P05387: 60S acidic ribosomal protein P2

General Information

Protein names	- 60S acidic ribosomal protein P2 - Large ribosomal subunit protein P2 {ECO:0000303\|PubMed:24524803} - Renal carcinoma antigen NY-REN-44
Gene names	RPLP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05387

22 N-termini

10 C-termini

14 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MRYVASYLLA ALGGNSSPSA KDIKKILDSV GIEADDDRLN KVISELNGKN IEDVIAQGIG
70 80 90 100 110
KLASVPAGGA VAVSAAPGSA APAAGSAPAA AEEKKDEKKE ESEESDDDMG FGLFD

Isoforms

Sequence View

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

22 N-termini - 10 C-termini - 14 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P05387-1-Acetylation	MRYVAS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P05387-5-	ASYLLA...	5			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P05387-8-	LLAALG...	8			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05387-9-	LAALGG...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05387-10-	AALGGN...	10			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P05387-10-	AALGGN...	10			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05387-11-unknown	ALGGNS...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5401
P05387-11-unknown	ALGGNS...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7202
P05387-11-unknown	ALGGNS...	11			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P05387-11-	ALGGNS...	11			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P05387-11-	ALGGNS...	11			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P05387-11-	ALGGNS...	11			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05387-29-	SVGIEA...	29			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05387-29-unknown	SVGIEA...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5402
P05387-29-unknown	SVGIEA...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7203
P05387-29-unknown	SVGIEA...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3485
P05387-32-unknown	IEADDD...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5403
P05387-64-	SVPAGG...	64			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P05387-64-	SVPAGG...	64			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05387-64-	SVPAGG...	64			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P05387-72-	AVSAAP...	72			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05387-73-unknown	VSAAPG...	73		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3486
P05387-74-	SAAPGS...	74			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05387-74-	SAAPGS...	74			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P05387-74-	SAAPGS...	74			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P05387-75-	AAPGSA...	75			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P05387-75-	AAPGSA...	75			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05387-75-	AAPGSA...	75			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P05387-75-	AAPGSA...	75			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P05387-75-unknown	AAPGSA...	75		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5404
P05387-75-unknown	AAPGSA...	75		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3487
P05387-76-unknown	APGSAA...	76		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3488
P05387-79-	SAAPAA...	79			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05387-79-unknown	SAAPAA...	79		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5405
P05387-79-unknown	SAAPAA...	79		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3489
P05387-80-	AAPAAG...	80			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05387-85-unknown	GSAPAA...	85		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3490
P05387-86-unknown	SAPAAA...	86		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7204

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SYLLAA	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5401
...SYLLAA	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7202
...KKILDS	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5402
...KKILDS	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7203
...KKILDS	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3485
...LDSVGI	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5403
...GGAVAV	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3486
...AVAVSA	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5404
...AVAVSA	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3487
...VAVSAA	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3488
...SAAPGS	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5405
...SAAPGS	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3489
...AAPAAG	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3490
...APAAGS	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7204
...FGLFD	115	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	10	LLAA.\|.ALGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	10	LLAA.\|.ALGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	28	ILDS.\|.SVGI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	28	ILDS.\|.SVGI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	28	ILDS.\|.SVGI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	31	SVGI.\|.IEAD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	72	AVAV.\|.VSAA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	74	AVSA.\|.AAPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	74	AVSA.\|.AAPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	75	VSAA.\|.APGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	78	APGS.\|.SAAP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	78	APGS.\|.SAAP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	84	PAAG.\|.GSAP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	85	AAGS.\|.SAPA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)