Q14320: Protein FAM50A

General Information

Protein names	- Protein FAM50A - Protein HXC-26 - Protein XAP-5
Gene names	FAM50A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14320

8 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAQYKGAASE AGRAMHLMKK REKQREQMEQ MKQRIAEENI MKSNIDKKFS AHYDAVEAEL
        70         80         90        100        110        120
KSSTVGLVTL NDMKAKQEAL VKEREKQLAK KEQSKELQMK LEKLREKERK KEAKRKISSL
       130        140        150        160        170        180
SFTLEEEEEG GEEEEEAAMY EEEMEREEIT TKKRKLGKNP DVDTSFLPDR DREEEENRLR
       190        200        210        220        230        240
EELRQEWEAK QEKIKSEEIE ITFSYWDGSG HRRTVKMRKG NTMQQFLQKA LEILRKDFSE
       250        260        270        280        290        300
LRSAGVEQLM YIKEDLIIPH HHSFYDFIVT KARGKSGPLF NFDVHDDVRL LSDATVEKDE
       310        320        330
SHAGKVVLRS WYEKNKHIFP ASRWEPYDPE KKWDKYTIR

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14320-2-unknown	MAQYKG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14320-2-Acetylation	AQYKGA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14320-2-Acetylation	AQYKGA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q14320-2-Acetylation	AQYKGA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q14320-2-Acetylation	AQYKGA...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q14320-41-unknown	MKSNID...	41		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000158526
Q14320-41-unknown	MKSNID...	41		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000471195
Q14320-50-	SAHYDA...	50			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14320-50-	SAHYDA...	50			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q14320-50-	SAHYDA...	50			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14320-50-	SAHYDA...	50			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14320-50-	SAHYDA...	50			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14320-50-	SAHYDA...	50			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14320-50-	SAHYDA...	50			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14320-62-	SSTVGL...	62			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14320-164-unknown	TSFLPD...	164		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12228
Q14320-281-unknown	NFDVHD...	281		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6396
Q14320-292-	SDATVE...	292			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NPDVDT	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12228
...SGPLFN	280	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6396
...VEKDES	300	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000158526
...VEKDES	300	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471195
...KYTIR	339	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	163	DVDT.\|.TSFL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	280	PLFN.\|.NFDV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)