P50502: Hsc70-interacting protein

General Information

Protein names	- Hsc70-interacting protein - Hip - Aging-associated protein 2 - Progesterone receptor-associated p48 protein - Protein FAM10A1 - Putative tumor suppressor ST13 - Renal carcinoma antigen NY-REN-33 - Suppression of tumorigenicity 13 protein
Gene names	ST13
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P50502

7 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDPRKVNELR AFVKMCKQDP SVLHTEEMRF LREWVESMGG KVPPATQKAK SEENTKEEKP
        70         80         90        100        110        120
DSKKVEEDLK ADEPSSEESD LEIDKEGVIE PDTDAPQEMG DENAEITEEM MDQANDKKVA
       130        140        150        160        170        180
AIEALNDGEL QKAIDLFTDA IKLNPRLAIL YAKRASVFVK LQKPNAAIRD CDRAIEINPD
       190        200        210        220        230        240
SAQPYKWRGK AHRLLGHWEE AAHDLALACK LDYDEDASAM LKEVQPRAQK IAEHRRKYER
       250        260        270        280        290        300
KREEREIKER IERVKKAREE HERAQREEEA RRQSGAQYGS FPGGFPGGMP GNFPGGMPGM
       310        320        330        340        350        360
GGGMPGMAGM PGLNEILSDP EVLAAMQDPE VMVAFQDVAQ NPANMSKYQS NPKVMNLISK

LSAKFGGQA

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P50502-1-unknown	MDPRKV...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P50502-38-unknown	MGGKVP...	38	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392067
P50502-53-unknown	ENTKEE...	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17687
P50502-93-unknown	TDAPQE...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11615
P50502-181-unknown	SAQPYK...	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11616
P50502-197-unknown	HWEEAA...	197	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5948
P50502-197-unknown	HWEEAA...	197	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7525
P50502-228-unknown	AQKIAE...	228	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31784

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KAKSEE	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17687
...VIEPDT	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11615
...EINPDS	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11616
...HRLLGH	196	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5948
...HRLLGH	196	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7525
...LGHWEE	199	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392067
...EVQPRA	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31784
...FGGQA	369	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	52	KSEE.\|.ENTK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	92	EPDT.\|.TDAP	inferred from experiment	unknown	MEROPS	Reiners JJ Jr	Caruso JA et al.:Proteolysis of HIP during apopt... (S01.010)	17013759,
GRAB_HUMAN	180	NPDS.\|.SAQP	inferred from experiment	unknown	MEROPS	Craik CS	Hostetter DR et al.:Hip is a pro-survival substrate... (S01.010)	17620340,
CATL1_HUMAN	196	LLGH.\|.HWEE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	196	LLGH.\|.HWEE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
THRB_HUMAN	227	QPRA.\|.AQKI	inferred from experiment	unknown	MEROPS	Ladjimi MM	Velten M et al.:Domain structure of the HSC70 c... (S01.217)	11687574,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)