Q99436: Proteasome subunit beta type-7

General Information

Protein names	- Proteasome subunit beta type-7 - 3.4.25.1 {ECO:0000269\|PubMed:27176742} - Macropain chain Z - Multicatalytic endopeptidase complex chain Z - Proteasome subunit Z
Gene names	PSMB7
Organism	Homo sapiens
Protease Family	T01.011
Protease ID	T01.011
Chromosome location
UniProt ID	Q99436

7 N-termini

3 C-termini

2 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MAAVSVYAPP VGGFSFDNCR RNAVLEADFA KRGYKLPKVR KTGTTIAGVV YKDGIVLGAD
        70         80         90        100        110        120
TRATEGMVVA DKNCSKIHFI SPNIYCCGAG TAADTDMTTQ LISSNLELHS LSTGRLPRVV
       130        140        150        160        170        180
TANRMLKQML FRYQGYIGAA LVLGGVDVTG PHLYSIYPHG STDKLPYVTM GSGSLAAMAV
       190        200        210        220        230        240
FEDKFRPDME EEEAKNLVSE AIAAGIFNDL GSGSNIDLCV ISKNKLDFLR PYTVPNKKGT
       250        260        270
RLGRYRCEKG TTAVLTEKIT PLEIEVLEET VQTMDTS

Isoforms

- Isoform 2 of Proteasome subunit beta type-7

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 2 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99436-2-acetylation	AAVSVY...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q99436-44-	TTIAGV...	44			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q99436-44-	TTIAGV...	44			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99436-44-	TTIAGV...	44			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q99436-44-	TTIAGV...	44			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q99436-44-	TTIAGV...	44			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q99436-44-	TTIAGV...	44			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q99436-44-unknown	TTIAGV...	44		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99436-54-	GIVLGA...	54			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99436-54-	GIVLGA...	54			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q99436-88-	GAGTAA...	88			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99436-141-unknown	LVLGGV...	141		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4205
Q99436-144-unknown	GGVDVT...	144		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6702

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YIGAAL	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4205
...AALVLG	143	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6702
...TMDTS	277	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	140	GAAL.\|.LVLG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	143	LVLG.\|.GGVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
JAK1_HUMAN	374	ITHI.\|.IVIK	inferred from experiment	unknown	MEROPS	Schild H	Dick TP et al.:Contribution of proteasomal bet... (T01.011)	9748229,