Q6DKJ4: Nucleoredoxin

General Information

Protein names	- Nucleoredoxin - 1.8.1.8
Gene names	NXN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6DKJ4

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Nucleoredoxin - Isoform 3 of Nucleoredoxin

Sequence View

        10         20         30         40         50         60
MSGFLEELLG EKLVTGGGEE VDVHSLGARG ISLLGLYFGC SLSAPCAQLS ASLAAFYGRL
        70         80         90        100        110        120
RGDAAAGPGP GAGAGAAAEP EPRRRLEIVF VSSDQDQRQW QDFVRDMPWL ALPYKEKHRK
       130        140        150        160        170        180
LKLWNKYRIS NIPSLIFLDA TTGKVVCRNG LLVIRDDPEG LEFPWGPKPF REVIAGPLLR
       190        200        210        220        230        240
NNGQSLESSS LEGSHVGVYF SAHWCPPCRS LTRVLVESYR KIKEAGQNFE IIFVSADRSE
       250        260        270        280        290        300
ESFKQYFSEM PWLAVPYTDE ARRSRLNRLY GIQGIPTLIM LDPQGEVITR QGRVEVLNDE
       310        320        330        340        350        360
DCREFPWHPK PVLELSDSNA AQLNEGPCLV LFVDSEDDGE SEAAKQLIQP IAEKIIAKYK
       370        380        390        400        410        420
AKEEEAPLLF FVAGEDDMTD SLRDYTNLPE AAPLLTILDM SARAKYVMDV EEITPAIVEA
       430
FVNDFLAEKL KPEPI         10         20         30         40         50         60
MSGFLEELLG EKLVTGGGEE VDVHSLGARG ISLLGLYFGC SLSAPCAQLS ASLAAFYGRL
        70         80         90        100        110        120
RGDAAAGPGP GAGAGAAAEP EPRRRLEIVF VSSDQDQRQW QDFVRDMPWL ALPYKEKHRK
       130        140        150        160        170        180
LKLWNKYRIS NIPSLIFLDA TTGKVVCRNG LLVIRDDPEG LEFPWGPKPF REVIAGPLLR
       190        200        210        220        230        240
NNGQSLESSS LEGSHVGVYF SAHWCPPCRS LTRVLVESYR KIKEAGQNFE IIFVSADRSE
       250        260        270        280        290        300
ESFKQYFSEM PWLAVPYTDE ARRSRLNRLY GIQGIPTLIM LDPQGEVITR QGRVEVLNDE
       310        320        330        340        350        360
DCREFPWHPK PVLELSDSNA AQLNEGPCLV LFVDSEDDGE SEAAKQLIQP IAEKIIAKYK
       370        380        390        400        410        420
AKEEEAPLLF FVAGEDDMTD SLRDYTNLPE AAPLLTILDM SARAKYVMDV EEITPAIVEA
       430
FVNDFLAEKL KPEPI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q6DKJ4-2-unknown	MSGFLE...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q6DKJ4-2-Acetylation	SGFLEE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q6DKJ4-63-unknown	DAAAGP...	63		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6538
Q6DKJ4-250-unknown	MPWLAV...	250		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446446
Q6DKJ4-250-unknown	MPWLAV...	250		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445087
Q6DKJ4-250-unknown	MPWLAV...	250		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198451
Q6DKJ4-250-unknown	MPWLAV...	250		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198450

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GRLRGD	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6538
...KPEPI	435	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KPEPI	435	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79210

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	62	LRGD.\|.DAAA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)