P22061: Protein-L-isoaspartate(D-aspartate) O-methyltransferase

General Information

Protein names	- Protein-L-isoaspartate(D-aspartate) O-methyltransferase - PIMT - 2.1.1.77 - L-isoaspartyl protein carboxyl methyltransferase - Protein L-isoaspartyl/D-aspartyl methyltransferase - Protein-beta-aspartate methyltransferase
Gene names	PCMT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P22061

12 N-termini

8 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAWKSGGASH SELIHNLRKN GIIKTDKVFE VMLATDRSHY AKCNPYMDSP QSIGFQATIS
        70         80         90        100        110        120
APHMHAYALE LLFDQLHEGA KALDVGSGSG ILTACFARMV GCTGKVIGID HIKELVDDSV
       130        140        150        160        170        180
NNVRKDDPTL LSSGRVQLVV GDGRMGYAEE APYDAIHVGA AAPVVPQALI DQLKPGGRLI
       190        200        210        220
LPVGPAGGNQ MLEQYDKLQD GSIKMKPLMG VIYVPLTDKE KQWSRWK

Isoforms

- Isoform 2 of Protein-L-isoaspartate(D-aspartate) O-methyltransferase

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

12 N-termini - 8 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P22061-2-unknown	MAWKSG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P22061-1-unknown	MAWKSG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85243
P22061-2-Acetylation	AWKSGG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P22061-2-Acetylation	AWKSGG...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P22061-2-Acetylation	AWKSGG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111143
P22061-32-unknown	MLATDR...	32		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000418881
P22061-32-unknown	MLATDR...	32		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132281
P22061-149-unknown	EEAPYD...	149		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7358
P22061-149-unknown	EEAPYD...	149		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144696
P22061-160-unknown	AAAPVV...	160		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176113
P22061-160-	AAAPVV...	160			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P22061-168-unknown	ALIDQL...	168		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17484
P22061-168-unknown	ALIDQL...	168		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145444
P22061-169-unknown	LIDQLK...	169		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17486
P22061-169-unknown	LIDQLK...	169		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145494
P22061-194-unknown	QYDKLQ...	194		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5662
P22061-194-unknown	QYDKLQ...	194		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146376
P22061-210-unknown	GVIYVP...	210		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5664
P22061-210-unknown	GVIYVP...	210		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3681
P22061-211-unknown	VIYVPL...	211		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3683

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VRKDDP	127	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000418881
...VRKDDP	127	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113499
...RMGYAE	148	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7358
...RMGYAE	148	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127964
...PVVPQA	167	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17484
...PVVPQA	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128738
...VVPQAL	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17486
...VVPQAL	168	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128790
...NQMLEQ	193	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5662
...NQMLEQ	193	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129680
...MKPLMG	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5664
...MKPLMG	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3681
...MKPLMG	209	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130274
...KPLMGV	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3683
...KPLMGV	210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130338
...WSRWK	227	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	148	GYAE.\|.EEAP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	167	VPQA.\|.ALID	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	168	PQAL.\|.LIDQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	193	MLEQ.\|.QYDK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	209	PLMG.\|.GVIY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	209	PLMG.\|.GVIY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	210	LMGV.\|.VIYV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)