P52272: Heterogeneous nuclear ribonucleoprotein M

General Information

Protein names	- Heterogeneous nuclear ribonucleoprotein M - hnRNP M
Gene names	HNRNPM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P52272

41 N-termini

14 C-termini

18 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAGVEAAAE VAATEIKMEE ESGAPGVPSG NGAPGPKGEG ERPAQNEKRK EKNIKRGGNR
        70         80         90        100        110        120
FEPYANPTKR YRAFITNIPF DVKWQSLKDL VKEKVGEVTY VELLMDAEGK SRGCAVVEFK
       130        140        150        160        170        180
MEESMKKAAE VLNKHSLSGR PLKVKEDPDG EHARRAMQKV MATTGGMGMG PGGPGMITIP
       190        200        210        220        230        240
PSILNNPNIP NEIIHALQAG RLGSTVFVAN LDYKVGWKKL KEVFSMAGVV VRADILEDKD
       250        260        270        280        290        300
GKSRGIGTVT FEQSIEAVQA ISMFNGQLLF DRPMHVKMDE RALPKGDFFP PERPQQLPHG
       310        320        330        340        350        360
LGGIGMGLGP GGQPIDANHL NKGIGMGNIG PAGMGMEGIG FGINKMGGME GPFGGGMENM
       370        380        390        400        410        420
GRFGSGMNMG RINEILSNAL KRGEIIAKQG GGGGGGSVPG IERMGPGIDR LGGAGMERMG
       430        440        450        460        470        480
AGLGHGMDRV GSEIERMGLV MDRMGSVERM GSGIERMGPL GLDHMASSIE RMGQTMERIG
       490        500        510        520        530        540
SGVERMGAGM GFGLERMAAP IDRVGQTIER MGSGVERMGP AIERMGLSME RMVPAGMGAG
       550        560        570        580        590        600
LERMGPVMDR MATGLERMGA NNLERMGLER MGANSLERMG LERMGANSLE RMGPAMGPAL
       610        620        630        640        650        660
GAGIERMGLA MGGGGGASFD RAIEMERGNF GGSFAGSFGG AGGHAPGVAR KACQIFVRNL
       670        680        690        700        710        720
PFDFTWKMLK DKFNECGHVL YADIKMENGK SKGCGVVKFE SPEVAERACR MMNGMKLSGR
       730
EIDVRIDRNA

