Q14232: Translation initiation factor eIF-2B subunit alpha

General Information

Protein names	- Translation initiation factor eIF-2B subunit alpha - eIF-2B GDP-GTP exchange factor subunit alpha
Gene names	EIF2B1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14232

3 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDDKELIEYF KSQMKEDPDM ASAVAAIRTL LEFLKRDKGE TIQGLRANLT SAIETLCGVD
        70         80         90        100        110        120
SSVAVSSGGE LFLRFISLAS LEYSDYSKCK KIMIERGELF LRRISLSRNK IADLCHTFIK
       130        140        150        160        170        180
DGATILTHAY SRVVLRVLEA AVAAKKRFSV YVTESQPDLS GKKMAKALCH LNVPVTVVLD
       190        200        210        220        230        240
AAVGYIMEKA DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP
       250        260        270        280        290        300
LNQQDVPDKF KYKADTLKVA QTGQDLKEEH PWVDYTAPSL ITLLFTDLGV LTPSAVSDEL

IKLYL

Isoforms

- Isoform 2 of Translation initiation factor eIF-2B subunit alpha

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q14232-1-unknown	MDDKEL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q14232-14-unknown	MKEDPD...	14	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438060
Q14232-243-unknown	QQDVPD...	243	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7832
Q14232-243-unknown	QQDVPD...	243	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6395

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LFPLNQ	242	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7832
...LFPLNQ	242	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6395
...IKLYL	305	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	242	PLNQ.\|.QQDV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	242	PLNQ.\|.QQDV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)