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7268
...PFPVNH	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5523
...PFPVNH	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3553
...AVALCK	220	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	56	PLTA.\|.AQHE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	91	SCGT.\|.TIGL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	140	AIQA.\|.AAHD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	140	AIQA.\|.AAHD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	179	GRMP.\|.PFPV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	184	PVNH.\|.HGAS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	184	PVNH.\|.HGAS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	184	PVNH.\|.HGAS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)