Isoforms

- Isoform 2 of Heterogeneous nuclear ribonucleoprotein M

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

41 N-termini - 14 C-termini - 18 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P52272-1-unknown	MAAGVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77180
P52272-2-unknown	MAAGVE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52272-2-unknown	MAAGVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170463
P52272-2-Acetylation	AAGVEA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52272-2-Acetylation	AAGVEA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P52272-2-Acetylation	AAGVEA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110784
P52272-2-	AAGVEA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52272-7-unknown	AAAEVA...	7		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170459
P52272-7-	AAAEVA...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52272-7-	AAAEVA...	7			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52272-7-	AAAEVA...	7			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P52272-23-	GAPGVP...	23			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52272-23-unknown	GAPGVP...	23		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177576
P52272-32-unknown	GAPGPK...	32		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170465
P52272-32-	GAPGPK...	32			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52272-58-unknown	GNRFEP...	58		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P52272-58-unknown	GNRFEP...	58		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196273
P52272-235-unknown	ILEDKD...	235		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11650
P52272-235-unknown	ILEDKD...	235		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146467
P52272-301-unknown	LGGIGM...	301		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3827
P52272-301-unknown	LGGIGM...	301		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148909
P52272-303-	GIGMGL...	303			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P52272-303-	GIGMGL...	303			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52272-303-	GIGMGL...	303			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52272-303-unknown	GIGMGL...	303		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166710
P52272-306-unknown	MGLGPG...	306		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5982
P52272-306-unknown	MGLGPG...	306		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3829
P52272-306-unknown	MGLGPG...	306		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149043
P52272-307-unknown	GLGPGG...	307		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5984
P52272-307-unknown	GLGPGG...	307		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149071
P52272-308-unknown	LGPGGQ...	308		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3831
P52272-308-unknown	LGPGGQ...	308		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149105
P52272-392-unknown	GGGGGS...	392		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170461
P52272-392-	GGGGGS...	392			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52272-423-unknown	LGHGMD...	423		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3833
P52272-423-unknown	LGHGMD...	423		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151726
P52272-532-unknown	MVPAGM...	532		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166712
P52272-532-	MVPAGM...	532			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P52272-532-	MVPAGM...	532			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52272-532-	MVPAGM...	532			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P52272-532-	MVPAGM...	532			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52272-608-	GLAMGG...	608			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P52272-608-	GLAMGG...	608			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P52272-608-	GLAMGG...	608			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52272-608-unknown	GLAMGG...	608			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P52272-608-unknown	GLAMGG...	608		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159744
P52272-610-unknown	AMGGGG...	610		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169455
P52272-610-	AMGGGG...	610			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P52272-610-	AMGGGG...	610			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52272-611-unknown	MGGGGG...	611		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5986
P52272-611-unknown	MGGGGG...	611		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3835
P52272-611-unknown	MGGGGG...	611		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154238
P52272-612-	GGGGGA...	612			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52272-612-unknown	GGGGGA...	612		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177578
P52272-621-unknown	RAIEME...	621		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11652
P52272-621-unknown	RAIEME...	621		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154357
P52272-632-unknown	GSFAGS...	632		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3837
P52272-632-unknown	GSFAGS...	632		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154510
P52272-633-unknown	SFAGSF...	633			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P52272-633-unknown	SFAGSF...	633		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159746
P52272-633-	SFAGSF...	633			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P52272-633-	SFAGSF...	633			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P52272-633-	SFAGSF...	633			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52272-633-	SFAGSF...	633			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52272-635-unknown	AGSFGG...	635		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166707
P52272-635-	AGSFGG...	635			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P52272-635-	AGSFGG...	635			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52272-636-unknown	GSFGGA...	636		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7539
P52272-636-unknown	GSFGGA...	636		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3839
P52272-636-unknown	GSFGGA...	636		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154544
P52272-637-unknown	SFGGAG...	637		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3841
P52272-637-unknown	SFGGAG...	637		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154553
P52272-637-	SFGGAG...	637			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52272-639-unknown	GGAGGH...	639		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5988
P52272-639-unknown	GGAGGH...	639		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154587
P52272-640-unknown	GAGGHA...	640		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3843
P52272-640-unknown	GAGGHA...	640		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5990
P52272-640-unknown	GAGGHA...	640		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7541
P52272-640-unknown	GAGGHA...	640		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154591

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VVRADI	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11650
...VVRADI	234	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129774
...QLPHGL	300	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3827
...QLPHGL	300	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132289
...LGGIGM	305	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5982
...LGGIGM	305	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3829
...LGGIGM	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132427
...GGIGMG	306	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5984
...GGIGMG	306	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132455
...GIGMGL	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3831
...GIGMGL	307	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132490
...RMGAGL	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3833
...RMGAGL	422	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135130
...RMGLAM	610	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5986
...RMGLAM	610	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3835
...RMGLAM	610	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137659
...GASFDR	620	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11652
...GASFDR	620	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137778
...RGNFGG	631	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3837
...RGNFGG	631	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137932
...GGSFAG	635	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7539
...GGSFAG	635	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3839
...GGSFAG	635	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137966
...GSFAGS	636	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3841
...GSFAGS	636	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137976
...FAGSFG	638	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5988
...FAGSFG	638	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138011
...AGSFGG	639	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3843
...AGSFGG	639	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5990
...AGSFGG	639	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7541
...AGSFGG	639	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138015
...IDRNA	730	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IDRNA	730	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72798

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	234	RADI.\|.ILED	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATB_HUMAN	300	PHGL.\|.LGGI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	305	GIGM.\|.MGLG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	305	GIGM.\|.MGLG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	306	IGMG.\|.GLGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	307	GMGL.\|.LGPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	422	GAGL.\|.LGHG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	610	GLAM.\|.MGGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	610	GLAM.\|.MGGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	620	SFDR.\|.RAIE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATB_HUMAN	631	NFGG.\|.GSFA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	635	SFAG.\|.GSFG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	635	SFAG.\|.GSFG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	636	FAGS.\|.SFGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	638	GSFG.\|.GGAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	639	SFGG.\|.GAGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	639	SFGG.\|.GAGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	639	SFGG.\|.GAGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)